Innovative approaches towards an economic fusion reactor     

Houyang Guo  Francis Y C Thio  Michl W Binderbauer  Richard J Buttery  Thomas R Jarboe  Rajesh Maingi  John S Sarff  Peter C Stangeby  Derek A Sutherland  Mickey R Wade  Michael C Zarnstorff 《国家科学评论(英文版)》2020,7(2):245

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Role of Oxidative Stress in Various Stages of Psoriasis     

Kadam DP  Suryakar AN  Ankush RD  Kadam CY  Deshpande KH 《Indian journal of clinical biochemistry : IJCB》2010,25(4):388-392

Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently, it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects) and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects. As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and decreased antioxidant potential in psoriasis.  相似文献   

Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years     

Samantha Plate  Lisa Yankowitz  Leslie Resorla  Meghan R. Swanson  Shoba Sreenath Meera  Annette Estes  Natasha Marrus  Meredith Cola  Victoria Petrulla  Aubrey Faggen  Juhi Pandey  Sarah Paterson  John R. Pruett Jr.  Heather Hazlett  Stephen Dager  Tanya St. John  Kelly Botteron  Lonnie Zwaigenbaum  Joseph Piven  Robert T. Schultz  Julia Parish-Morris  IBIS Network 《Child development》2022,93(2):468-483

Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR-ASD infants produced fewer vocalizations than HR-Neg infants. From 6 to 24 months, HR-Neg infants demonstrated steeper vocalization growth compared to HR-ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.  相似文献   

Diurnal variation in serum glucose,pyruvate, lactate and lactate dehydrogenase levels under different environmental temperatures     

S. K. Bansal  H. N. Pandey  A. Bansal  L. D. Joshi 《Indian journal of clinical biochemistry : IJCB》1992,7(2):179-184

Circadian rhythm of serum glucose, pyruvate, lactate and lactate dehydrogenase (LDH) was studied in normal healthy young volunteers at the onset (I Group, 7 cases) and peak (II Group, 8 cases) of winters in India with highly varied temperature. There was a significant difference, in the circadian rhythm of glucose, pyruvate and lactate dehydrogenase (LDH) of the two groups. A clockwise shift was observed in acrophase except in serum lactate, which is related to the energy demand in association with time qualified changes in diurnal activity of the individuals and change in photoperiod.  相似文献   

Lipid peroxide levels and antioxidant status in alcoholic liver disease     

Seema Gupta  Rajesh Pandey  Ranjan Katyal  H. K. Aggarwal  R. P. Aggarwal  S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2005,20(1):67-71

The present study was conducted to evaluate some of the components of antioxidant defense system and oxidative damage in 20 male patients of alcoholic liver disease (ALD). The results were compared with 20 healthy male smokers and 20 healthy male non-smokers volunteers. Patients were subjected to detailed clinical examination and laboratory investigations. Blood samples were collected for estimating reduced glutathione (GSH), total thiols (T-SH) malondialdehyde (MDA), transaminases (AST, ALT), glutathione-S-transferease (GST) and gammaglutamyl transferase (GGT). Serum aspartate amino transferase (AST)/alanine amino transferase (ALT) ratio was significantly (p<0.01) reduced in ALD patients as compared to the controls. However, the core of utility of MDA and GST was found to be significantly (p<0.01) increased in ALD patients compared to controls. There was a significant negative correlation of MDA with both GSH and TSH. Plasma GGT levels were significantly (p<0.01) increased in alcoholics and the enzyme showed a significant positive correlation with MDA. These results give enough evidence of increased oxidative stress and compromised antioxidant defense system in patients with ALD.  相似文献   

Some biochemical markers in various neoplasms: A multivariate analysis     

Bhawana Nigam  S. P. Joshi  Seema Nagar  Rajesh Chavan  D. Pendharkar 《Indian journal of clinical biochemistry : IJCB》1996,11(2):124-128

The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders.  相似文献   

Amplitude-modulated sinusoidal microchannels for observing adaptability in C. elegans locomotion     

Parashar A  Lycke R  Carr JA  Pandey S 《Biomicrofluidics》2011,5(2):24112

In this paper, we present a movement-based assay to observe adaptability in Caenorhabditis elegans locomotion behavior. The assay comprises a series of sinusoidal microchannels with a fixed wavelength and modulating (increasing or decreasing) amplitude. The channel width is comparable to the body diameter of the organism. Worms are allowed to enter the channel from the input port and migrate toward the output port. Within channel sections that closely match the worm's natural undulations, the worm movement is relatively quick and steady. As the channel amplitude increases or decreases along the device, the worm faces difficulty in generating the propulsive thrust, begins to slow down and eventually fails to move forward. A set of locomotion parameters (i.e., average forward velocity, number and duration of stops, range of contact angle, and cut-off region) is defined for worm locomotion in modulated sinusoidal channels and extracted from the recorded videos. The device is tested on wild-type C. elegans (N2) and two mutants (lev-8 and unc-38). We anticipate this passive, movement-based assay can be used to screen nematodes showing difference in locomotion phenotype.  相似文献   

Increased Homocysteine Level in Indian Sickle Cell Anemia Patients     

S. Pandey  H. R. Pandey  R. M. Mishra  Sw. Pandey  R. Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(1):103-104

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雾中漫步(英文)     

Rajesh KenoiJack 《海外英语》2008,(2):46-47

Jack现在南京任教,对这片土地的热爱促使他千里迢迢从印度来到中国。他很乐意与读者朋友们交流,他的E-mail地址是:jackkanoi@hotmail.com  相似文献   

风之影     

Rajesh Kanoi 《海外英语》2007,(12):1

The air is a sea of gases, And the wind is restless waves;When it wants it can sustain life,And take it when it craves. A flame can live with ardor,Its posture straight and strong,When the wind is quiet and gentle,For it becomes a loving mate. And, then, when fancy strikes.It can blow a strong willed gust.That will extinguish a struggling flame,And turn to less than dust. The wind is air at peace,In love, it is a breeze;Disturbed and angry it becomes a storm,That tears down mighty trees.  相似文献