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Óscar Jerez Yàñez Fernanda Corvalán Canessa Lesslie González Rojas Armin Ramos Torres 《International Journal for Academic Development》2019,24(2):204-208
ABSTRACTWe propose a ‘1-to-1’ accompaniment and teaching development model emerging from the analysis and reflection of professional experience at a Teaching and Learning Center in a Chilean university. We highlight the relevance of the bond between professor and adviser and the establishment of a horizontal relationship, where both work collaboratively on the achievement of common objectives. This means breaking away from the classic view of the counseling process, where aspects of discipline and context are not necessarily considered. Despite size scalability issues, this model is flexible in its applicability and is adaptable to different university contexts. The implementation of this model is still under development, particularly in its evaluation phase. 相似文献
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Dielectrophoresis (DEP) of biomolecules has large potential to serve as a novel selectivity parameter for bioanalytical methods such as (pre)concentration, fractionation, and separation. However, in contrast to well-characterized biological cells and (nano)particles, the mechanism of protein DEP is poorly understood, limiting bioanalytical applications for proteins. Here, we demonstrate a detailed investigation of factors influencing DEP of diagnostically relevant immunoglobulin G (IgG) molecules using insulator-based DEP (iDEP) under DC conditions. We found that the pH range in which concentration of IgG due to streaming iDEP occurs without aggregate formation matches the pH range suitable for immunoreactions. Numerical simulations of the electrokinetic factors pertaining to DEP streaming in this range further suggested that the protein charge and electroosmotic flow significantly influence iDEP streaming. These predictions are in accordance with the experimentally observed pH-dependent iDEP streaming profiles as well as the determined IgG molecular properties. Moreover, we observed a transition in the streaming behavior caused by a change from positive to negative DEP induced through micelle formation for the first time experimentally, which is in excellent qualitative agreement with numerical simulations. Our study thus relates molecular immunoglobulin properties to observed iDEP, which will be useful for the future development of protein (pre)concentration or separation methods based on DEP. 相似文献
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Fernanda Ribeiro 《Archival Science》1987,1(3):295-310
The dominant paradigm in Archival Science, thehistorical-technicist paradigm, has its origins with the French Revolution and raised from the social, economic, political, ideological and cultural
changes that occur during the 19th and 20th centuries. During this last one and due specially to the technological revolution
Archival Science reinforced its technical component and became autonomous in face of History, but the consolidation of the
model, based on a custodial, technicist and documentalist perspective, is associated to a knowledge essentially empirical.
By effect of the new conditions generated by Information Society, the dominant paradigm entered into a crisis and developed
inside itself the factors which, unavoidably, will produce the paradigm shift. The new paradigm — thescientific-informational paradigm — conceives Archival Science as an applied discipline into the scope of Information Science and defines unequivocally
its object of study — the archive, understood as aninformation system — and its scientific method of research. The method tends to find consolidation through quadripolar research dynamics, which
is operated and continuously repeated within the field of knowledge itself, which implies a permanent interaction on four
poles — epistemological, theoretical, technical and morphological. 相似文献
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Archival science and changes in the paradigm 总被引：1，自引：0，他引：1
Fernanda Ribeiro 《Archival Science》2001,1(3):295-310
The dominant paradigm in Archival Science, thehistorical-technicist paradigm, has its origins with the French Revolution and raised from the social, economic, political, ideological and cultural
changes that occur during the 19th and 20th centuries. During this last one and due specially to the technological revolution
Archival Science reinforced its technical component and became autonomous in face of History, but the consolidation of the
model, based on a custodial, technicist and documentalist perspective, is associated to a knowledge essentially empirical.
By effect of the new conditions generated by Information Society, the dominant paradigm entered into a crisis and developed
inside itself the factors which, unavoidably, will produce the paradigm shift. The new paradigm — thescientific-informational paradigm — conceives Archival Science as an applied discipline into the scope of Information Science and defines unequivocally
its object of study — the archive, understood as aninformation system — and its scientific method of research. The method tends to find consolidation through quadripolar research dynamics, which
is operated and continuously repeated within the field of knowledge itself, which implies a permanent interaction on four
poles — epistemological, theoretical, technical and morphological. 相似文献
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Fernanda Rafaela JARDIM Fhelipe Jolner Souza de ALMEIDA Matheus Dargesso LUCKACHAKI Marcos Roberto de OLIVEIRA 《Journal of Zhejiang University. Science. B》2020,21(4):263-279
有机硫化物萝卜硫烷(SFN)是一种有效的细胞保护剂,在体外和体内实验模型中均可促进抗氧化、抗炎、抗糖化和抗菌作用。因为氧化磷酸化系统的存在,所以线粒体是三磷酸腺苷(ATP)的主要产生部位。同时,线粒体也是具核人体细胞中产生活性氧的主要场所。线粒体损伤在多种人类疾病中起着重要作用,包括神经退行性病变和代谢异常。本文描述和讨论了SFN调节哺乳动物细胞中线粒体功能和动力学的作用和机理,以及其对肿瘤细胞中线粒体促凋亡途径的促进作用。SFN对线粒体的调节作用使得它在一定程度上被认为是一种细胞保护剂。本文还指出了几个需要通过进一步实验解决的问题,即未来的可能研究方向,这可能会对该领域的研究人员具有指导作用。 相似文献
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Cultural Studies of Science Education - Although in-depth educational reviews can be carried out building on curricular theories, the appropriation of this knowledge by science education... 相似文献
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Paulo Lima Junior Fernanda Ostermann Flavia Rezende 《Cultural Studies of Science Education》2014,9(3):591-597
In the first three sections of this paper we comment on some of the ideas developed in the forum papers, pointing out possible misunderstandings and constructing new explanations that clarify arguments we made in the original article. In the last section we expand the discussion raised in the original paper, elaborating on the limits of the use of Marxist approaches to sociocultural studies of science education. Following insights suggested by Loxley et al. (Cult Stud Sci Edu. doi:10.1007/s11422-013-9554-z, 2013) and detailed by Zuss (Cult Stud Sci Edu, 2014) on the commodification of knowledge, we sketch an analysis of how knowledge is transformed into capital to understand why contemporary scholars are likely to be engaged in a relation of production that resembles capitalist exploitation. 相似文献
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Aileen Hale Jennifer Snow-Gerono Fernanda Morales 《Teaching and Teacher Education》2008,24(6):1413-1425
This article presents a study of the effects of creating a bridge between the narrative and ethnographic methods and writing processes as a means to more effectively educate teachers of culturally diverse learners. Ten teacher participants from a Masters of Education (M.Ed.) degree program in Bilingual Education at a university in the northwestern United States took a sequence of courses in which instructor-researchers taught them narrative and ethnographic pedagogy, theory, and methodology. Through qualitative methods, instructor-researchers analyzed teacher participants’ personal narratives and ethnographic case studies for generative themes. In discovering the commonalities of themes between these two methods of inquiry, the research reveals the value and transformative nature of building a bridge between narrative and ethnographic methods. The following overlapping generative themes were voiced by teacher participants: (1) awareness of self and others; (2) consciousness of educational issues and their implications; (3) transformative action and advocacy. These themes are substantiated with related literature and further elucidated upon in the paper. 相似文献