Study of Common Genetic Variant S447X in Lipoprotein Lipase and Its Association with Lipids and Lipoproteins in Type 2 Diabetic Patients     

A. A. Momin  M. P. Bankar  G. M. Bhoite 《Indian journal of clinical biochemistry : IJCB》2016,31(3):286-293

Elevated plasma triglyceride and non-esterified fatty acid concentrations may cause insulin resistance and type 2 diabetes mellitus. Lipoprotein lipase (LPL) is a rate-determining enzyme in lipid metabolism. A variant in the LPL gene has been identified which alters the penultimate amino acid Serine at 447 to a stop codon (S447X), and results in a truncated LPL molecule lacking the C-terminal dipeptide Ser–Gly. The present study was designed to evaluate the frequency of S447X variant in the LPL gene and its effect on the lipid and lipoprotein levels in type 2 diabetic subjects. The genotype frequency distributions of type 2 diabetes patients and controls were in Hardy–Weinberg equilibrium. Comparison of the genotype and allelic frequencies of S447X in subjects with type 2 diabetics compared to controls demonstrated no significant difference. In subjects with type 2 diabetics having hypertriglyceridemia (TG ≥ 150 mg/dl) compared to diabetics with TG level <150 mg/dl, significant difference in genotype frequency was found among these groups, while allelic frequency of X was significantly differed. Logistic regression analysis showed the negative association of LPL S447X variant with TG and VLDL cholesterol, while no association with total cholesterol, HDL cholesterol and LDL cholesterol was found. The lipid levels except for HDL cholesterol were found to be significantly lower in carriers for S447X than wild type in diabetes group. The decreased level of TG and TG rich lipoprotein in subjects with SNP S447X in LPL, predicts anti-atherogenic activity of carriers for S447X variant in general population as well as type 2 diabetic patients.  相似文献   

A cost comparison of manual and automated circulation systems in university libraries: The case of the Ibadan University library     

G. A. Alabi 《Information processing & management》1985,21(6):525-533

This paper presents the results of a comparative cost study of the manual circulation system and experimental automated system in a university library in Nigeria. Two sets of data were collected: one on the existing manual circulation system and the other on the experimental automated system on an Apple II microcomputer. Eight different circulation activities were identified for evaluation for which the direct labor cost of circulating a book on each system was calculated. The experimental automated system was found to be less labor intensive than the manual system, although overall unit cost of book circulation on the automated system was higher than on the manual system ($0.59 and $0.49, respectively). Factors attributed to the higher unit cost on the automated system were the cost of equipment and the low circulation figure. However, the automated system was found to be more effective in providing up-to-date and accurate data required for the monitoring of the library stock.  相似文献   

Hypernetworks as tools for modelling multiport systems     

M. Gattinger  G. Wenzel 《Journal of The Franklin Institute》1984,317(1):1-6

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Study on arsenic level in public water supply of Delhi using hydride generator accessory coupled with atomic absorption spectrophotometer   总被引：1，自引：0，他引：1  

Sanjeev Lalwani  T. D. Dogra  D. N. Bhardwaj  R. K. Sharma  O. P. Murty 《Indian journal of clinical biochemistry : IJCB》2006,21(1):70-76

Exposure to arsenic has been associated with several health hazards. Worldwide the main reason for chronic human intoxication with arsenic is intake of contaminated drinking water. Air acetylene type of atomic absorption spectrophotometer in combination with hydride generator accessory was used to analyze arsenic level in 25 water samples collected from 25 booster pumping stations and 313 water samples collected from tap water supply of 62 areas of Delhi. Results were analyzed using SPSS and Barlett’s Chi Square Test. Mean arsenic level detected in water samples collected from booster pumping stations was 0.00976 ppm (Range 0.000–0.017 ppm, Standard Deviation 0.006 and Standard error of Mean 0.00118). Maximum arsenic level (0.017 ppm) was found in water samples of booster pumping stations of Mehrauli, Punjabi Bagh and Ramjas Road. Mean arsenic level detected in samples collected from tap water supply was 0.013 ppm (Range 0–0.0430 ppm, Standard Deviation 0.00911 and Standard error of Mean 0.000515). In water samples of 42 areas arsenic level detected was exceeding WHO/EPA permissible limit of 0.01 ppm (10 ppb). The mean arsenic level detected in water samples of booster pumping station was within WHO/EPA permissible limit while mean arsenic level detected in tap water samples was marginally higher. Mixing of ground water and contamination through broken or leaking channel could be the possible reason of higher arsenic level in tap water. Continuous monitoring of quality of drinking water is required particularly in view of water contamination caused by industrial waste and uncontrolled ground water extraction.  相似文献   

分子伴侣与蛋白质折叠   总被引：2，自引：0，他引：2  

井明艳  孙建义 《科技通报》2004,20(5):407-411

新合成的多肽链必须先经折叠和装配后形成特定的三维结构才具有活性．在多肽链折叠过程中，往往会产生折叠异常蛋白，形成集聚体．分子伴侣可有效地调控多肽链的正确折叠，从而避免集聚体的形成．文章主要对分子伴侣的定义、作用、种类、特性等做一介绍。  相似文献   

Application of a transversal laguerre network in adaptive equalization     

K.M. Wong  Y.G. Jan  F.C. Lee 《Journal of The Franklin Institute》1984,317(2):105-115

Synchronous data transmission systems that transmit information over dispersive channels often employ adaptive equalization techniques in the processing of the received signals. Most equalizers presently used in communication systems are of the tapped delay line (TDL) type. In this paper, we propose a class of adaptive equalizers of which the TDL equalizer is a member. Another interesting member of this class is the Laguerre adaptive equalizer which is to be introduced in this paper. The configuration of the Laguerre equalizer is developed. It is found, as shown by the examples, that the Laguerre equalizer is more accurate, and is less sensitive to timing error than the conventional TDL equalizer.  相似文献   

Ultrasonic delay lines     

EMSLIE AG  HUNTINGTON HB 《Journal of The Franklin Institute》1948,245(2):101-115

This paper deals with the experimental aspects of ultrasonic delay lines in liquid media and is a sequel to a previous paper treating the general theory of such devices.Delay devices employing ultrasonic propagation through liquids have proved satisfactory for delay times of the order of 3 milliseconds or less. Such devices can be made broadband and give excellent reproduction of pulse shape. The design considerations for such devices are discussed and illustrated by actual examples.  相似文献   

Estimation of 2-D ARMA model parameters by using equivalent AR approach     

Ayd?n K?z?lkaya 《Journal of The Franklin Institute》2005,342(1):39-67

In this paper, the problem of estimating the parameters of a two-dimensional autoregressive moving-average (2-D ARMA) model driven by an unobservable input noise is addressed. In order to solve this problem, the relation between the parameters of a 2-D ARMA model and their 2-D equivalent autoregressive (EAR) model parameters is investigated. Based on this relation, a new algorithm is proposed for determining the 2-D ARMA model parameters from the coefficients of the 2-D EAR model. This algorithm is a three-step approach. In the first step, the parameters of the 2-D EAR model that is approximately equivalent to the 2-D ARMA model are estimated by applying 2-D modified Yule-Walker (MYW) equation to the process under consideration. Then, the moving-average parameters of the 2-D ARMA model are obtained solving the linear equation set constituted by using the EAR coefficients acquired in the first step. Finally, the autoregressive parameters of the 2-D ARMA model are found by exploiting the values obtained in first and second steps. The performance of the proposed algorithm is compared with other 2-D ARMA parameter and spectral estimation algorithms available in the technical literature by means of three different criteria. As a result of this comparison, it is shown that the parameters and the corresponding power spectrums estimated by using the proposed algorithm are converged to the original parameters and the original power spectrums, respectively.  相似文献   

Transform domain technique for windowing the DCT and DST     

B.G. Sherlock  Y.P. Kakad 《Journal of The Franklin Institute》2002,339(1):111-120

In this paper, an algorithm is developed to apply Hann, Hamming, Blackman and related windows directly in the transform domain for the discrete cosine transform and discrete sine transform. These algorithms are useful in applications where windowing is required in order to minimize edge effects caused by implicit symmetries in the transform domain that are not replicated in the real-world data. Examples of such applications include data communication, adaptive system identification and filtering, real-time analysis of financial market data, etc. Software implementations in C language are also given.  相似文献   

Kant's two paths of knowledge creation: a priori vs a posteriori     

Müller-Merbach  Heiner 《知识管理研究与实践》2007,5(1):64-65

Knowledge Management Research & Practice -  相似文献