A further contribution to the modelling of multi-waveform generators     

B.Z. Kaplan  K. Radparvar 《Journal of The Franklin Institute》1983,316(4):353-360

A method has been presented in recent papers for deriving precisely stabilized waveform generators by relating them to second-order conservative oscillators. The present paper suggests a method for considerably generalizing the previous class ofgenerator models. This should enable the development of a larger variety of waveform generators with ease and flexibility. The new method is analyzed and is shown to possess implications to theoretical biology and other fields.  相似文献   

Fluorescent probes: a new way to study lymphocyte activation     

Richard C. Nairn M.D.  Ph.D.  F.R.C.Path.  F.R.C.P.A.  F.R.A.C.P.  F.R.S.E.  Jennifer M. Rolland B.Sc.  Ph.D. 《Endeavour》1981,5(4):167-171

Fluorescent dyes can be used as cell probes which bind, according to their chemical structure, to particular subcellular regions of lymphocytes. Because of their sensitivity to variations in the local molecular environment, expressed by changes in fluorescence emission, they provide a means of studying the early events of lymphocyte activation to antigens and mitogens. The technology also yields a rapid assay of lymphocyte activation and thus new diagnostic tests of cell-mediated immunity, for example to organ transplants and to cancer.  相似文献   

外国直接投资对于中国技术创新作用的影响分析   总被引：11，自引：0，他引：11  

薄文广马先标  冼国明 《中国软科学》2005,(11):45-51

本文运用我国29个省、市、自治区从1995到2003年的面板数据定量地评估了外国直接投资对我国技术创新（用专利申请量来表征）作用的影响.结论认为：FDI对于中国的技术创新会发挥积极的影响,但前提是要跨越一定的人力资本门槛;FDI对我国外观设计的专利申请量影响程度最大,而对发明专利申请量影响最小,对实用新型的专利申请量影响次之;另外FDI对中国技术创新的影响也存在着明显的区域性特征,FDI对东部地区专利申请量的影响要强于对中部地区的影响,而FDI对于西部地区的专利申请量几乎没有影响.  相似文献   

Evaluating the NASA small business innovation research program: preliminary evidence of a trade-off between commercialization and basic research     

Robert B Archibald  David H Finifter 《Research Policy》2003,32(4):605-619

In 1982, the Small Business Innovation Development Act established the small business innovation research (SBIR) program. This program reserves a percentage of federal agencies’ extramural R&D budgets for research projects conducted by small businesses. When this Act was reauthorized in 1992, the selection criteria for funding dramatically increased the likelihood of funding for projects that promised to lead to commercial success. Using data from a survey of the SBIR program award recipients at NASA Langley Research Center, we address three questions about this change: (i) was there a shift to projects with more commercial potential? (ii) did these projects experience higher rates of commercial success? and (iii) was there a reduction in basic research accompanying the increased commercial success? Our analysis suggests, the answer to all three of these questions is ‘yes’.  相似文献   

Thomas S. Kuhn (18 July 1922-17 June 1996)   总被引：1，自引：0，他引：1  

Edge D  Harré R  Brown A  Barnes B  Mulkay M  Fuller S  Rudwick M  Giere RN  Bloor D 《Social studies of science》1997,27(3):483-502

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A theory for decoupling lossless coupled tapered lines with applications to directional couplers     

M.N.S. Swamy  B.B. Bhattacharyya  S.N. Verma 《Journal of The Franklin Institute》1975,299(6):381-398

A simple theory is presented for decoupling a pair of lossless coupled nonuniform transmission lines (CNUTL), with a common return and supporting TEM waves, into two lossless nonuniform transmission lines (NUTL). This theory is independent of the port terminations, symmetry conditions, etc. The method directly relates the line parameters of the lossless CNUTL's to those of the decoupled lines and vice versa; further, the matrix parameters of the CNUTL's as a four-port are explicitly expressed in terms of those of the decoupled lines as two-ports. This theory is then utilized to study the applications of CNUTL's as directional couplers.It is shown that for CNUTL's to behave as a codirectional coupler, each of the decoupled lines should be a proportional line, while for contradirectional coupler action, the two decoupled lines have to be duals of each other. The coupling response of the codirectional coupler is found to be periodic, while the phase shift between coupled and transmitted signals varies linearly with frequency. The coupling response of various contradirectional couplers with smooth transition at one of the ends, for which the decoupled lines are “basic NUTL's with hyperbolic solutions”, are studied in detail. It is shown that all these couplers have a high-pass response and that the CNUTL's with “hyperbolic cosine squared lines” as decoupled lines have the best response of all the CNUTL's considered.  相似文献   

Detection of enzymes dehydrogenases and proteases inBrugia malayi filarial parasites     

Y. P. Bhandary  K. N. Krithika  Sandeep Kulkarni  M. V. R. Reddy  B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2006,21(1):1-7

Lymphatic filariasis caused mainly by infection fromW. bancrofti andB. malayi remains a major cause of clinical morbidity in tropical and subtropical countries. Analysis ofB. malayi mf, infective larval and adult worm lysates for the activity of enzymes led to the demonstration of activities of three key enzymes of carbohydrate metabolism viz., Malate dehydrogenase (MDH), Malic enzyme (ME) and Glucose-6-phosphate dehydrogenase (G6PDH) in all the three stages of the parasite. The specific activity of all the three dehydrogenases was significantly high in mf lysate compared to their activity in lysates of the other two stages (P<0.001). Analysis by native polyacrylamide gel to their activity inlysates of the other two stages (P<0.001). Analysis by native polyacrylamide gel electrophoresis (PAGE) using 7.5% non-gradient gel showed the presence of two isoforms of each of the three enzymes (MDH, ME & G6PDH) in mf lysate, while only one form of each enzyme was present in L₃ larval and adult worm lysates. Further proteolytic enzyme activity was demonstrated both in microfilarial and infective larval lysates ofB. malayi. While both mf and L₃ larval lysates showed optimal protease activity at alkaline pH of 9.0, the mf lysate showed increased activity also at pH 3.0. The infective larval lysate was markedly inhibited by Tosylamide-L-Phenylalanine chloromethyl ketone (TPCK), a thiol protease inhibitor, while the protease activity in mf lysate was significantly inhibited by both TPCK and a serine protease inhibitor Phenyl Methyl Sulphonyl Flouride (PMSF). In sodium do-decyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), using gelatin copolymerized gel, the microfilarial lysate showed 3 protease molecules of 40 kDa, 180 kDa and 200 kDa and the L₃ larval lysate had 6 protease molecules of 18, 25, 37, 49, 70 and 200 kDa size.  相似文献   

Application of tumor markers in ovarian malignancies     

T. Malati  G. Rajani Kumari  B. Yadagiri 《Indian journal of clinical biochemistry : IJCB》2001,16(2):224-233

Ovarian cancer is the fifth leading cause of death in women. The incidence of this malignancy increases in women over the age of 40. The overall five years survival is less than 30%, as most women present with advanced stage disease. Until recently, detection of early stage ovarian cancer has been difficult since it is usually nonpalpable and asymptomatic. The definitive diagnosis of an ovarian mass is a common problem in gynecologic patients with adnexal mass. The routine standard evaluation for adnexal masses includes patient's history, physical examination, ultrasound and histopathological examination. These parameters individually or in combination have little predictive value. The accuracy of diagnostic tools are of immense value and great concern to practicsing Gynecologists and Oncologists. The clinical application of serum concentration of CA 125, AFP and hCG is of great help not only as diagnostic aid but also in monitoring efficacy of any treatment modality like chemotherapy, radiotherapy or surgical resection. Additionally, evaluation of tumor marker concentration helps in predicting early biochemical recurrence and in prognostication in different types of ovarian malignancies. The ability to differentiate a malignant mass from a benign pelvic mass pretherapeutically could be enhanced optimally by additional use of tumor markers such as cancer antigen CA-125, alphafetoprotein and human chorionic gonadotrophin in pre-and postmenopausal women.  相似文献   

Effects of axial conduction in laminar tube flow with convective boundaries     

B. Vick  M.N. Özişik  D.F. Ullrich 《Journal of The Franklin Institute》1983,316(2):159-173

Heat transfer in laminar tube flow with convective boundary conditions and axial heat conduction in the fluid is solved exactly. The effects of the external Biot numbers and the axial conduction in fluid on the temperature distribution and the local Nusselt number are determined for both the upstream and the downstream regions. In order to illustrate the effects of velocity profile, the results for the slug flow and the parabolic velocity profiles are plotted simultaneously. The heat transfer characteristics of the flow are found to be rather sensitive to the Péclét number, the external Biot numbers and the velocity profile in the thermal entrance region.  相似文献   

Do University policies make a difference?     

David B. Audretsch  Erik E. Lehmann 《Research Policy》2005,34(3):343-347

The purpose of this paper is to examine whether the technical universities have been more successful in facilitating the spillover and commercialization of knowledge. We compare the impact of technical and general universities on the performance of knowledge-based firms. Based on a unique data set consisting of publicly held high technology firms, the empirical evidence suggests that, in fact, firm performance is not influenced by the type of university. Technical universities do not have a differential impact on firm performance from more general universities.  相似文献