Isolation and culture of Leydig cells from adult rats     

R. S. Sharma  P. C. Pal  M. Rajalakshmi 《Indian journal of clinical biochemistry : IJCB》2006,21(1):27-33

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Acid base status in chronic obstructive pulmonary disease patients     

Varinder Saini  Narinder Saini  Jasbinder Kaur  G. P. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):36-38

348 patients of chronic obstructive pulmonary diseases (COPD) were studied for their acid base profile using ABL-3 blood gas analyser (Radiometer, copenhagan). 185 patients (53.1%) had simple disorders (respiratory acidosis—53%, respiratory alkalosis—25.4%, metabolic acidosis—11.3%, metabolic alkalosis—10.2%). Mixed disorders were present in 131 patients (34.9%) (respiratory acidosis and metabolic acidosis—75.2%, respiratory acidosis and metabolic acidosis—14%, metabolic acidosis and metabolic alkalosis—5.7%, metabolic alkalosis and respiratory alkalosis—4.9%). Hypoxemia without other acid base abnormalities was observed in early patients of GOPD (42 patients—12%). Chronic respiratory acidosis was the most common finding in advanced cases of COPD (98%). An almost equal number of such patients had a mixed disorder of respiratory acidosis with metabolic alkalosis (91%). Salt restriction, prolonged use of steriods and hypokalemia were often related to metabolic alkalosis in such patients.  相似文献   

Lipid peroxidation and antioxidant vitamins in urolithasis     

J Kato  Alice Abraham Ruram  S Sekharjit Singh  S Bilasini Devi  Th Ibetombi Devi  W Gyaneshwar Singh 《Indian journal of clinical biochemistry : IJCB》2007,22(1):128-130

The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid peroxidation and antioxidant vitamins-vitamins A, vitamin C and vitamin E in 75 confirmed cases of urolithiasis. Significantly high level of MDA (p<0.001) with significantly low levels of vitamin E (p<0.001) and vitamin A (p<0.001) with no significant decrease in vitamin C (p>0.05) were observed in the plasma of urolithiasis cases as compared to normal controls. In conclusion, it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis. But, the exact mechanism how this occurs remains to be elucidated.  相似文献   

Serum and urinary zinc in zinc miners and zinc smelters     

P. P. Singh  K. H. Komleh  A. K. Pendse  Rajkiran  R. C. Gupta 《Indian journal of clinical biochemistry : IJCB》1992,7(1):57-59

Serum (200.6±64.8 mg/dl) and urinary zinc (1186.0±265.5 mg/l.) of zinc miners at Zawar were significantly higher as compared to zinc smelter workers (Serum 89.7±9.9. mg/dl; Urine 590.0±32.1 mg/l.). Debari and Udaipur residents (Serum 104.0±18.6 mg/dl; Urine 735.0±180.2 mg/l.). This was most likely attributable to higher dietary zinc intake by zinc miners due to higher zinc content of foodstuffs grown in Zawar areas as compared to Debari and Udaipur.  相似文献   

Regional Distribution of Copper,Zinc and Iron in Brain of Wistar Rat Model for Non-Wilsonian Brain Copper Toxicosis     

Amit Pal  Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2016,31(1):93-98

In previous studies, we have reported first in vivo evidence of copper deposition in the choroid plexus, cognitive impairments, astrocytes swelling (Alzheimer type II cells) and astrogliosis (increase in number of astrocytes), and degenerated neurons coupled with significant increase in the hippocampus copper and zinc content in copper-intoxicated Wistar rats. Nonetheless, hippocampus iron levels were not affected by chronic copper-intoxication. Notwithstanding information on distribution of copper, zinc and iron status in different regions of brain due to chronic copper exposure remains fragmentary. In continuation with our previous study, the aim of this study was to investigate the effects of intraperitoneally injected copper lactate (0.15 mg Cu/100 g body weight) daily for 90 days on copper, zinc and iron levels in different regions of the brain using atomic absorption spectrophotometry. Copper-intoxicated group showed significantly increased cortex, cerebellum and striatum copper content (76, 46.8 and 80.7 % increase, respectively) compared to control group. However, non-significant changes were observed for the zinc and iron content in cortex, cerebellum and striatum due to chronic copper exposure. In conclusion, the current study demonstrates that chronic copper toxicity causes differential copper buildup in cortex, cerebellum and striatum region of central nervous system of male Wistar rats; signifying the critical requirement to discretely evaluate the effect of copper neurotoxicity in different brain regions, and ensuing neuropathological and cognitive dysfunctions.  相似文献   

Effect of thiazide drug compound on the testicular protein and cholesterol contents of albino rat     

Hemlata Yadav  P. K. Singh 《Indian journal of clinical biochemistry : IJCB》2003,18(2):206-208

In this study the effect of thiazide diuretic compound on the protein and cholesterol contents in the testes of albino rats as the experimental model. The drug thiazide was administered orally daily for 10,20 and 30 days at the dose of 100mg/kg body weight. Total protein decrease in the testes of rats were evidenced may be due to the side effects of thiazide drug compound which is linked with the hyponatremia and protein metabolism. An elevated level of cholesterol contents observed in thiazide treated rats also revealed that the side effect of drug compound thiazide and also may be due to the stimulation of catecholamine which is stimulated therefore, the biochemical estimation such as protein and cholesterol in the testes after the thiazide treatment determined the effectiveness of diuretic drug compound would provide clinical evidences of their side effects.  相似文献   

Rethinking the Boundaries of Cognitive Load Theory in Complex Learning     

Kalyuga  Slava  Singh  Anne-Marie 《Educational Psychology Review》2016,28(4):831-852

Educational Psychology Review - In the traditional framework of cognitive load theory, it is assumed that the acquisition of domain-specific knowledge structures (or schemas) is the only...  相似文献   

Group Identity,Individual Autonomy and Education for Human Rights   总被引：1，自引：0，他引：1  

B. R. Singh 《Educational studies》1994,20(1):87-103

The United Nations Declarations of Human Rights (1948) express an ideal for the protection of cultural rights of everyone. They propose an education that is multicultural and non‐discriminatory and recognise that parents have the right to choose their children's education. Article 13.3 of the International covenant on Economic and Social and Cultural Rights gave parents the right to choose for their children “schools other than those established by public authorities to ensure the religious and moral education of their children in conformity with their own convictions”. The paper feels uneasy with this principle that grants parents the right to educate their children in conformity with their own convictions. Such rights could result in restricting the education of children to the narrow framework of parental beliefs and values that could be antithetical to social harmony, individual autonomy and equal opportunity. The question is, should such a right be extended to all parents including those who believe in racial superiority, in apartheid, Nazism or Fascism or in the inherent intellectual differences between boys and girls? The paper discusses some of these issues and asks how can the best interests of the child be served in a pluralist, multicultural, multiracial society. The paper acknowledges that in a pluralistic democratic society there will always be tensions between the public interests, the interests of the group and the interests or autonomy of the individual. These interests are discussed within the framework of fundamental human rights, common or separate schooling and multicultural education. The paper sees these as interrelated issues which are connected with group identity and equal opportunity. Where these interrelated issues conflict, the paper takes the stance that the rights and the autonomy of the individual should take precedence over the others, especially if the notion of human rights and human dignity is to be preserved in practice. This is obviously a controversial issue and the hope is that the paper will open up these issues for further discussion and debate.  相似文献   

Intergenerational Communication in Immigrant Punjabi Families: Implications for Helping Professionals     

Kamala Elizabeth Nayar  Jaswinder Singh Sandhu 《International journal for the advancement of counseling》2006,28(2):139-152

This paper is an extension of the primary author’s post-doctoral research on the Sikh diaspora in Vancouver, Canada. Drawing upon the orality, literacy and ‘analytics’ (critical inquiry) paradigm, the paper delineates the distinctive communication patterns that characterize each of three generations in the Punjabi community in that location. A sample intergenerational dialogue in the counselling context is provided to demonstrate the nature of fluidity in communication, and the implications for helping professionals are discussed.  相似文献   

‘Whatever she may study,she can’t escape from washing dishes’: gender inequity in secondary education – evidence from a longitudinal study in India     

Renu Singh  Protap Mukherjee 《Compare》2018,48(2):262-280

Using unique panel data from Young Lives study conducted in undivided Andhra Pradesh, India, this mixed-method paper analyses gender differentials in completion of secondary education. Results show biased secondary school completion rates in favor of boys. Probit regression results highlight certain variables such as mothers’ education, wealth, high self-efficacy, early reading skills, lower birth order, and not engaging in more than two hours of domestic work and paid work at age 12, as positively associated with educational outcomes for girls. Decomposition analysis highlights that engaging in domestic chores at age 12 is the most contributory factor (36%) for the persisting gender gap. The other unexplained contributory factors may well be existing discriminatory social norms and son preference, which is captured by the qualitative case studies. The findings suggest that unless we are able to address persisting gender norms, universalizing secondary education with gender equity, will remain a distant dream.  相似文献