Urinary Urea,Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients     

Hanaa B. Atya  Sahar A. Ali  Mohamed I. Hegazy  Fathia Z. El Sharkawi 《Indian journal of clinical biochemistry : IJCB》2018,33(2):163-170

Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression.  相似文献   

Raising teachers’ voices: an in-depth qualitative inquiry into teachers’ working conditions and professional development needs in Khyber Pakhtunkhwa,a province of Pakistan     

Takbir Ali 《Teacher Development》2018,22(1):78-104

This study documented in detail teachers’ voices about their working conditions, professional development needs and opportunities to cater to these needs. The study reported in this paper was conducted as part of a large-scale study that used mixed methods to assess teachers’ professional development needs. The qualitative data reported in this paper were collected using focus group discussion with teachers (N = 481), classroom observation (N = 66), post-observation interviews with teachers (N = 24) and analysis of qualitative responses from survey questionnaires (N = 200). By bringing together a collection of teachers’ voices, the findings of the study illuminate a hope for positive change in teaching and learning in public schools in Khyber Pakhtunkhwa, provided that teachers are genuinely considered as part of the solution and are facilitated with necessary physical and structural resources and psychological incentives. The education system needs to create conditions in schools that support teachers’ work and their continued professional growth.  相似文献   

Rank one chaos in a switch-controlled Chua's circuit     

Ali Oksasoglu  Quidong Wang 《Journal of The Franklin Institute》2010,347(9):1598-1622

In this paper, we study the existence of strange attractors in a switch-controlled Chua's circuit. This circuit is obtained from the original Chua's circuit by adding externally controlled switches to it in such a way to modulate the system state variables. This investigation is conducted from the perspective of a recent chaos theory of rank one maps. The externally controlled switches are used for the purposes of realizing the general settings of the theory. Both synchronous and asynchronous switch control schemes providing periodic kicks in various directions are investigated, and their effects on the resulting chaotic attractors are discussed. The results of the numerical simulations presented are in close agreement with the expectations of the theory.  相似文献   

Dielectrophoretic separation of mouse melanoma clones     

Ahmet C. Sabuncu  Jie A. Liu  Stephen J. Beebe    Ali Beskok 《Biomicrofluidics》2010,4(2)

Dielectrophoresis (DEP) is employed to differentiate clones of mouse melanoma B16F10 cells. Five clones were tested on microelectrodes. At a specific excitation frequency, clone 1 showed a different DEP response than the other four. Growth rate, melanin content, recovery from cryopreservation, and in vitro invasive studies were performed. Clone 1 is shown to have significantly different melanin content and recovery rate from cryopreservation. This paper reports the ability of DEP to differentiate between two malignant cells of the same origin. Different DEP responses of the two clones could be linked to their melanin content.  相似文献   

中国足协处罚权研究          下载免费PDF全文

邓小兵  王阿丽 《河北体育学院学报》2021,35(6):36-43

中国足协的处罚权是其参与体育治理的重要手段,相较于法定性强、形态有限的行政处罚, 更具专业性和针对性。为了保障其良性运转,维护相对人的诉讼权利,司法权的适度介入已成为理论界的共识。但我国传统的行政主体理论不能回应这种社会公权力发展的现实需要,并对其作出合理解释。因此,亟需重构我国的行政主体理论,赋予中国足协行政主体地位,构建司法审查规则,即法院审查足协处罚权时应当遵循仲裁优先原则、穷尽内部救济原则、法律审查原则;在审查范围上,除了审查足协处罚行为,还应当附带审查处罚规则。  相似文献   

21st Century experiences in the development of school-based management policy and practices in Indonesia     

Bandur  Agustinus  Hamsal  Mohammad  Furinto  Asnan 《Educational Research for Policy and Practice》2022,21(1):85-107

Educational Research for Policy and Practice - Since 2001, Indonesian schools have implemented a mandatory school-based management (SBM) policy for better quality education in general and more...  相似文献   

Combining management training and technical training in an international setting     

William Fisher  Ali Kamel Ali 《Performance Improvement》1992,31(9):27-31

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Interactive cube for effective demonstration of virtual periodic table     

Ali  Numan  Ullah  Sehat  Raees  Muhammad 《Education and Information Technologies》2022,27(2):1635-1654

Education and Information Technologies - Virtual Periodic Table (VPT) is an effective software tool to present elements in a conceivable three-dimensional (3D) mode. VPT is used to assist users in...  相似文献   

Multimodal learning analytics—In-between student privacy and encroachment: A systematic review     

Paul Prinsloo  Sharon Slade  Mohammad Khalil 《British journal of educational technology : journal of the Council for Educational Technology》2023,54(6):1566-1586

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Understanding privacy and data protection issues in learning analytics using a systematic review     

Qinyi Liu  Mohammad Khalil 《British journal of educational technology : journal of the Council for Educational Technology》2023,54(6):1715-1747

The field of learning analytics has advanced from infancy stages into a more practical domain, where tangible solutions are being implemented. Nevertheless, the field has encountered numerous privacy and data protection issues that have garnered significant and growing attention. In this systematic review, four databases were searched concerning privacy and data protection issues of learning analytics. A final corpus of 47 papers published in top educational technology journals was selected after running an eligibility check. An analysis of the final corpus was carried out to answer the following three research questions: (1) What are the privacy and data protection issues in learning analytics? (2) What are the similarities and differences between the views of stakeholders from different backgrounds on privacy and data protection issues in learning analytics? (3) How have previous approaches attempted to address privacy and data protection issues? The results of the systematic review show that there are eight distinct, intertwined privacy and data protection issues that cut across the learning analytics cycle. There are both cross-regional similarities and three sets of differences in stakeholder perceptions towards privacy and data protection in learning analytics. With regard to previous attempts to approach privacy and data protection issues in learning analytics, there is a notable dearth of applied evidence, which impedes the assessment of their effectiveness. The findings of our paper suggest that privacy and data protection issues should not be relaxed at any point in the implementation of learning analytics, as these issues persist throughout the learning analytics development cycle. One key implication of this review suggests that solutions to privacy and data protection issues in learning analytics should be more evidence-based, thereby increasing the trustworthiness of learning analytics and its usefulness.

Practitioner notes

What is already known about this topic

• Research on privacy and data protection in learning analytics has become a recognised challenge that hinders the further expansion of learning analytics.
• Proposals to counter the privacy and data protection issues in learning analytics are blurry; there is a lack of a summary of previously proposed solutions.

What this study contributes

• Establishment of what privacy and data protection issues exist at different phases of the learning analytics cycle.
• Identification of how different stakeholders view privacy, similarities and differences, and what factors influence their views.
• Evaluation and comparison of previously proposed solutions that attempt to address privacy and data protection in learning analytics.

Implications for practice and/or policy

• Privacy and data protection issues need to be viewed in the context of the entire cycle of learning analytics.
• Stakeholder views on privacy and data protection in learning analytics have commonalities across contexts and differences that can arise within the same context. Before implementing learning analytics, targeted research should be conducted with stakeholders.
• Solutions that attempt to address privacy and data protection issues in learning analytics should be put into practice as far as possible to better test their usefulness.

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