Medicinal plants for treatment of diabetes mellitus     

R. Shukia  S. B. Sharma  D. Puri  K. M. Prabhu  P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2000,15(1):169-177

Many plants have been used for the treatment of diabetes mellitus in Indian system of medicine and in other ancient systems of the world. Out of these only a few have been evaluated as per modern system of medicine. From many such plants only extracts have been prepared and their usefulness evaluated in experimental diabetes in animals. In some plants likeAllium cepa, Allium sativum, Ficus bengalensis, Gymnema sylvestre, Pterocarpus marsupium etc. active hypoglycemic principles have been isolated and their mechanism of action studied. Most of them seem to act directly on pancreas (pancreatic effect) and stimulate insulin level in blood. Some have extra pancreatic effect also by acting directly on tissues like liver, muscle etc. and alter favourably the activities of the regulatory enzymes of glycolysis, gluconeogenesis and other pathways. Since the plant products have less side effects, they have the potential as good hypoglycemic drugs. They may also provide clues for the development of new and better oral drugs for diabetes.  相似文献   

Serum apolipoproteins in the patients of myocardial infarction in different age groups     

R. Sharma  V. S. Singh 《Indian journal of clinical biochemistry : IJCB》2001,16(1):122-126

The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol (LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31–40 years and 41–50 years and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid parameters.  相似文献   

Modulation of convulsive threshold of pentylene tetrazole by zinc     

N. Khanna  A. Garg  K. K. Sharma  R. Khosla 《Indian journal of clinical biochemistry : IJCB》1997,12(1):86-90

In the present study which was aimed to see the effect of zinc on pentylenetetrazole induced convulsive threshold in rats we found that zinc sulfate 100 μg intracerebroventricularly) and pentylenetetrazole (50 mg/kg intraperitoneally) produced dose related seizure activity; however, pretreatment with zinc decreased the threshold, increased the severity, incidence of multiple seizures and total duration of pentylenetetrazole induced seizures. Diazepam (5 mg/kg intraperitoneally) pretreatment increased the threshold and lowered the incidence of convulsions in zinc induced seizures which further confirms that the convulsive effect of zinc is through inhibition of gamma aimino butyric acid.  相似文献   

A preliminary report on the role of yoga asanas on oxidative stress in non-insulin dependent diabetes mellitus     

Savita Singh  Varun Malhotra  K. P. Singh  S. B. Sharma  S. V. Madhu  O. P. Tandon 《Indian journal of clinical biochemistry : IJCB》2001,16(2):216-220

Nineteen subjects of non-insulin dependent diabetes mellitus (NIDDM) between the age group of 30–60 yrs were studied to see the effect of specific yoga asanas on fasting and postprandial blood glucose (FBG, PPG), serum malondialdehyde (MDA) and glycosylated hemoglobin (HbA₁) in addition to drug treatment and diet control. The duration of diabetes ranged from 1–10 years. Patients with renal, cardiac and proliferative retinal diseases were excluded from the study. The same patients served as their own control. Subjects were called in the morning to the cardio-respiratory laboratory and were given training by a yoga expert. Yoga asanas included Suryanamskar, Tadasan, TriKonasan, Padmasan, Pranayam, Paschimottanasan, Ardhmatsyendrasan, Pavanmukthasan, Sarpasan and Shavasan. The asanas were done every day for 40 days for 30–40 min. FBG, PPG, serum MDA and HbA₁ were estimated before and after 40 days of yoga asanas regimen. Significant reduction was seen in FBG from 220 mg/dl to 162 mg/dl, PPG from 311 mg/dl to 255 mg/dl, MDA from 6 nmol/l to 3 nmol/l and HbA₁, from 8.8% to 6.4%. Subjects felt better and were relieved of their stresses and had an improvement in their day to day performance. The decrease was statistically significant (p<0.0001 for FBG and PPG, p<0.001 for MDA and for HbA₁).  相似文献   

Study on arsenic level in public water supply of Delhi using hydride generator accessory coupled with atomic absorption spectrophotometer   总被引：1，自引：0，他引：1  

Sanjeev Lalwani  T. D. Dogra  D. N. Bhardwaj  R. K. Sharma  O. P. Murty 《Indian journal of clinical biochemistry : IJCB》2006,21(1):70-76

Exposure to arsenic has been associated with several health hazards. Worldwide the main reason for chronic human intoxication with arsenic is intake of contaminated drinking water. Air acetylene type of atomic absorption spectrophotometer in combination with hydride generator accessory was used to analyze arsenic level in 25 water samples collected from 25 booster pumping stations and 313 water samples collected from tap water supply of 62 areas of Delhi. Results were analyzed using SPSS and Barlett’s Chi Square Test. Mean arsenic level detected in water samples collected from booster pumping stations was 0.00976 ppm (Range 0.000–0.017 ppm, Standard Deviation 0.006 and Standard error of Mean 0.00118). Maximum arsenic level (0.017 ppm) was found in water samples of booster pumping stations of Mehrauli, Punjabi Bagh and Ramjas Road. Mean arsenic level detected in samples collected from tap water supply was 0.013 ppm (Range 0–0.0430 ppm, Standard Deviation 0.00911 and Standard error of Mean 0.000515). In water samples of 42 areas arsenic level detected was exceeding WHO/EPA permissible limit of 0.01 ppm (10 ppb). The mean arsenic level detected in water samples of booster pumping station was within WHO/EPA permissible limit while mean arsenic level detected in tap water samples was marginally higher. Mixing of ground water and contamination through broken or leaking channel could be the possible reason of higher arsenic level in tap water. Continuous monitoring of quality of drinking water is required particularly in view of water contamination caused by industrial waste and uncontrolled ground water extraction.  相似文献   

Astudy on mycobacterial proteins in the serodiagnosis of tuberculosis using ELISA and western blot     

Ajay Kumar  T. A. Venkita Subramanian  Usha P. Sharma 《Indian journal of clinical biochemistry : IJCB》1992,7(2):165-168

Protein fraction termed P₂ was obtained from sonicates of Mycobacterium smegmatis, subjected to ammonium sulphate precipitation. P₂ fraction was further fractionated into 4 fractions (PeakI-IV) by DEAE cellulose ion-exchange chromatography. ELISA was performed on the sera of 104 tuberculous cases and 62 controls, using P₂ fractions Peak I as test antigens. Though the mean ELISA values in tuberculous cases were higher than the controls, no statistically significant difference was found between the two. Antigens P₂, Peak I and IV were tested on Western blots with pooled sera from tuberculous cases as well as controls. P₂ fraction, Peak-I and IV were separated on PAGE-SDS, electroblotted onto nitrocellulose Sheets and the blots were subjected to ELISA. Peak IV appeared as a single band (M.W. 55,000). P₂ fraction exhibited some discriminatory bands on development of blots.  相似文献   

Hyperlipidemia in guinea pigs induced by chronic vitamin C deficiency     

Praveen Sharma  P. K. Sharma D.Sc.  J. Pramod  L. K. Kothari  Rashmi Ranka  Sushma Sharma 《Indian journal of clinical biochemistry : IJCB》1989,4(1):62-64

Sixteen weeks of chronic vitamin C deficiency, induced in guinea pigs by restricted vitamin C intake, resulted in a marked increase in the serum total LDL- and VLDL- cholesterol, triglycerides and total lipids. HDL-cholesterol decreased resulting in a highly significant increase in LDL/HDL ratio. The results reconfirm that vitamin C deficiency causes changes in blood lipid profile which could promote atherogenesis.  相似文献   

Rethinking learning for a digital age – Edited by Rhona Sharpe et al     

Ramesh C Sharma 《British journal of educational technology : journal of the Council for Educational Technology》2011,42(4):E85-E86

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The views of Pasifika students in New Zealand about communicating mathematically     

Sashi Sharma  Jenny Young-Loveridge  Merilyn Taylor  Ngärewa Häwera 《Asia Pacific Journal of Education》2011,31(4):503-519

This paper focuses on the perspectives of Years 7 and 8 Pasifika students on mathematics learning, in particular their views about the communication of solution strategies with others (their peers), and their teacher. Pasifika students' ideas about the importance of communicating their mathematical reasoning and strategies to peers and teachers were analysed and themes identified. While most students were in agreement about the importance of explaining their thinking to others, there was considerable variation in the reasons they gave for their views. The findings are interpreted in relation to socio-cultural theory and recent writing about requirements for citizenship in the twenty-first century.  相似文献   

Relationship of Brain-Derived Neurotrophic Factor with Interleukin-23, Testosterone and Disease Severity in Schizophrenia     

Priya Allimuthu  Hanumanthappa Nandeesha  Raghavi Chinniyappan  Balaji Bhardwaz  Jesudas Blessed raj 《Indian journal of clinical biochemistry : IJCB》2021,36(3):365

Hormonal imbalance, inflammation and alteration in synaptic plasticity are reported to play a crucial role in the pathogenesis of schizophrenia. The objective of the study was to assess the serum levels of brain derived neurotrophic factor (BDNF) and its association with interleukin-23 (IL-23), testosterone and disease severity in schizophrenia. 40 cases and 40 controls were included in the study. Serum levels of BDNF, IL-23 and testosterone were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS). The study was designed in Tertiary care hospital, South India. The results were compared between two groups using Mann–Whitney U test. Spearman Correlation analysis was used to assess the association between biochemical parameters and PANSS. Interleukin-23 and testosterone were significantly increased and BDNF was significantly reduced in schizophrenia cases when compared with controls. BDNF was negatively correlated with IL-23 (r = − 400, p = 0.011), positive symptom subscale (r = − 0.393, p = 0.012), general psychopathology score subscale (r = − 407, p = 0.009) and total symptom subscale (r = − 404, p = 0.010). There was no significant association of IL-23 and testosterone with disease severity in schizophrenia cases. BDNF was reduced in schizophrenia cases and negatively associated with interleukin-23 and disease severity scores.  相似文献