Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver     

Sharma A  Sharma KK 《Indian journal of clinical biochemistry : IJCB》2011,26(3):290-295

The present study was carried out to investigate the protective role of Triphala (a combination in equal proportions by weight of fruit powder of Terminalia belerica, Terminalia chebula and Emblica officinalis) against 1,2-dimethylhydrazinedihydrochloride (DMH) induced Endoplasmic reticulum stress (ER stress) in mouse liver. An oral dose of 3 mg/kg body wt in drinking water for 5 weeks significantly (P < 0.001) increased the levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum Alkaline phosphatase (ALP) and total bilirubin thus suggesting damage to mouse liver and biliary dysfunction. The DMH administration invariably led to increase in the liver microsomal proteins of molecular weight of about 29 (ERp29) and 53 kDa (ERp53) and decrease in the protein of molecular weight of 36 kDa (ERp36) thereby suggesting the interference of DMH and its metabolites with normal protein biosynthesis and folding, in the reticular membranes of the liver cells thus developing ER stress. Histological studies show necrosis, large sized hepatocytes with increased N:C ratio, aberrant mitotic figures and prominent nucleoli in the liver of DMH treated mice. In animals fed 5% Triphala in diet (w/w) during DMH administration, there was significant decrease in the above changes in the liver suggesting the suppression of DMH induced ER stress in liver. Triphala significantly (P < 0.05) decreased lipid peroxidation and also the activity of lactate dehydrogenase (LDH) in mouse liver. It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.  相似文献   

Measuring physical activity in preschoolers: Reliability and validity of The System for Observing Fitness Instruction Time for Preschoolers (SOFIT-P)     

Sharma S  Chuang RJ  Skala K  Atteberry H 《Measurement in physical education and exercise science》2011,15(4):257-273

The purpose of this study is describe the initial feasibility, reliability, and validity of an instrument to measure physical activity in preschoolers using direct observation. The System for Observing Fitness Instruction Time for Preschoolers was developed and tested among 3- to 6-year-old children over fall 2008 for feasibility and reliability (Phase I, n=67) and in fall 2009 for concurrent validity (Phase II, n=27). Phase I showed that preschoolers spent >75% of their active time at preschool in light physical activity. The mean inter-observer agreements scores were ≥.75 for physical activity level and type. Correlation coefficients, measuring construct validity between the lesson context and physical activity types with and with the activity levels, were moderately strong. Phase II showed moderately strong correlations ranging from .50 to .54 between the System for Observing Fitness Instruction Time for Preschoolers and Actigraph accelerometers for physical activity levels. The System for Observing Fitness Instruction Time for Preschoolers shows promising initial results as a new method for measuring physical activity among preschoolers.  相似文献   

Revisiting the development of time sharing using a dual motor task performance     

Getchell N  Pabreja P 《Research quarterly for exercise and sport》2006,77(1):131-136

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Sir Ronald Ross and the malarial parasite     

Shobhona Sharma 《Resonance》2006,11(7):4-13

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Vitamin D: The Need of the Hour     

Praveen Sharma  Prasenjit Mitra 《Indian journal of clinical biochemistry : IJCB》2016,31(3):243-244

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A study of thyroid status in hyperemesis gravidarum     

Bhupinder Kaur Gill  Promila Jindal  Raj Kumar  Shweta Tiwari  Namrata Sharma  Anupama Goel 《Indian journal of clinical biochemistry : IJCB》2007,22(1):148-151

Study was undertaken to assess thyroid status in hyperemesis gravidarum. 150 women pregnant with <20 weeks of gestation were selected randomly and out of these 100 women presenting with hyperemesis formed study group while 50 normal pregnant women served as controls. 53% of hyperemetic pregnant women were primigravidae and 82% of pregnant women presented with vomiting at less than 12 weeks of gestation. Statistically significant, 22% of hyperemetic women had increased serum T₃ levels while T₄ levels were increased in 67% of women in study group as compared to 8% and 16% respectively in control group. TSH levels were decreased in 18% of hyperemetic women as compared to 8% in control group with decrease in mean TSH level statistically significant. 22% of hyperemetic women had electrolyte disturbances and 7% were ketonuric. In clinically euthyroid women, biochemically altered thyroid function can attribute to vomiting and its prolongation to second trimester  相似文献   

Influence of alcoholic extract of whole fruit of trichosanthes dioica on blood sugar,serum lipids,lipoproteins and faecal sterols in normal albino rabbits     

Govind Sharma  M. C. Pant 《Indian journal of clinical biochemistry : IJCB》1992,7(1):53-56

Effect of oral administration of 2 ml per day of suspension (in water) of alcoholic extract of whole fruit of Trichosanthes dioica (2%) (=100 g fresh wt.=7 g dry wt.=1/15 g of alcoholic extract) with the help of catheter alongwith basal diet for four weeks have been studied in the normal albino rabbits. It was observed that this extract lowered the blood sugar, total cholesterol, low density lipoprotein cholesterol and triglyceride levels, and increased the high density lipoprotein cholesterol, phospholipid and faecal sterol levels. Such effects are manifested from the very first week of feeding and are statistically significant.  相似文献   

Serum and tissue levels of zinc,copper, magnesium and retinol in prostatic neoplasms     

M. Jain  Kavita Sharma  V. P. Sharma 《Indian journal of clinical biochemistry : IJCB》1994,9(2):106-108

Zinc (Zn), copper (Cu), magnesium (Mg) and retinol levels were studied in serum and tissue of the patients with prostatic carcinoma (Ca), benign hyperplasia (BHP) and control subjects. Zinc and retinol levels were low in both serum and tissues of patients with carcinoma, while in BHP, both zinc and retinol level were decreased. Copper levels were high in serum and tissues of both BHP as well as carcinoma patients. Magnesium levels were elevated in both serum and tissues of cancerous patients. The results indicate that Zn, Cu, and Mg metabolism is disturbed in malignancy.  相似文献   

Emerging problems in Malaria control     

V. P. Sharma 《Indian journal of clinical biochemistry : IJCB》1997,12(1):4-4

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开展机构协作发展远程教育     

肖俊洪 《中国远程教育(综合版)》2004,(7):29-32

[译者按]本文原文发表于"学习联邦"(Com-monwea]th of Learning)网站<知识系列>(Know]-edge Series)栏目(2003年).学习联邦是英联邦各成员国的政府首脑倡议成立的政府间组织,其宗旨是鼓励开发和共享开放学习和远程教育的知识、资源和技术.目前我国远程教育机构也正在开展各种形式的协作,既有电大之间的协作,也有电大与其他教育机构的协作,还有国际间的协作,但毕竟一切刚刚起步,许多地方有待于进一步完善.因此,我们认为这篇经验之谈的文章所提出的一些原则、建议、指南等对我们有一定指导意义和借鉴价值.现将其译成中文,以飨读者,并向印度甘地国立开放大学Sharma高级讲师和Chaudhary教授以及学习联邦组织致谢!  相似文献