When mathematics mattered     

Amir Alexander 《Metascience》2013,22(2):451-453

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Investigation and evaluation of ultrasound reactor for reduction of fungi from sewage     

Dehghani MH  Mahvi AH  Jahed GR  Sheikhi R 《Journal of Zhejiang University. Science. B》2007,8(7):493-497

The objective of the investigation was to study the application of ultrasound reactor technology （USRT） as a disinfectant for reduction of fungi from sewage effluent. Fungi are carbon heterotrophs that require preformed organic compounds as carbon sources. USRT is an attractive means to improve water quality because of the system simplicity and no production of toxic by-products. An ultrasound reactor produces strong cavitation in aqueous solution causing shock waves and reactive free radicals by the violent collapse of the cavitation bubble. These effects should contribute to the physical disruption of microbial structures and inactivation of organisms. There was significant reduction in fungal growth, with decreased fungal growth with increasing USRT. In this study, ultrasound irradiation at a frequency of 42 kHz was used to expose suspensions of fungi to evaluate the disinfection efficacy of the ultrasound reactor. Also, this study showed that in this system more than 99% reduction of sewage fungi was achieved after 60 min.  相似文献   

The study of the success indicators for pre-implementation activities of Iran's E-Government development projects     

Mohammad Sharifi  Amir Manian 《Government Information Quarterly》2010

E-Government and E-Government development project studies have been conducted in most industrialized societies, as well as in Iran. Due to their nature and structure, E-Government development projects have numerous political, social, and economic impacts on society. Given the incorporation of significant capital, human resources, information, and political commitments, these projects are considered quite vital to society. Following the systematic pre-implementation activities of E-Government development projects is critical for the success of such projects; ignoring such issues leads to various problems during E-Government project implementation. This research aims to explore and detect the success indicators for pre-implementation activities of E-Government development projects, evaluate the validity of these indicators, and investigate the indicators' status in the Fuel Smart Card Project. The researcher has also provided some suggestions on the successful implementation of E-Government development projects.  相似文献   

Erratum: “Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response” [Biomicrofluidics 15, 021501 (2021)]     

Ecem Saygili  Ece Yildiz-Ozturk  Macauley J. Green  Amir M. Ghaemmaghami  Ozlem Yesil-Celiktas 《Biomicrofluidics》2021,15(3)

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Asia and the future of football: the role of the Asian Football Confederation     

Amir Ben Porat 《Soccer & Society》2017,18(7):1088-1090

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Léon Foucault: His Life, Times and Achievements     

Amir D. Aczel 《Science & Education》2004,13(7-8):675-687

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Current Situation of Molecular Diagnostic Assay in Iran: Is it Necessary to Revise of Health Surveillance System at Laboratory Level?     

Massoud Hajia  Amir Sohrabi 《Indian journal of clinical biochemistry : IJCB》2021,36(2):250

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A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve     

Ying Yi  Amir Zaher  Omar Yassine  Jurgen Kosel  Ian G. Foulds 《Biomicrofluidics》2015,9(5)

Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve''s closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.  相似文献   

Archaeosome: As New Drug Carrier for Delivery of Paclitaxel to Breast Cancer     

Seyed Ebrahim Alavi  Hamidreza Mansouri  Maedeh Koohi Moftakhari Esfahani  Fatemeh Movahedi  Azim Akbarzadeh  Mohsen Chiani 《Indian journal of clinical biochemistry : IJCB》2014,29(2):150-153

In the present study, paclitaxel was archaeosomed to reduce side effects and improve its therapeutic index. Carriers have made a big evolution in treatment of many diseases in recent years. Lipid carriers are of special importance among carriers. Archaeosome is one of the lipid carriers. Paclitaxel is one of the drugs used to treat breast cancer which has some unwanted side effects despite its therapeutic effects. Archaeosomes were extracted from methanogenic archi bacteria and synthesized with a certain ratio of paclitaxel in PBS. The mean diameter of archaeosomal paclitaxel was measured by Zeta sizer instrument, Drug releasing of archaeosomal paclitaxel was examined within 26 h which results showed that the most drug releasing occurs during first 3 h. The cytotoxicity effect of archaeosomal paclitaxel on breast cancer’s cell line was evaluated by MTT assay which results showed that the cytotoxicity effect of archaeosomal paclitaxel on breast cancer’s cell line is more than that of the standard paclitaxel formulation. The results indicated that new drug delivery of paclitaxel using archaeosome, increases the therapeutic index of the drug.  相似文献   

Effect of Sodium Chloride on Efficiency of Cisplatinum Dissolved in Dimethyl Sulfoxide: An In Vitro Study     

Seyed Kazem Bagherpour Doun  Sohrab Halal Khor  Dardi Qujeq  Hasan Ebrahimi Shahmabadi  Seyed Ebrahim Alavi  Fatemeh Movahedi  Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2014,29(2):242-245

Cisplatinum (Cispt) is an anti-cancer drug with a low level of solubility. One of Cispt’s solvents is dimethyl sulfoxide (DMSO) which can be substituted with chlorine of drug as Cispt’s solvent. Applying such a solvent in biological studies is impossible due to intense reduction in activity. On the other hand, it is specified that Cispt’s stability is increased in aqueous media by increasing sodium chloride (NaCl) concentration up to 0.9 %. Consequently, we intended to study the effect of DMSO on cytotoxicity of Cispt in presence of sodium. MTT assay was employed to study cytotoxicity effect of Cispt + NaCl + DMSO and Cispt + DMSO on G-292 cell line. Cytotoxicity in dilutions of 300 and 9 (p < 0.01) of Cispt in Cispt + NaCl + DMSO formulation was equal to 78 and 7 %. These values were estimated 79 and 18 % for Cispt + DMSO formulation and 79 and 24 % for free drug. IC50 values demonstrated reduction of 45 % in cytotoxicity of Cispt in Cispt + DMSO formulation. Studying chemical structure of Cispt and Cispt dissolved in DMSO showed that NaCl cannot inhibit inactivating effect of DMSO on Cispt and effect of this solvent on Cispt is independent from presence of NaCl. Results represented that using NaCl does not result in stability and keeping cytotoxicity properties of Cispt in DMSO. Findings suggest more studies for using DMSO as a solvent of Cispt.  相似文献