BMD and Serum Intact Osteocalcin in Postmenopausal Osteoporosis Women     

Jagtap VR  Ganu JV  Nagane NS 《Indian journal of clinical biochemistry : IJCB》2011,26(1):70-73

India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1) to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy (alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited as control. Mean bone mineral density T score and Z score was significantly decreased (P < 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of BMD—T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels were significantly increased (P < 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P < 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of osteoporosis and for monitoring responses to antiresorptive therapy.  相似文献   

A Review on Salivary Genomics and Proteomics Biomarkers in Oral Cancer     

Franky D. Shah  Rasheedunnisa Begum  Bhairavi N. Vajaria  Kinjal R. Patel  Jayendra B. Patel  Shilin N. Shukla  Prabhudas S. Patel 《Indian journal of clinical biochemistry : IJCB》2011,26(4):326-334

Oral cancer has emerged as an alarming public health problem with increasing incidence and mortality rates all over the world. Therefore, the implementation of newer screening and early detection approaches are of utmost importance which could reduce the morbidity and mortality associated with this disease. Sensitive and specific biomarkers for oral cancer are likely to be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. Unlike other deep cancers, oral cancer is located in oral cavity. Hence, the direct contact between saliva and oral cancer lesion makes the measurement of tumor markers in saliva an attractive alternative to serum and tissue testing. The DNA, RNA and protein molecules derived from the living cancer cells can be conveniently obtained from saliva. Thus, salivary biomarkers, a non-invasive alternative to serum and tissue-based biomarkers may be an effective modality for early diagnosis, prognostication and monitoring post therapy status. In the current post-genomic era, various technologies provide opportunities for high-throughput approaches to genomics and proteomics; which have been used to evaluate altered expressions of gene and protein targets in saliva of oral cancer patients. The emerging field of salivary biomarkers has great potentials to prove its clinical significance to combat oral cancer. Hence, we have reviewed importance of several salivary genomics and proteomics biomarkers for oral cancer.  相似文献   

Are we using Thyroid Function Tests Appropriately?     

Gupta S  Verma M  Gupta AK  Kaur A  Kaur V  Singh K 《Indian journal of clinical biochemistry : IJCB》2011,26(2):178-181

Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples (87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests. 77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7% in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction and order the appropriate test in a rational and cost effective manner.  相似文献   

Application of Sigma Metrics for the Assessment of Quality Assurance in Clinical Biochemistry Laboratory in India: A Pilot Study     

Singh B  Goswami B  Gupta VK  Chawla R  Mallika V 《Indian journal of clinical biochemistry : IJCB》2011,26(2):131-135

Ensuring quality of laboratory services is the need of the hour in the field of health care. Keeping in mind the revolution ushered by six sigma concept in corporate world, health care sector may reap the benefits of the same. Six sigma provides a general methodology to describe performance on sigma scale. We aimed to gauge our laboratory performance by sigma metrics. Internal quality control (QC) data was analyzed retrospectively over a period of 6 months from July 2009 to December 2009. Laboratory mean, standard deviation and coefficient of variation were calculated for all the parameters. Sigma was calculated for both the levels of internal QC. Satisfactory sigma values (>6) were elicited for creatinine, triglycerides, SGOT, CPK-Total and Amylase. Blood urea performed poorly on the sigma scale with sigma <3. The findings of our exercise emphasize the need for detailed evaluation and adoption of ameliorative measures in order to effectuate six sigma standards for all the analytical processes.  相似文献   

Study of resonance-cone propagation in truncated hyperbolic metamaterial grids using transmission-line matrix simulations     

Omar F. Siddiqui  George V. Eleftheriades 《Journal of The Franklin Institute》2011,348(7):1285-1297

In this paper, we utilize transmission-line matrix simulations to study the electromagnetic properties of hyperbolic metamaterial grids, which are synthesized by arranging unloaded transmission lines over electrical ground planes, such that the unit cells are rectangular in shape. The hyperbolic grids support Bragg and Hyperbolic resonant modes that have rectangular and hyperbolic dispersion surfaces, respectively. We demonstrate the formation of these resonant modes in the hyperbolic grids and their refraction, and spatial scanning properties via circuit simulations. The simulation results are compared with experimental results of a two-layer anisotropic hyperbolic metamaterial.  相似文献   

Fear and Loathing in the Fog: The Perceived (and Persistent) Vagaries of Tenure Standards Among Mass Communication Professors     

Thomas Gould 《Publishing Research Quarterly》2011,27(1):36-53

Perhaps nothing strikes more fear into the hearts of all tenure-track professors than the process itself. Are four papers in this journal good enough? Are eight papers in another okay? What if someone doesn’t like me or my area of research? These issues have plagued academia since the first essay was penned by the first researcher hundreds of years ago. While personal bias and journal preference continue to infect honest tenure reviews, solutions exist. This does not mean we have a magic bullet to solve issues of bullying or elitism. However, if we are honest in our desire to improve the Academy, we should avail ourselves of every possible tool for improvement. This essay is based on a survey sent to 2,500 mass communication educators. Of the almost 500 respondents, roughly 10% took the time to express emotions that ranged from fear and confusion to outright rage and anger, all because what ought to be clear is not. The author offers 10 ideas of how academia can improve its evaluation of new faculty, as well as a few suggestions regarding the unnecessary inclusion of personal issues in a process that ought to be about creating better researchers and teachers.  相似文献   

Bill Martin and Xuemei Tian: Books,Bytes and Business: The Promise of Digital Publishing     

Jeff Gomez 《Publishing Research Quarterly》2011,27(1):96-97

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The Rise of Global Publishing and the Fall of the Dream of the Global Book: The Editing of Peter Carey     

Stuart Glover 《Publishing Research Quarterly》2011,27(1):54-61

The article documents the editorial relationship between Peter Carey and his New York based editor for Knopf, Gary Fisketjon, who worked with Carey on his True History of the Kelly Gang. This account provides the basis for a discussion of how globalised publishing, while promising unity—a single text across all territories—has instead introduced a tension into the previously cohesive triad of author, editor, and the single authorized text. As Fisketjon’s experience lays bare, major contemporary texts that are published in multiple editions in different global centers may well proceed through competing or at least parallel editing processes with different presses, different editors, and in different publishing territories. The authorized single edition, even of major literary texts, has been replaced by competing editions. The single edit and editor have been replaced by competing “servant[s] of the writer” (to use Fisketjon’s phrase). Cohesion, while not quite giving way to disunity, gives way to multiplicity and plurality. The experience of the Kelly Gang book is cast against a longer narrative of Carey’s interactions with editors including the University of Queensland Press (UQP) from the 1970s and Faber from the 1980s.  相似文献   

Student Attitudes and Behaviors Towards Digital Textbooks     

Mitchell Weisberg 《Publishing Research Quarterly》2011,27(2):188-196

The purpose of this article is to add to the collective body of knowledge on student behavior and attitudes relative to the adoption of digital textbooks. The article summarizes an ongoing research project that examines past, current and evolving behavior in the classroom related to digital textbooks and school. It includes students, faculty and administrative attitudes behaviors and perceptions. This research was undertaken at the Sawyer Business School of Suffolk University in Boston, Massachusetts. Student attitudes and behavior toward their use of digital textbooks (eTextbooks) in higher education was examined in an ongoing longitudinal study over two years at Sawyer Business School, Suffolk University. Students in the class were divided into six teams. Five of the teams were assigned an eTextbook device and the sixth team was given a paper textbook for use through the semester. The digital technologies examined were: Amazon Kindle, Sony eReader Touch, Apple iPad, enTourage eDGe, and CourseSmart. Student attitudes and behaviors were examined pre and post class by survey each semester, and during the semesters through quizzes, journals and classroom discussion. Differential learning was measured between the six teams. Student attitudes and behaviors are becoming more receptive to and accepting of using digital textbooks each year. There was no significant difference in learning between the eTextbook devices teams or between them and the paper textbook team.  相似文献   

One World Publishing,Brought to You by the Internet     

Joseph J. Esposito 《Publishing Research Quarterly》2011,27(1):13-18

The migration from print books to ebooks is more than a change of format; it is also the first step in an ongoing process, whose final outcome is hard to predict. Ebooks are likely to lead to a restructuring of the industry by enabling cross-border commerce. This in turn is likely to lead to difficult disputes over territorial rights. It appears probable that these disputes will be resolved by an assertion of the dominance of the American market and the publishers that already serve it well, as authors are likely to place their rights with practitioners in the largest markets. This in turn will lead to the acquisition of many smaller “national” publishers, which cannot compete on a world stage with truly global publishers. But rather than simply becoming sources of editorial product for American-based global marketing machines, smaller publishers operating in different regions will respond through innovation, both in product design (attempting to do electronically what cannot be done in print) and in developing new marketing plans that the giant publishers would be indisposed to pursue.  相似文献