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Nilesh Chandra Mohit Mehndiratta B. D. Banerjee K. Guleria A. K. Tripathi 《Indian journal of clinical biochemistry : IJCB》2016,31(1):30-37
Oxidative stress has been proposed as one of the causes involved in idiopathic fetal growth restriction (IFGR). However, the exact relationship between oxidative stress and IFGR is not understood. This study aimed at understanding the role of oxidative stress and antioxidant status in IFGR materno-fetal dyads and matched controls. 75 materno-fetal dyads with IFGR were enrolled with equal number of normal low risk controls. Malondialdehyde (MDA) levels were measured as marker of oxidative stress, while paraoxonase-1 (PON1) activity and total antioxidant capacity (TAC) of serum were measured as markers of antioxidant status. MDA levels were increased in both maternal and cord blood of IFGR neonates as compared to controls (p < 0.001). TAC of serum were found to be decreased in IFGR (both maternal and cord blood) as compared to controls (p < 0.001; p < 0.05, respectively). PON1 activity was found to be decreased in the IFGR mothers while it was found increased in IFGR cord blood (p < 0.01; p < 0.001)). IFGR is a state of increased oxidative stress. Decreased PON1 enzymatic activity in mothers is also associated with IFGR. 相似文献
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Ranjana Singh Rajesh K. Singh Anil K. Tripathi Nikhil Gupta Ajai Kumar Anil K. Singh Abbas A. Mahdi Rajendra Prasad Raj K. Singh 《Indian journal of clinical biochemistry : IJCB》2004,19(1):14-20
The circadian periodicity of plasma lipid peroxide levels and activities of superoxide dismutase (SOD), catalase (CAT) and
glutathione peroxidase (GPx) were studied in 50 clinically, bacteriologically and radiologically proven fresh cases of pulmonary
tuberculosis (age: 21–45 years) and 60 age-matched healthy volunteers with diurnal activity from 06∶00 to about 22∶00 and
nocturnal rest. A marked circadian variation in plasma lipid peroxide level was recorded in healthy subjects and pulmonary
tuberculosis patients with significant amplitude and acrophase around 16∶21 and 17∶12 respectively. The acrophase tended to
be delayed in tuberculosis patients. Furthermore, a statistically significant circadian rhythm was found in SOD, CAT and GPx
activities in normal volunteers and pulmonary tuberculopsis patients. SOD and CAT enzyme activity was noted to be maximum
at 06∶00 and minimum at 00∶00 in tuberculosis patients. The circadian acrophase for GPx activity was recorded at 16∶15 in
normals and around 22∶45 in patients. Moreover, the activity was found to be decreased at all sampling hours during 24-hours
sleep-awake period in patients in comparison to healthy counterparts. The MESOR and circadian amplitude also decreased markedly.
The decreased activity of measured antioxidant enzymes in pulmonary tuberculosis patients could probably be associated with
oxidative stress and/or decreased anti-oxidant defensive mechanism in such patients. 相似文献
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Manorama Tripathi 《International Information and Library Review》2013,45(3-4):194-202
The paper defines and explains e-governance. It also discusses an e-governance initiative Lokvani (which means voice of the masses) which has been taken in the small district of Sitapur; it is located in Uttar Pradesh, northern part of India. Highlights the upsides and downsides of Lokvani. This paper also dwells upon the challenges which must be overcome before implementing e-governance projects across the length and breadth of the country. It offers suggestions for successfully implementing e-governance in the country. 相似文献
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Edgar F. Pierce Norris W. Eastman Hem T. Tripathi Kirsten G. Olson William L. Dewey 《Journal of sports sciences》2013,31(6):499-502
Previous research investigating the response of plasma ß‐endorphins (ß‐EP) to resistance exercise has resulted in equivocal findings. To further examine the effects of resistance exercise on ß‐endorphin immunoreactivity, six resistance‐trained athletes participated in a three‐set series of eight repetitions of isotonic exercise. All exercises were performed at 80% maximal effort. Blood was sampled from the group by venepuncture, both prior to and following the exercise bout, and ß‐endorphin concentration was determined by radioimmunoassay. The results indicated that mean ( ± S.E.) plasma levels of ß‐endorphins following exercise (18.04 ± 3.4 pg ß‐EP ml‐1) were not significantly changed from pre‐exercise (control) levels (19.59 ± 2.4 pg ß‐EP ml‐1), although there was considerable inter‐individual variability. Our results support previous research which has reported no significant changes in ß‐endorphin immunoreactivity following resistance exercise, as well as reported findings of considerable variability in the ß‐endorphin response to exercise. 相似文献
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Rachna Agarwal Suman S. Kushwaha C. B. Tripathi Neeraj Singh Neelam Chhillar 《Indian journal of clinical biochemistry : IJCB》2008,23(4):369-374
Alzheimer’s disease is the most common form of dementia in the elderly and it’s prevalence is rapidly rising. Oxidative stress
plays important role in the pathophysiology of Alzheimer’s disease. Metals like copper, iron derived through diet can act
as pro-oxidant under oxidative stress. In the present study, serum copper levels were evaluated in 50 patients with Alzheimer’s
disease, 24 patients with Vascular Dementia and 30 controls. All the groups were also investigated for serum ceruloplsmin
levels. The mean copper levels in Alzheimer’s disease and Vascular Dementia were significantly raised compared to controls.
An attempt has been made to study the relationship of serum copper with ceruloplasmin. Our study found weak correlation between
copper and ceruloplasmin levels in Alzheimer’s disease and Vascular Dementia. 相似文献
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The paper defines and explains e-governance. It also discusses an e-governance initiative Lokvani (which means voice of the masses) which has been taken in the small district of Sitapur; it is located in Uttar Pradesh, northern part of India. Highlights the upsides and downsides of Lokvani. This paper also dwells upon the challenges which must be overcome before implementing e-governance projects across the length and breadth of the country. It offers suggestions for successfully implementing e-governance in the country. 相似文献
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Devika Tayal Binita Goswami S. K. Patra Reva Tripathi Alka Khaneja 《Indian journal of clinical biochemistry : IJCB》2014,29(2):139-144
Preeclampsia is a multisystem disorder associated with maternal hypertension, placental abnormalities and adverse fetal outcomes. The various pathways involved in its etiology include endothelial dysfunction, inflammatory milieu, lipid peroxidation and immunological imbalance. The present study was conducted to evaluate the causative and predictive role of nitric oxide, lipid peroxidation end products (MDA) and inflammatory cytokines (IL-6, TNF-α) in clinical presentation, severity and fetal outcome in preeclampsia. The study population was divided into 3 groups- Non- pregnant females comprising the control population; G1 and G2 groups included normal pregnant and pregnant females with preeclampsia with 50 patients in each group. Nitric Oxide and MDA levels were found to be highest in the preeclamptic patients as compared to other two groups. ROC curve analysis shows the superiority of the inflammatory markers as determinants of severity of preeclampsia which suggests the emerging role of pro inflammatory markers in the various pathological changes in preeclampsia. TNF-α emerged as the best marker in multivariate analysis and thus, has the potential for being used as a marker for PIH. Our study illustrates the multifactorial etiology of preeclampsia involving oxidative stress, proinflammatory milieu and endothelial dysfunction. 相似文献
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In this paper, emphasis has been put on providing the result of a detailed simulation study on the dynamics and efficiency of a vector-controlled voltage source inverter (VSI)-fed surface-mounted permanent magnet synchronous motor (SPMSM) drive; which employs firstly a model-based loss-minimization algorithm (MLMA) and secondly a binary search-based online loss-minimization algorithm (BSOLMA), so as to reduce the total controllable electrical losses without much affecting the dynamic performance of the drive. The steady-state SPMSM model taking into account the core loss has been considered. The dynamic performances of the SPMSM drive employing individually the abovementioned loss minimization algorithms (LMAs) have been compared with that employing conventional zero d-axis current control (ZDCC) through extensive digital computer simulations. The simulation results show that efficiency of the drive enhances with the employment of the LMA. 相似文献