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1.
Unstable angina is a critical condition of heart resulting from narrowing of vessels supplying blood to heart. Ischemia of
the myocardium leads to oxidative stress and severe tissue damage. The objective of the present study was to determine the
effect of l-arginine administration on the oxidant–antioxidant homeostasis which otherwise gets imbalanced in patients with cardiovascular
diseases. The results obtained, show improvement in the oxidant–antioxidant levels of the subjects upon incorporation of l-arginine. Our findings suggest that supplementation of l-arginine along with regular anti-anginal therapy may be beneficial to the patients of unstable angina. 相似文献
2.
Serum total cholesterol and triglyceride levels were estimated in 45 dilated cardiomyopathy (DCM) patients and were compared
with 31 healthy controls. The total serum cholesterol (215±50 mg/dl) and serum triglyceride (162±76 mg/dl) levels in DCM patients
did not show any significant changes as compared to normal controls. The cholesterol and triglyceride and the individual lipoprotein
fractions, viz HDL, VLDL, LDL and chylomicrons were analysed in 10 patients. The values did not differ significantly when
compared to those of controls. These findings suggest that serum lipids may not play a role in the antietiopathogenesis of
DCM. 相似文献
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This study provides an overview of the research output of Jawaharlal Nehru University, New Delhi, India, in terms of number of publications contributed by faculty members and researchers. The study analyzes bibliometric indicators of published research of Jawaharlal Nehru University as indexed in the Web of Science. There were 5,007 research publications from Jawaharlal Nehru University in the four decades from 1971–2010 (70s; 80s; 90s; and 2000s). The study noted encouraging trends in collaborative research work with multiple-authored research papers. International collaboration in research was also observed among the faculty members and researchers. English was the predominant language of communication. The social scientists and humanists of Jawaharlal Nehru University publish books which are not indexed in the Web of Science. Similarly, research work published in regional languages or published in national level journals are seldom included in the Web of Science. It suggests that research needs to be done by collecting data from the Indian Citation Index and books published by the researchers in order to get an accurate and consolidated picture of the research output of the university. 相似文献
5.
Online open source software platforms, such as Sourceforge.net, play a vital role in creating an ecosystem that enables the creation and growth of open source projects. However, there is little research exploring the interactions between open source stakeholders and the platform. We believe that the sustainability of the platform crucially depends on financial incentives. While platforms can obtain these incentives through multiple means, in this paper we focus on one form of financial incentives—voluntary monetary donations by open source community members. We report findings from two empirical studies that examine factors that impact donations. Study 1 investigates the factors that cause some community members to donate and not others. We find that the decision to donate is impacted by relational commitment with open source software platform, donation to projects and accepting donations from others. Study 2 examines what drives the level of donation. We find that the length of association with the platform and relational commitment affects donation levels. 相似文献
6.
Rohit Kumar Gupta Sagar Jayantilal Dholariya Smita Kaushik S. K. Gupta Reva Tripathi Shyam Lata Jain 《Indian journal of clinical biochemistry : IJCB》2021,36(2):221
Ovarian cancer has been emerged as a most common and lethal gynecological malignancy in India. High serum insulin and low adiponectin have been associated with increased risk of ovarian cancer. But their role in development of ovarian cancer is conflicting and little evidence is available. We aimed to evaluate blood levels of insulin and adiponectin in epithelial ovarian cancer (EOC) patients and their association with the risk to develop EOC. The study included following three groups; Group 1: fifty cases of cytohistopathologically confirmed cases of EOC, Group 2: fifty age matched cases of benign ovarian conditions and Group 3: fifty ages matched healthy controls with no evidence of any benign or malignant ovarian pathology as ruled out by clinical examination and relevant investigations. Cytohistopathologically confirmed and newly diagnosed cases of EOC and benign ovarian cancer were included in this study. The median value of fasting serum insulin was significantly high (15.0 µlU/ml, P = 0.02) and adiponectin were significantly low (5.1 µg/ml, P < 0.001) in ovarian cancer patients compared to benign ovarian tumors and healthy controls group. A significant increase risk of ovarian cancer was found in high tertile (≥ 18.7 µlU/ml) of serum insulin level (OR = 2.7; 95% CI = 1.00–6.67, P = 0.04) and lower tertile (≤ 5.45 µg/ml) of adiponectin level (OR = 3.2; 95% CI = 1.10–9.71, P = 0.03). High serum insulin level and low adiponectin levels were significantly associated with increased risk for development of ovarian cancer. 相似文献
7.
The purpose of this paper is to provide a reconnaissance of major academic libraries located in Australia, Canada, the U.K. and U.S.A. that have embraced Web 2.0 tools for enhancing library services. The research is based on a survey of websites of 277 university libraries. The checkpoints used for this evaluative study were given by Nguyen (2008) for evaluating various Web 2.0 tools. Additional checkpoints were arrived at after visiting and browsing the various sites. The findings of the study acknowledge the strength of Web 2.0 tools in improving library services for users. Really Simple Syndication (RSS), Instant Messaging (IM) and blogs are popular in academic libraries. The paper concludes by offering best practices for implementing Web 2.0 tools in academic libraries. 相似文献
8.
While advances in genomics have enabled sensitive and highly parallel detection of nucleic acid targets, the isolation and extraction of the nucleic acids remain a critical bottleneck in the workflow. We present here a simple 3D printed microfluidic chip that allows for the vortex and centrifugation free extraction of nucleic acids. This novel microfluidic chip utilizes the presence of a water and oil interface to filter out the lysate contaminants. The pure nucleic acids, while bound on cellulose particles, are magnetically moved across the oil layer. We demonstrated efficient and rapid extraction of spiked Human Papillomavirus (HPV) 18 plasmids in specimen transport medium, in under 15 min. An overall extraction efficiency of 61% is observed across a range of HPV plasmid concentrations (5 × 101 to 5 × 106 copies/100 μl). The magnetic, interfacial, and viscous drag forces inside the microgeometries of the chip are modeled. We have also developed a kinetics model for the adsorption of nucleic acids on cellulose functionalized superparamagnetic beads. We also clarify here the role of carrier nucleic acids in the adsorption and isolation of nucleic acids. Based on the various mechanistic insights detailed here, customized microfluidic devices can be designed to meet the range of current and emerging point of care diagnostics needs. 相似文献
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The open source software (OSS) movement thrives on innovation and volunteer effort of developers. Scholars have expressed widespread concern about the sustainability of the OSS movement due to high levels of volunteerism. In this paper, we address a central challenge to the sustainability of OSS-developers’ acceptance of monetary rewards. We strive to explain why some OSS developers accept monetary rewards and others do not. Viewed through the theoretical lens of the private-collective innovation model (0395 and 0400), this allows us to describe when developers will accept private financial rewards. Our main research objective is to clearly map the web of relationships between causal antecedents, and developers’ acceptance behavior. Using a unique dataset that combines survey and behavioral measures, we find that – (a) intention to accept monetary rewards mediates the impact of motivational elements on developers’ acceptance of monetary rewards; (b) intrinsic and extrinsic motivations positively affect their intention to accept monetary rewards, community motivation negatively impacts intention and ideological motivation does not affect the intention to accept rewards and (c) these effects are obtained even after inclusion of several control variables. The theoretical and managerial implications of our work are described. 相似文献
10.
Liang-Wen Liao Po-Hsuan Chen Shu-Yi Tsai Adarsh Tripathi Akhil K. Paulose Shing-Jyh Chang Yu-Lin Wang 《Biomicrofluidics》2021,15(2)
In this experimental study, a portable biosensor was developed to detect β-human chorionic gonadotropin (β-hCG), which is extensively used in pregnancy tests and serves as a biomarker for ectopic pregnancy. The sensor used is an electric-double-layer field-effect transistor biosensor with the extended-gate design. Bias voltage is applied on the sensor to measure the resulting drain current signals. Gold electrode surface is functionally activated with an anti-β-hCG antibody to capture β-hCG protein. Fluorescence imaging technique is utilized to confirm the surface functionalization. The biosensor demonstrates a dynamically wide range of molecules as detection targets at very low sample concentrations, which shows the potential to detect ectopic pregnancy in very early stages and easily keep track of its periodic changes. It can be produced en masse and does not use additional labels/reagents or pre-processing techniques for the sample. This biosensor can significantly reduce the manufacturing costs and is comparable with the currently available commercial ß-hCG assays. It is suitable for early diagnosis of ectopic pregnancy with low cost and easy operation at home with urine samples. 相似文献