Serum Lipid Alterations in Early Rheumatoid Arthritis Patients on Disease Modifying Anti Rheumatoid Therapy     

Sana Parveen  Rachel Jacob  Liza Rajasekhar  C. Srinivasa  Iyyapu Krishna Mohan 《Indian journal of clinical biochemistry : IJCB》2017,32(1):26-32

Dyslipidaemia is a major CVD risk factor in the general population. Current evidence suggests that lipid metabolism is altered in RA due to inflammation, and that use of anti-inflammatory therapy may reverse some of these changes. The objective of our study is to compare the effect of treatment with DMARD on lipid fractions after 6 months of therapy. Forty patients who met the American College of Rheumatology, ACR/EULAR criteria for rheumatoid arthritis, with disease duration of less than 1 year and no prior treatment were included in the study. Thirty healthy volunteers were included as controls. The mean DAS-28 at disease onset was 5.15 ± 1.3. Early Rheumatoid Arthritis (ERA) patients exhibited higher serum levels of total cholesterol (TC) and lowdensity lipoprotein cholesterol (LDL-C) and lower serum high-density lipoprotein cholesterol (HDL-C) levels compared to controls. As a consequence, the atherogenic index of plasma [log (TG/HDL-C)], the atherogenic indices: TC/HDL-C as well as LDLC/HDL-C was significantly higher in ERA patients compared to controls. After 6 months of treatment, there was significant reduction of the DAS 28, HDL-C and Apo A-I improved and Lp(a) decreased significantly. All lipid ratios improved, a phenomenon primarily due to the increase in serum HDL-C levels. These changes were inversely correlated with CRP and ESR. In conclusion, ERA patients are characterized by an atherogenic lipid profile, which improves with DMARD therapy.  相似文献   

Large scale development of learning materials: Critical issues     

Krishna Kumar Bhardwaj  Prabish Chandran  A. F. O'Neal  Andrew S. Gibbons 《Educational technology research and development : ETR & D》1998,46(2):101-110

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Schemas and mental models in geometry problem solving     

Mohan Chinnappan 《Educational Studies in Mathematics》1998,36(3):201-217

Recent investigations of mathematical problem solving have focused on an issue that concerns students' ability at accessing and making flexible use of previously learnt knowledge. I report here a study that takes up this issue by examining potential links between mental models constructed by students, the organisational quality of students' prior geometric knowledge, and the use of that knowledge during problem solving. Structural analysis of the results suggest that the quality of geometric knowledge that students develop could have a powerful effect on their mental models and subsequent use of that knowledge.  相似文献   

浅析在高校中建立科研质量管理体系的意义、方法及需要注意的问题   总被引：2，自引：0，他引：2  

张君  邱建国  杨默函 《科技管理研究》2010,(17)

通过分析高校科研质量管理体系建立的背景和意义,结合高校科研质量管理体系建设的实践经验,重点阐述高校建立科研质量体系的方法和步骤,提出了体系建立需要注意的问题并给出了相应对策.  相似文献   

On the inadequacy of Hertzian solution of two-dimensional line contact problems     

Krishna P. Singh 《Journal of The Franklin Institute》1974,298(2):139-141

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学术金字塔中的“她力量”：高校工科 女性教师科研自我效能感研究          下载免费PDF全文

朱佳妮  周默涵 《复旦教育论坛》2022,20(5):72-79

高校女性教师是科技人才队伍的重要组成部分，是我国科技事业十分重要的力量，然而这一群体仍面临着人数较少、职业发展遭遇瓶颈、生育友好型环境有待提升等困境。研究基于科研自我效能感理论，运用混合研究方法，对上海6所高校204位工科女性教师开展问卷调查，并辅之以质性访谈，探索工科女性教师科研自我效能感现状及其影响因素。研究发现：工科女性教师的科研概念化能力、执行和汇报能力自我效能感水平相对较高；日均照顾子女和长辈的时间、对自身的领导能力和担任领导职位的自信程度等因素均对其科研自我效能感产生显著正向影响。基于上述结果，研究从国家和高校两个层面对工科女性教师人才的支持政策提出建议。  相似文献   

用主成分分析法和聚类分析法确定AA肉鸡生产指标     

马发顺  牛月琳  邢安琪  赵梦雪  王莫含  元雪浈  梁秀丽 《安阳工学院学报》2022,21(4):104-108

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