Patients could lose out in tussle over gene bank     

Patel T 《New scientist (1971)》1994,141(1918):9

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Thyroidal regulation of substrate kinetics properties of cytochrome oxidase in rat liver mitochondria     

Hiren R. Modi  Surendra S. Katyare  Samir P. Patel 《Indian journal of clinical biochemistry : IJCB》2008,23(3):272-278

Effects of thyroidectomy (T_x) and subsequent treatment with 3,5,3’-triiodothyronine (T₃), and combined treatment (T_R) with T₃ + thyroxine (T₄) on substrate kinetics properties of cytochrome oxidase of rat liver mitochondria were examined. T_x resulted in lowering of cytochromes content with decrease in the enzyme activity, and K_m and V_max. T₃ and T_R regimens restored the cytochromes contents and the V_max values to normal. In control, T₃ and T_R groups the enzyme activity resolved in two kinetic components; in T_x group three kinetic components were evident. The K_m values for all components decreased significantly in the experimental groups with concomitant increase in catalytic efficiency, K_cat/K_m. Significant alterations in the contents of total phospholipid and of cholesterol were noted while the changes in the phospholipids composition were only of restricted nature. Regression analysis revealed that total phospholipid, cholesterol and phosphatidylcholine, phosphatidylethanolamine play significant role in fine tuning the enzyme activity.  相似文献   

An Investigation of Counselor Educators' Attitudes Toward Evidence‐Based Practices     

Samir Patel  W. Bryce Hagedorn  Haiyan Bai 《Counselor Education & Supervision》2013,52(2):96-108

Evidence‐based practices (EBPs) receive little attention in counselor education curricula despite the ethical obligation for counselor educators to teach EBPs to counseling students. This study investigates counselor educators’ attitudes toward EBPs along with perceived barriers to the inclusion of EBPs in counselor education curricula.  相似文献   

Notable and Emerging Variants of SARS-CoV-2 Virus: A Quick Glance     

Sagar Dholariya  Deepak Narayan Parchwani  Ragini Singh  Amit Sonagra  Anita Motiani  Digishaben Patel 《Indian journal of clinical biochemistry : IJCB》2021,36(4):451

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), is a highly contagious pathogenic coronavirus to emerge and spread in human populations. Although substantial exertions have been laid to avert spread of COVID-19 by therapeutic and preventive countermeasures, but emergence of SARS-CoV-2 variants as a result of mutations make the infection more ominous. New viral confers a higher nasopharyngeal viral load, increased viral transmissibility, higher infectiousness, immune escape, increased resistance to monoclonal/polyclonal antibodies from convalescence sera/vaccine, and an enhanced virulence. Thus, it is pertinent to monitor evolving mutations and genetic diversity of SARS-CoV-2 as it is decisive for understanding the viral variants. In this review we provide an overview of colloquial nomenclature and the genetic characteristics of different SARS-CoV-2 variants in the context of mutational changes of the circulating strains, transmissibility potential, virulence and infectivity.  相似文献   

Sickle Cell Trait Presenting as Chronic Calcific Pancreatitis with Pseudocyst- A Case Report     

Seema Shah  Sunil Jondhale  Rachita Nanda  Suprava Patel  Eli Mohapatra  Anil Kumar Goel 《Indian journal of clinical biochemistry : IJCB》2021,36(2):239

Sickle cell disease is known to cause acute pancreatitis either due to gall stones obstructing the pancreatic duct or by vaso-occlusive mechanism. However chronic pancreatitis is a very rare complication in sickle cell anemia. We report a case of sickle cell trait presenting with chronic pancreatitis with pseudo cyst. USG abdomen and CT abdomen confirmed the diagnosis of chronic calcific pancreatitis with pseudocyst. Etiological work up for other causes did not reveal anything except sickle cell trait. This case represents a rare association between chronic calcific pancreatitis and sickle cell trait.  相似文献   

A report on clinical importance of serum glycoconjugates in oral cancer     

Bina R. Baxi  Prabhudas S. Patel  Siddharth G. Adhvaryu 《Indian journal of clinical biochemistry : IJCB》1990,5(2):139-144

For evolving a potential Biochemical index for early diagnosis of oral cancer, serum levels of total sialic acid (TSA), lipid bound sialic acid (LSA), mucoid proteins and hexoses (galactose and mannose) were determined in 30 patients with oral cancer. The results were compared with similar values obtained for 30 patients with oral precancerous conditions, 24 healthy controls and 15 normal individuals with a habit of tobacco chewing. All the biomarkers were significantly elevated in oral cancer patients compared to the controls, the normal chewers and precancer patients. The levels of glycoconjugates showed significant increase in patients with oral precancerous conditions compared to the controls. Only LSA and hexoses showed significantly elevated levels in oral precancer patients compared to the normal chewers. The levels of glycoconjugates were more or less comparable between normal chewers and the controls. The parameters evaluated in the oral cancer patients also showed a progressive rise with the clinical stage of the malignant disease. The levels of the four glycoconjugates were also higher in patients with metastasis compared to those with only primary disease. The present findings suggest that the glycoconjugates have clinical utility in diagnosis of the patients with cancer of the oral cavity as well as in staging the disease.  相似文献   

A comparative study of reactive oxygen species (ROS) related parameters in rat tissues     

Samir P. Patel  Surendra S. Katyare 《Indian journal of clinical biochemistry : IJCB》2006,21(1):48-53

Reactive oxygen species (ROS) are believed to be responsible for pathogenesis of various diseases affecting tissues and systems. ROS generated by mitochondrial electron transport chain as well as extra-mitochondrially are eliminated by the respective defense mechanisms. We checked the activity of ROS generating system such as xanthine oxidase and also the parameter of ROS defense mechanism e.g. superoxide dismutase (SOD), catalase, glutathione peroxidase (GPox), reduced glutathione content (GSH) and glucose-6-phosphate dehydrogenase (G6PDH) in mitochondrial and post-mitochondrial fractions from various tissues (liver, kidney, brain and heart) of normal rats. Extent of lipid peroxidation (LPO) which is immediate consequence of ROS generation was also examined. Our results shows that significant tissue-specific differences exist in mitochondrial and cytosolic ROS generating systems and ROS defense mechanisms.  相似文献   

Evaporation-based microfluidic production of oil-free cell-containing hydrogel particles     

Rong Fan  Kubra Naqvi  Krishna Patel  Jun Sun  Jiandi Wan 《Biomicrofluidics》2015,9(5)

We demonstrate an evaporation-based microfluidic strategy to produce oil-free cell containing hydrogel particles. Perfluoro-n-pentane, which is used as the continuous oil phase to generate cell-containing hydrogel (Extracel) particles, is removed at an elevated temperature. Human colon cancer cells (HCT116) encapsulated in the hydrogel particles show higher viability than cells encapsulated in particles that are produced via a non-evaporative oil phase. In addition, single HCT116 cells can be cultured for a week in such particles and respond to inflammatory stimuli, highlighting the potential applications of the developed strategy for 3D cell culture, drug testing, and cell-based drug delivery.  相似文献   

From Comprehensive to Singular: A Latent Class Analysis of College Teaching Practices     

Corbin M. Campbell  Alberto F. Cabrera  Jessica Ostrow Michel  Shikha Patel 《Research in higher education》2017,58(6):581-604

While decades of research on college teaching has investigated several forms of classroom practices, much of this research approaches teaching as falling into mutually exclusive paradigms (e.g., active learning vs. lecturing). This paper enters inside the college classroom using external raters to understand patterns of pedagogical practices embedded in heterogeneous groups of courses. The study used quantitative observation and draws on data from a multi-institutional study of 587 courses across nine institutions to understand the patterns of teaching practices within courses. Latent class analyses demonstrated that there were five patterns of seven course practices that cluster around active learning, lecturing, and cognitively responsive practices: Comprehensive, Traditional Lecture, Active Lecture, Integrative Discussion, and Active Only.  相似文献   

The Achievement Gap Among Newcomer Immigrant Adolescents: Life Stressors Hinder Latina/o Academic Success     

Sita G. Patel  Alinne Z. Barrera  Michael J. Strambler  Ricardo F. Muñoz  Erynn Macciomei 《Journal of Latinos & Education》2016,15(2):121-133

This study compares life stressors and school outcomes among newcomer immigrant adolescents from Latin America, Asia, and the Caribbean. Participants attended a predominantly low-income, urban international public high school in the northeast. The Latina/o students were exposed to more life stressors and had lower attendance and achievement than non-Latina/o students. Life stressors mediated the relationship between ethnicity and academic outcomes. Results deepen experts’ understanding of the achievement gap, suggesting that newcomer immigrant adolescents from Latin America face unique risks and deserve intervention efforts focused on sociocontextual stressors that may prevent these students from achieving their full academic potential.  相似文献