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51.
We have studied the expression of lactate dehydrogenase and its isoforms in gall bladder cancer, cholelithiasis and chronic cholecystitis. Quantitative and qualitative assays of lactate dehydrogenase and its various isoforms were carried out in the blood sera of patients and healthy controls along with parallel estimation of various liver function test enzymes. Statistical analysis was done using the software Graph Pad Prism. Significantly high expression of lactate dehydrogenase along with alkaline phosphatase and total bilirubin (P ≤ 0.05) was observed in all the three clinical conditions as compared to controls. LDH showed an increasing trend from stage I to stage IV of GBC indicating a significant positive association with the disease progression. The levels of LDH 3 and 4 isoforms appeared significantly more elevated in GBC than cholelithiasis or chronic cholecystitis. We suggest that a careful estimation of total LDH and its isoforms 3 and 4 alone or along with alkaline phosphatase and total bilirubin during different clinical stages, like chronic cholecystitis, cholelithiasis and GBC, may prove to be a potentially useful biomarker in the prognostic management of gall bladder diseases, specifically GBC.  相似文献   
52.
Comparisons of cognitive processing in monolinguals and bilinguals have revealed a bilingual advantage in inhibitory control. Recent studies have demonstrated advantages associated with exposure to two languages in infancy. However, the domain specificity and scope of the infant bilingual advantage in infancy remains unclear. In the present study, 114 monolingual and bilingual infants were compared in a very basic task of information processing—visual habituation—at 6 months of age. Bilingual infants demonstrated greater efficiency in stimulus encoding as well as in improved recognition memory for familiar stimuli as compared to monolinguals. Findings reveal a generalized cognitive advantage in bilingual infants that is broad in scope, early to emerge, and not specific to language.  相似文献   
53.
State departments of education can play an important role in preparing teachers for effectively teaching diverse learners in our schools through state policies and standards on teacher certification and teacher education program accreditation. We conducted a content analysis of state standards on teacher certification and program accreditation in the 50 states and the District of Columbia to understand the type and characteristics of diversity-related requirements. We found that while all states addressed diversity in their standards, the type and characteristics of requirements varied across the states. The diversity requirements are ambiguous in most states, and only a small number of states utilize a “social reconstructionist” approach that focuses on preparing teachers to identify social inequality and take an active role to achieve educational and social equity.  相似文献   
54.
Drawing from the structurational theory of identification [Scott, Corman, & Cheney, 1998] and resilience theory [Buzzanell, 2010], our inquiry provides insight into the sustainability of disaster-relief worker involvement and the discursive processes whereby workers overcome emotional and physical challenges to create resilience labor. Analyzing 23 semi-structured interviews with disaster-relief workers of a non-profit organization, we define resilience labor as the dual-layered process of reintegrating transformative identities and identifications to sustain and construct ongoing organizational involvement and resilience. The identification frames align with familial, ideological, and destruction–renewal network ties that empower individuals to construct their identities in transformative ways. The frames can guide non-profit managers and volunteers working in extreme contexts characterized by societal conflicts or disruption to sustain themselves as they construct resilience labor.  相似文献   
55.
ABSTRACT

Local TV news stations regularly post to social media, on Facebook in particular, in an effort to engage audiences, but little is known about the effect of this practice on newscast ratings. We examine the relationship between engagement on Facebook and newscast ratings using data from Shareablee and Nielsen respectively in regression analyses. We find that Facebook engagement does not cannibalize TV ratings, rather there is a clear positive relationship between the two. However, further analyses suggest that this relationship may be driven by interest in news events or other market-wide factors that result in both Facebook engagement and viewership increasing or decreasing simultaneously.  相似文献   
56.
This article highlights an emerging field known as synthetic biology that envisions integrating designed circuits into living organisms in order to instruct them to make logical decisions based on the prevailing intracellular and extracellular conditions and produce a reliable behavior. The attempt is to design cells capable of sensing a bioweapon or an environmental pollutant, activate its degradation pathway and perform bioremediation or carry out programmed cell death or synthesize complex biomaterials. Within the living cell, a complex interplay of networks formed by genes and proteins mediate all cellular processes. The networks in a system can be dissected into small regulatory gene circuit modules. Synthetic biology attempts to construct and assemble such modules step by step, plug the modules together and modify them, in order to generate a desired behavior. The review gives an insight into the creation of gene circuits and discusses the potential applications in the field of biotechnology, medicine and environmental sciences. Garima Agarwal is a research student in the Molecular Biophysics Unit, Indian Institute of Science. Her areas of research interest include structural biology, bioinformatics and systems biology.  相似文献   
57.
Quality in laboratory has huge impact on diagnosis and patient management as 80–90% of all diagnosis is made on the basis of laboratory tests. Monitoring of quality indicators covering the critical areas of pre-analytical, analytical and post-analytical phases like sample misidentification, sample rejection, random and systemic errors, critical value reporting and TATs have a significant impact on performance of laboratory. This study was conducted in diagnostic laboratories receiving approximately 42,562 samples for clinical chemistry, hematology and serology. The list of quality indicators was developed for the steps of total testing process for which errors are frequent and improvements are possible. The trend was observed for all the QI before and after sensitisation of the staff over the period of 12 months. Incomplete test requisition form received in the lab was the most poor quality indicator observed (7.89%), followed by sample rejection rate (4.91%). Most significant improvement was found in pre- and post-analytical phase after sensitisation of staff but did not have much impact on analytical phase. Use of quality indicators to assess and monitor the quality system of the clinical laboratory services is extremely valuable tool in keeping the total testing process under control in a systematic and transparent way.  相似文献   
58.
Higher Education in India: Growth, Concerns and Change Agenda   总被引:3,自引:0,他引:3  
Higher education in India has grown large since the country's independence in 1947. Starting from a small base, the pace of growth was initially rapid. Initially, the pace of growth was rapid. Enrolments grew by 13 to 14 per cent per annum during the 1950s and 1960s. Over the past few decades, the growth rate has declined noticeably. Since then it has remained stable between 4 and 5 per cent. The nature of growth over the past two decades is, however, strikingly different from the growth in the previous period. This article maps the growth pattern of higher education in India with particular focus on enrolment growth and change in funding patterns. On analysis of the trends, it identifies the concerns and builds a case for change in Indian higher education so that the country's virtuous cycle of economic growth fuelled mainly by its large pool of qualified manpower is sustained.  相似文献   
59.
Schools play a privileged and strategic role in the lives of children acting as their principle environment away from home. Additionally, schools act as part of the community linking families and neighborhoods. These characteristics make schools a relevant setting for mental health service delivery and support to children and parents. In this article the role of the school environment on the development of childhood depression and as a leverage point in the prevention and treatment of depression will be discussed. Rationales for this viewpoint, as well as practical suggestions for reducing the deleterious effects of schooling on children's emotional well‐being, are offered. © 2009 Wiley Periodicals, Inc.  相似文献   
60.
In practice, it is almost impossible to directly add a controller on each node in a complex dynamical network due to the high control cost and the difficulty of practical implementation, especially for large-scale networks. In order to address this issue, a pinning control strategy is introduced as a feasible alternative. The objective of this paper is first to recall some recent advancements in global pinning synchronization of complex networks with general communication topologies. A systematic review is presented thoroughly from the following aspects, including modeling, network topologies, control methodologies, theoretical analysis methods, and pinned node selection and localization schemes (pinning strategies). Fully distributed adaptive laws are proposed subsequently for the coupling strength as well as pinning control gains, and sufficient conditions are obtained to synchronize and pin a general complex network to a preassigned trajectory. Moreover, some open problems and future works in the field are also discussed.  相似文献   
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