Study of Oxidative Stress in Vitiligo     

Jain A  Mal J  Mehndiratta V  Chander R  Patra SK 《Indian journal of clinical biochemistry : IJCB》2011,26(1):78-81

Vitiligo is an idiopathic, acquired, circumscribed, hypomelanotic skin disorder, characterized by milky white patches of different sizes and shapes. It is due to the destruction of melanocytes resulting in the absence of pigment production of the skin and mucosal surfaces. Oxidative stress has been implicated in pathophysiology of vitiligo. To study the activity of blood Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) in vitiligo patients. A case–control study was conducted in which 100 patients were enrolled after written consent. 50 cases were of active vitiligo and 50 served as control (25 healthy control and 25 with stable vitiligo). SOD—In our study, among the active vitiligo cases 90% had high level of SOD and 10% had normal level of SOD. Among the stable vitiligo controls, 92% had normal level of SOD and 8% had low levels of SOD.The difference between active vitiligo cases and stable vitiligo control as well as with healthy control was statistically significant (P value < 0.05). GPx—Among the active vitiligo cases 74% had normal GPx levels, 22% had low and only 4% had high levels of GPx. Among the stable vitiligo controls, 64% had normal GPx levels, 16% had low, and 20% had high levels of GPx. The difference between active vitiligo cases and stable vitiligo control as well as with healthy control was statistically not significant (P value > 0.05). Our study shows that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of serum superoxide dismutase activity.  相似文献   

Digital Museums and Diverse Cultural Knowledges: Moving Past the Traditional Catalog     

Ramesh Srinivasan  Robin Boast  Jonathan Furner  Katherine M. Becvar 《The Information Society》2013,29(4):265-278

Web 2.0 technologies have introduced increasingly participatory practices to creating content, and museums are becoming interested in the potentials of “Museum 2.0” for reaching and engaging with new audiences. As technological advances are opening up the ways in which museums share information about the objects in their collections, the means by which museums create, handle, process, and transmit knowledge has become more transparent. For this to be done effectively, however, some underlying contradictions must be resolved between museum practices, which privilege the account of the “expert,” and distributed social technology practices, whose strengths lie in allowing for many, sometimes contradictory, perspectives. This article presents a theoretical position and framework for the adaptation of Web 2.0 technologies within the traditional work of the museum, in ways that support the generation and representation of knowledge in, by, and for diverse communities. We then expand on this theoretical perspective by discussing several case studies of exploratory work in this area, and close the article by presenting a few tactical, bottom-up initiatives that museums and distributed communities can take to facilitate the diffusion of this new conceptual framework. Though the subject of this article is online museums, the issues are relevant to all online collections, in particular portals, online public access catalogs (OPAC), and content management systems.  相似文献   

Antidyslipidemic and Antioxidant Activities of Hibiscus rosa sinensis Root Extract in Alloxan Induced Diabetic Rats     

Vishnu Kumar  Farzana Mahdi  Ashok Kumar Khanna  Ranjana Singh  Ramesh Chander  Jitendra Kumar Saxena  Abbas Ali Mahdi  Raj Kumar Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(1):46-50

The antidyslipidemic activity of Hibiscus rosa sinensis (Malvaceae) root extract has been studied in alloxan induced diabetic rats. In this model, oral administration of root extract (500 mg/kg bw. p.o.) for 15 days resulted in significant decreased in the levels of blood glucose, plasma lipids and reactivated post heparin lipoprotein lipase activity in alloxan induced diabetic rats. Furthermore, the root extract (50–500 μg) when tested for its antioxidant activity, inhibited the generation of super oxide anions and hydroxyl radicals, in both enzymic and non enzymic systems in vitro. The results of the present study demonstrated antidyslipidemic and antioxidant activities in root extract of H. rosa sinensis which could be used in prevention of diabetic-dyslipidemia and related complications.  相似文献   

Hematological and Biochemical Parameters in Apparently Healthy Indian Population: Defining Reference Intervals     

Shrilekha Sairam  Suhasini Domalapalli  Sundaram Muthu  Jayanthi Swaminathan  Vivek A. Ramesh  Lalitha Sekhar  Palak Pandeya  Udhaya Balasubramaniam 《Indian journal of clinical biochemistry : IJCB》2014,29(3):290-297

Clinical reference intervals among Indian population are poorly defined. Therefore, there is an urgent need to establish local clinical laboratory reference intervals for healthy Indian population. The present study aimed to identify the 95 % reference interval for hematological and biochemical parameters in apparently healthy Indian population. We undertook a multicentric cross-sectional study conducted at Apollo Hospitals Educational and Research Foundation across India. Of which 10,665 reference individuals identified as healthy by physicians. The 95 % of the reference distribution was estimated using 2.5th and 97.5th percentile reference limits. The 95 % reference intervals for hemoglobin (Males: 12.3–17 g/dL; Females: 9.9–14.3 g/dL), platelet count (Males: 1.3–3.8; Females: 1.3–4.2 Lakhs/µL), erythrocyte sedimentation rate (Males: 2–22; Females: 4–55 mm/h), serum uric acid in males: 3.5–8.2 mg/dL, gamma glutamyl transferase (Males: 13–61 U/L), fasting blood glucose (Males: 78–110 mg/dL), total cholesterol (Males: 115–254 mg/dL), low density lipoprotein (Males: 60–176 mg/dL) and triglycerides (Males: 55–267 mg/dL, Females: 52–207 mg/dL) were different from currently used reference values. Additionally need for gender based partitioning were observed for triglycerides and gamma glutamyl transferase. The observed findings are of clinical significance and it needs to be validated with additional community based studies.  相似文献   

The largest and oldest living organism     

Ramesh Maheshwari 《Resonance》2005,10(4):4-9

A fungus hidden beneath the soil surface in forest, estimated to be 1500–2400 years old, is the largest and oldest living organism.  相似文献   

Conservation of a room: A treatment proposal for Mark Rothko's Harvard Murals     

Jens Stenger  Narayan Khandekar  Ramesh Raskar  Santiago Cuellar  Ankit Mohan  Rudolf Gschwind 《文物保护研究》2016,61(6):348-361

A treatment with projected light for Mark Rothko's Harvard Murals (1962) is proposed. The group of five paintings on canvas has changed color due to the presence of a fugitive red pigment and excessive exposure to natural light in a room with large windows. For the conservation of Rothko's Harvard room, it is brought into context within his other commissions and environments. The original color of the works is determined by the digital restoration of contemporary photographs. With a camera projector system a compensation image is calculated that is projected onto the original canvas resulting in a restored color appearance. This approach of inpainting with light is compared with considerations of cleaning and inpainting in conventional conservation treatments. Overall lighting and architecture including the unusual wall color carefully chosen by Rothko play a key role in the treatment of the Mural cycle as an environment.  相似文献   

Assessment of balance among adolescent track and field athletes     

Adam C. Knight  Megan E. Holmes  Harish Chander  Amari Kimble  Joshua Ty Stewart 《Sports biomechanics / International Society of Biomechanics in Sports》2016,15(2):169-179

Track and field events place different demands on athletes and may have an effect on balance. This study investigated the effects of event specialty, gender, and leg dominance on balance among adolescent track and field athletes. Forty healthy adolescent track and field athletes (male = 23, female = 17) categorised into three different groups (sprinter = 20, distance runners = 13, throwers = 7) had their single leg static balance measured with the eyes open and the eyes closed using an AMTI force platform. Dependent variables included average displacement (cm) of the centre of pressure (COP) in the anterior/posterior direction and medial/lateral directions, the average velocity of the COP (cm/s) and the 95% ellipse area (cm²). Variables were analysed using a 3 (event specialty) × 2 (gender) × 2 (leg) ANOVA with repeated measures on the leg variable (p < 0.05). There was a significant difference (p < 0.05) in the average displacement of the COP in the medial/lateral direction for both the eyes open and closed condition, with the non-dominant leg demonstrating greater displacement than the dominant leg. This might increase the risk of injury for the non-dominant leg, but additional data should be collected and analysed on both dynamic balance and performance.  相似文献   

Antidyslipidemic and antioxidant activities of different fractions of<Emphasis Type="Italic">Terminalia arjuna</Emphasis> stem bark     

Ramesh Chander  Kavita Singh  A K Khanna  S M Kaul  Anju Puri  Rashmi Saxena  Gitika Bhatia  Farhan Rizvi  A K. Rastogi 《Indian journal of clinical biochemistry : IJCB》2004,19(2):141-148

Terminalia arjuna (T. arjuna) stem bark was successively extracted with petroleum ether (A), solvent ether (B), ethanol (C) and water (D). The lipid lowering activity of these four fractions A, B, C, and D was evaluatedin vivo in two models viz., triton WR-1339 induced hyperlipemia in rats as well as fructose rich high fat diet (HFD) fed diabetic- dyslipidemic hamsters. Hyperlipidemia induced by triton caused marked increase in the plasma levels of total cholesterol (Tc), triglyceride (Tg) and phospholipids (PL) in rats. After treament withT. arjuna fractions A, B, C, and D at the doses of 250 mg/kg per oral (p.o.),only the ethanolic fraction (C) exerted significant lipid lowering effect as assessed by reversal of plasma levels of Tc, Tg and PL in hyperlipidemic rats. In another experiment, feeding with HFD produced marked dyslipidemia as observed by increased levels of plasma Tc, Tg, glucose (Glu), glycerol (Gly) and free fatty acids (FFA) in hamsters. After treatment withT. arjuna fractions at the doses of 250 mg/kg p.o. only two fraction (B and C) could exert significant lowering in the plasma levels of lipids and Glu. in dyslipidemic hamsters.In vitro experimentT. arjuna fractions at tested concentrations (50–500 μg/ml) inhibited the oxidative degradation of lipids in human low density lipoprotein and rat liver microsomes induced by metal ions. These fractions when tested against generation of oxygen free radicals at the concentrations (50–500 μg/ml), counteracted the formation of superoxide anions (O⁻²) and hydrodyl radicals (OH) in non enzymic test systems. The efficacy ofT. arjuna fractions as antidyslipidemic and antioxidant agents was found, fraction C> fraction B> fraction A.  相似文献   

Where Information Society and Community Voice Intersect     

Ramesh Srinivasan 《The Information Society》2006,22(5):355-365

Information and communication technology (ICT) development initiatives have begun to acknowledge the power and importance of cultural and community-focused belief systems. Yet the vast majority of such initiatives tend to preidentify developmental goals that communities hold. Paulo Freire's writings have influenced development initiatives by introducing the possibility of working with communities to orient projects. While these “participatory” initiatives have involved soliciting community feedback relative to a research project whose goals were formulated in the university or development institution, they do not go far enough to harness actual visions held by communities. It is important to conceptualize a model and methodology of engaging communities to develop and articulate their own goals of information access and ultimately, an indigenous approach toward cultural, political, and economic aspects of development. This approach holds promise to sustain communities within a return on the investment and efforts of the researcher or institution. This article closes by describing a current initiative in Southern India that reflects the described methodology.  相似文献   

Optimization theory : by David L. Russell. 405 pages. New York,Benjamin, 1970. Price $7.95 (paper-back, $17.50 (hard cover) (approx. £3·15 and £6·32, respectively).     

Ramesh C. Jain 《Journal of The Franklin Institute》1973,296(3):222-223

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