Fields medallists     

Nimish A. Shah 《Resonance》1999,4(11):80-83

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Use of glycated hemoglobin (HbA<Subscript>1C</Subscript>) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population     

Rajes Qvist  Ikram Shah Ismail  Karuthan Chinna  Sekaran Muniandy 《Indian journal of clinical biochemistry : IJCB》2008,23(3):246-249

Although HbA_1C is widely accepted as a useful index of mean blood glucose in type 2 diabetic patients its usefulness as screening test for diabetes has been controversial. The present study was undertaken to determine whether the level of HbA_1C predicted diabetes in a prediabetic group of subjects. Plasma lipids, oral glucose tolerance, HbA_1C was determined in 90 normal control subjects, 57 offspring of one type 2 diabetes mellitus parent and 11 diagnosed type 2 diabetes mellitus individuals. The mean age of participants was 44.5 yrs (not significantly different amongst the three groups) and the mean body mass index was 26.8 (not significantly different amongst the three groups). Two hours after a 75 g glucose challenge, the offspring had a significantly higher plasma glucose level (mean = 7.1 mmol/L, p value = 0.002) than the normals. Similarly the HbA_1C values were higher in the offspring than in the normals (mean = 5.78%, p value = 0.016). Besides the significantly higher values for oral glucose tolerance test and HbA_1C, the diabetics also were significantly higher for triglycerides (mean = 2.25mmol/L), total cholesterol (mean = 6.24mmol/L) and systolic blood pressure (mean = 138.45mm Hg) than the offspring (P value = 0.031, 0.006, 0.010) and the normals (P value = 0.026, 0.018, 0.002) respectively. The mean values of diastolic blood pressure, LDL cholesterol and HDL cholesterol were not significantly different amongst the three groups.  相似文献   

EGFR Mutation Analysis in Non-small Cell Lung Carcinoma Patients: A Liquid Biopsy Approach     

Jigna Joshi  Apexa Raval  Urja Desai  Vinal Upadhyay  Mansi Bhavsar  Kanisha Shah  Rakesh Rawal  Harsha Panchal  Franky Shah 《Indian journal of clinical biochemistry : IJCB》2021,36(1):51

In the era of the targeted therapy identification of EGFR mutation detection in lung cancer is extremely helpful to predict the treatment efficacy of EGFR tyrosine kinase inhibitors (TKIs). Unfortunately, the inadequacy and quality of the biopsy samples are the major obstacles in molecular testing of EGFR mutation in lung cancer. To address this issue, the present study intended to use liquid biopsy as the non-invasive method for EGFR mutation detection. A total of 31 patients with an advanced stage of lung cancer were enrolled in the study from which cell-free DNA (cfDNA) and FFPE tissue DNA was extracted. Extracted DNA samples were analyzed for further EGFR exon specific mutation analysis by ARMS-PCR. Data were analyzed statistically using SPSS software. In cfDNA samples, the prevalence of wild type EGFR was 48% while the prevalence of TKI resistant and TKI sensitive mutations were 3%. Conversely, in tissue DNA samples, the prevalence of wild type, TKI sensitive and TKI resistant mutations were 48%, 19%, and 3%, respectively. The overall concordance of EGFR mutation between cfDNA and tissue DNA was 83%. McNemar’s test revealed that there was no significant difference between EGFR expression of cfDNA and tissue DNA samples. Additionally, the significant-high incidence of TKI resistant mutations was observed in tobacco habituates, indicating the role of carcinogens present in the tobacco in developing resistant mutations. In conclusion, our data suggest that evaluation of EGFR mutation from cfDNA samples is practicable as a non-invasive tool in patients with advanced-stage of lung cancer.  相似文献   

Cognitive and metacognitive learning strategies among Arabic language students     

Ghazali Yusri  Nik Mohd Rahimi  Parilah M. Shah  Wan Haslina Wah 《Interactive Learning Environments》2013,21(3):290-300

This study investigates cognitive and metacognitive strategies in learning oral Arabic among students at Universiti Teknologi MARA (UiTM), Malaysia. The concept of these strategies was derived from the self-regulated learning framework, which consists of five components, namely rehearsal, elaboration, organization, critical thinking, and metacognitive strategies. The purposes of this study are to investigate the level of cognitive and metacognitive strategies used (1) among UiTM students; (2) between students with different prior experiences, namely, some of them had an experience of 5 years in learning Arabic in secondary school (abbreviated by SWE) and some of them did not have any experience at all (abbreviated by SNE); (3) between students of different gender; and (4) between students with the interaction of different gender and prior experience. The sample of this study consists of 183 students and employs a questionnaire adapted from the Motivated Strategies for Learning Questionnaire (MSLQ). The study revealed that (1) all UiTM students used cognitive and metacognitive strategies at a moderate level; (2) SWE scored significantly higher than SNE in all five components of cognitive and metacognitive strategies; (3) females scored significantly higher than males in rehearsal, organization, and metacognitive strategies; and (4) there were no statistically significant differences noted in all components between students with the interaction of prior experience and gender. This study had some classroom implications. It suggested that some improvement and changes in learning oral Arabic should be made in terms of selecting learning materials, implementing oral Arabic activities, and learning tasks, which will stimulate the use of all strategies, as well as conducting proficiency tests instead of achievement tests. Students should also be exposed to the learning techniques which used all these strategies extensively and collaborative activities may be carried out among students with mixed prior experience and gender.  相似文献   

Monitoring Trends in Student Satisfaction     

Grebennikov  Leonid  Shah  Mahsood 《Tertiary Education and Management》2013,19(4):301-322

Over the last decade, the assessment of student experience has gained significant prominence in Australian higher education. Universities conduct internal surveys in order to identify which of their services students rate higher or lower on importance and performance. Thus, institutions can promote highly performing areas and work on those needing improvement, while students are given an opportunity to influence decision-making in both academic and non-academic spheres of campus life. National student surveys conducted by the government aim to maintain quality assurance in the sector, benchmark outcomes, and, in some cases, reward better performing institutions. This paper outlines the findings of a study which monitored the entire student experience in a large metropolitan multi-campus university during 2005–2011. A specially designed biennial survey was repeated across the years, and completed over the period by 10,562 students from all key cohorts. This paper discusses the trends in perceived importance and performance of various university services and key issues the university has been addressing in order to enhance student experience. It concludes that: (a) the time series data provide a powerful lens into the university’s strategies, initiatives and actions which worked well and those needing further effort or adjustment; (b) it is the total experience of the university that shapes students’ judgements, not just what happens in the classroom; and (c) taking a systematic approach to student feedback, and acting on the results in a timely manner, can significantly improve student engagement and satisfaction.  相似文献   

Let’s search together,but not too close! An analysis of communication and performance in collaborative information seeking     

Roberto González-Ibáñez  Muge Haseki  Chirag Shah 《Information processing & management》2013

Communication is considered to be one of the most essential components of collaboration, but our understanding as to which form of communication provides the most optimal cost-benefit balance lacks severely. To help investigate effects of various communication channels on a collaborative project, we conducted a user study with 30 pairs (60 participants) in three different conditions – co-located, remotely located with text chat, and remotely located with text as well as audio chat, in an exploratory search task. Using both quantitative and qualitative data analysis, we found that teams with remotely located participants were more effective in terms of being able to explore more diverse information. Adding audio support for remote collaboration helped participants to lower their cognitive load as well as negative emotions compared to those working in the same space. We also show how these findings could help design more effective systems for collaborative information seeking tasks using adequate and appropriate communication. We argue that collaboration is an important aspect of human-centered IR, and that our work provides interesting insights into people doing information seeking/retrieval in collaboration.  相似文献   

Application of machine learning in higher education to assess student academic performance,at-risk,and attrition: A meta-analysis of literature     

Fahd  Kiran  Venkatraman  Sitalakshmi  Miah  Shah J.  Ahmed  Khandakar 《Education and Information Technologies》2022,27(3):3743-3775

Education and Information Technologies - Recently, machine learning (ML) has evolved and finds its application in higher education (HE) for various data analysis. Studies have shown that such an...  相似文献   

The determinants of individuals’ perceived e-security: Evidence from Malaysia     

Mahmood Hussain Shah  Hamid Reza Peikari  Norjaya M. Yasin 《International Journal of Information Management》2014

Despite the critical role of individuals’ perceived security in an online environment, previous research has not attempted to comprehensively study the influences and interrelations between the determinants of online individuals’ perceived security. This research employs five theories to examine the interrelations that might exist between the antecedents of individuals’ perceived security in online environment in Malaysia. It is the first attempt to empirically examine the interrelations of the confidentiality related factors identified in the literature which is a significant original contribution. A questionnaire was the primary research methodology and structural equation modeling was employed to test the hypotheses. The findings suggest that individuals’ perceptions about security are significantly influenced by their perceived technical protection while technical protection was found to be influenced by website design features. Moreover, it was found that individuals’ perceptions toward internally provided assurances are highly influenced by externally provided assurances. However, the results found no significant relations between internally and externally provided assurances about a website's security. The findings imply that e-retailers should launch well-designed websites and communicate the technical protection capabilities of their websites to address individuals’ security concerns. The results also suggest that e-traders should consider the factors influencing individuals’ security perceptions when designing/developing their websites.  相似文献   

Design of Allele Specific PCR for Rapid Detection of CYP3A5 (A6986G) and Mdr-1 (C3435T) Polymorphisms     

Ashavaid TF  Raje HS  Shah BV  Shah SA 《Indian journal of clinical biochemistry : IJCB》2011,26(1):18-21

Single nucleotide polymorphisms in CYP3A5 (A6986G) and MDR-1 (C3435T) genes have been shown to be associated with the pharmacokinetics of tacrolimus in case of renal transplant recipients. Knowing these genotypes of the recipients before undergoing transplantation, is therefore essential for physicians to adjust the starting dose of tacrolimus in order to avoid drug induced nephrotoxicity. We have designed an allele specific PCR method for easier and rapid detection of these polymorphisms. 20 Indian renal transplant recipients on tacrolimus who developed nephrotoxicity within 1 month of transplantation and 58 Indian non-transplant subjects having the risk factors for kidney disease i.e. hypertension or diabetes or the family history of these, have been studied for these SNPs by allele specific PCR method. The data suggest that the heterozygosity of CYP3A5 and mutant allele frequency of MDR-1 SNP is higher in transplant patients as well as in general population.  相似文献   

Muslim learners in English schools: a challenge for school leaders   总被引：1，自引：0，他引：1  

Saeeda Shah 《牛津教育评论》2013,39(4):523-540

Faith identity is emerging as significant for Muslim students in the post 9/11 scenario, with implications for their education and wider social cohesion. This poses challenges to school leaders, raising issues not only linked to student achievement and performance, but also with regard to students’ identity constructions and their educational engagement. The paper draws on data collected from a small number of teachers and Muslim students from two secondary schools in England, looking at how Muslim students experience their identity in the school context and with what implications for their educational engagement. It also discusses the challenges for educational leaders/teachers in managing ‘Muslimness’ on educational sites. The data indicate that the increasing engagement with faith identity can be a response to experiences of discrimination, marginalisation and negative media. The paper highlights the need for communication and understanding across differences, underpinned by an equally pressing need for the recognition of religious and cultural diversity.  相似文献