俄罗斯学者眼中的新经济政策──中俄学者关于新经济政策的对话     

B．Л．捷利钦  张广翔 《河南师范大学学报(哲学社会科学版)》1999,(5)

张广翔（以下简称张）：先是苏联,继之俄罗斯进行的改革进程涉及政治、经济、文化和社会生活的所有方面,不能不触及史学。尤其在这种全方位改革情况之下,社会开始关注以往的历史,试图解释正在发生的事情,并在某种程度上猜测可能的后果,因而,新经济政策时期成为20世纪80年代下半期苏联史学界的研究热点。能否用同样方法解释今天学术界对新经济政策问题兴趣的减少呢？B刀．捷利钦（以下简称捷）：戈尔巴乔夫改革时期曾一度引起新经济政策研究骤然升温。在苏联解体之后,尤其是今天的俄罗斯对这个问题的研究完全是两样：有关20世纪20年…  相似文献   

开架借书式     

(捷P.马莱克 《中国图书馆学报》1959,(3)

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纳尼亚传奇(四) 阿斯兰的消息     

C.S.刘易斯  一慢  花兔兔 《阅读》2023,(42):32-35

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纳尼亚传奇（七） 初战告捷     

C.S.刘易斯  一慢  花兔兔 《阅读》2023,(74):32-35

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Thermal mixing of two miscible fluids in a T-shaped microchannel     

Xu B  Wong TN  Nguyen NT  Che Z  Chai JC 《Biomicrofluidics》2010,4(4):44102

In this paper, thermal mixing characteristics of two miscible fluids in a T-shaped microchannel are investigated theoretically, experimentally, and numerically. Thermal mixing processes in a T-shaped microchannel are divided into two zones, consisting of a T-junction and a mixing channel. An analytical two-dimensional model was first built to describe the heat transfer processes in the mixing channel. In the experiments, de-ionized water was employed as the working fluid. Laser induced fluorescence method was used to measure the fluid temperature field in the microchannel. Different combinations of flow rate ratios were studied to investigate the thermal mixing characteristics in the microchannel. At the T-junction, thermal diffusion is found to be dominant in this area due to the striation in the temperature contours. In the mixing channel, heat transfer processes are found to be controlled by thermal diffusion and convection. Measured temperature profiles at the T-junction and mixing channel are compared with analytical model and numerical simulation, respectively.  相似文献   

Herceptin functionalized microfluidic polydimethylsiloxane devices for the capture of human epidermal growth factor receptor 2 positive circulating breast cancer cells     

Thierry B  Kurkuri M  Shi JY  Lwin LE  Palms D 《Biomicrofluidics》2010,4(3):32205

Building on recent breakthroughs in the field of microfluidic-based capture of rare cancer cells circulating in the blood, the present article reports on the use of Herceptin functionalized PDMS devices designed to efficiently capture from blood cancer cells, overexpressing the tyrosine kinase human epidermal growth factor receptor (HER2). The identification of patients overexpressing HER2 is critical as it typically associates with an aggressive disease course in breast cancer and poor prognosis. Importantly, HER2 positive patients have been found to significantly benefit from Herceptin (Trastuzumab), a humanized monoclonal antibody (MAb) against HER2. Disposable PDMS devices prepared using standard soft lithography were functionalized by the plasma polymerization of an epoxy-containing monomer. The epoxy-rich thin film (AGEpp) thus created could be conjugated with Herceptin either directly or through a polyethylene glycol interlayer. The properties and reactivity toward the monoclonal antibody conjugation of these coatings were determined using x-ray photoelectron spectroscopy; direct conjugation provided a good compromise in reactivity and resistance to biologically nonspecific fouling and was selected. Using the breast cancer cell line SK-BR-3 as a model for cells overexpressing HER2, the immunocapture efficacy of the Herceptin functionalized PDMS was demonstrated in model studies. Validation studies confirmed the ability of the device to efficiently capture (～80% capture yield) HER2 positive cells from full blood.  相似文献   

An integrated microfluidic cell array for apoptosis and proliferation analysis induction of breast cancer cells     

Song H  Chen T  Zhang B  Ma Y  Wang Z 《Biomicrofluidics》2010,4(4):44104

In vitro sensitivity testing of tumor cells could rationalize and improve the choice of chemotherapy and hormone therapy. In this report, a microfluidic device made from poly(dimethylsiloxane) and glass was developed for an assay of drug induced cytotoxicity. We evaluated the apoptotic and proliferation-inhibitory effects of anticancer drugs mitomycin C (MMC) and tamoxifen (TAM) using MCF-7 breast cancer cells. MMC and TAM both induced apoptosis and inhibited proliferation of MCF-7 cells in a concentration-dependent manner. MMC caused the expression of antiapoptotic protein Bcl-2 a dose-dependent reduction in MCF-7 cells. The expression of Bcl-2 did not change significantly in MCF-7 cells treated by TAM. The results in the microfluidic device were correlated well with the data obtained from the parallel experiments carried out in the conventional culture plates. The developed microfluidic device could be a potential useful tool for high content screening and high throughput screening research.  相似文献   

Polyelectrolyte multilayer surface functionalization of poly(dimethylsiloxane) (PDMS) for reduction of yeast cell adhesion in microfluidic devices     

Schmolke H  Demming S  Edlich A  Magdanz V  Büttgenbach S  Franco-Lara E  Krull R  Klages CP 《Biomicrofluidics》2010,4(4):44113

Polyelectrolyte multilayers (PEMs) based on the combinations poly(diallyldimethylammonium chloride)∕poly(acrylic acid) (PDADMAC∕PAA) and poly(allylamine hydrochloride)∕PAA (PAH∕PAA) were adsorbed on poly(dimethylsiloxane) (PDMS) and tested for nonspecific surface attachment of hydrophobic yeast cells using a parallel plate flow chamber. A custom-made graft copolymer containing poly(ethylene glycol) (PEG) side chains (PAA-g-PEG) was additionally adsorbed on the PEMs as a terminal layer. A suitable PEM modification effectively decreased the adhesion strength of Saccharomyces cerevisiae DSM 2155 to the channel walls. However, a further decrease in initial cell attachment and adhesion strength was observed after adsorption of PAA-g-PEG copolymer onto PEMs from aqueous solution. The results demonstrate that a facile layer-by-layer surface functionalization from aqueous solutions can be successfully applied to reduce cell adhesion strength of S. cerevisiae by at least two orders of magnitude compared to bare PDMS. Therefore, this method is potentially suitable to promote planktonic growth inside capped PDMS-based microfluidic devices if the PEM deposition is completed by a dynamic flow-through process.  相似文献   

我们都曾是哭鼻子的小屁孩儿     

dad.震 《当代体育》2010,(2):78-80,F0003

那时花开,流水芳年。 青春很锋利,很容易就划开记忆的容颜,岁月如梭,稍纵即逝,我们还没来得及回忆青涩和苦涩,感受阵痛和欣喜,时间就呼啸而过了。  相似文献   

虎年说虎     

H.tiger 《当代体育》2010,(6)

——现役脑残之王:马布里作为当年96黄金一代的球员之一,马布里如今的生活简直可以用穷困潦倒来形容,自从当年他自称天下第一控卫起,马布里的生涯评定便每况愈下。自此,马布里就开始了与全世界对抗的戏码。最初在森林狼,他就因不满加内特拿到亿元高薪而愤然离开,拆散了一对本该是黄金搭档的组合。在转投纽约后,尽管身为纽约之子,但尼克斯宁可掏出两千万也要请这位大爷走人。自从被尼克斯队抛弃之  相似文献