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991.
N. A. Slashcheva S. A. Vlasova N. V. Mironova 《Scientific and Technical Information Processing》2011,38(4):258-264
This paper reflects the results of the analysis of user information needs that was carried out by the Library of Natural Sciences
of the Russian Academy of Sciences (LNS RAS) for the purpose of gathering information on the quality of a reference-bibliographic
and information service for specialists of the RAS in the subject of their studies. 相似文献
992.
Farrokhi E Shayesteh F Asadi Mobarakeh S Roghani Dehkordi F Ghatreh Samani K Hashemzadeh Chaleshtori M 《Indian journal of clinical biochemistry : IJCB》2011,26(3):244-248
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations
in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH
has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran.
The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related
Iranian possible FH subjects were studied. Diagnosis of FH was based on the Dutch Lipid Clinic Network diagnostic criteria.
All samples were initially tested for three common APOB gene mutations including R3500Q, R3500 W and R3531C using PCR-RFLP
assay. Subsequently, promoter and coding region of the LDLR gene was screened by PCR-SSCP analysis and positive results were
confirmed by DNA sequencing. Four previously reported polymorphisms 1413G > A, 1725C > T, 1773T > C and 2140 + 5G > A were
found in ~17% (5/30) of population studied. Moreover, no variation was found in APOB gene. Our data indicated that LDLR and
APOB gene mutations have not contribution to possible FH in Iranian population studied here. However, we examined three common
APOB mutations and LDLR in only 30 patients, and to determine the role of these genes in developing FH in Iran, more FH samples
and populations needed to be investigated for the mutations of the related genes. 相似文献
993.
D. Puri K. M. Prabhu G. Dev S. Agarwal P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2011,26(4):335-346
To study the mechanism of action of water soluble compound GII purified from fenugreek (Trigonella foenum graecum) seeds which was shown earlier to have antidiabetic effect in the subdiabetic, moderately and severely diabetic rabbits.
In rabbits (1–1.5 kg bw) diabetes was induced by intravenous injection of 80 mg/kg bw of alloxan. They were fed with GII at
a dose of 50 mg/kg bw daily once in the morning for 15 days in the subdiabetic and moderately diabetic and 30 days in the
severely diabetic rabbits. Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol
[(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway)
hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase
and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase
were estimated. Liver and kidney function parameters were also estimated. Treatment with GII for 15 days in the subdiabetic
and moderately diabetic rabbits and for 30 days in the severely diabetic rabbits (i) decreased the elevated lipids TC, TG,
(LDL + VLDL)C and increased the decreased (HDL)C, (ii) decreased the elevated liver and heart total lipids, TC and TG, (iii)
increased the decreased liver and muscle glycogen, (iv) increased the decreased hexokinase, glucokinase, pyruvate kinase,
malic enzyme, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutathione peroxidase, (v) decreased the increased
glucose-6-phosphatase, sorbitol dehydrogenase, aldose reductase. Results thus show that treatment with GII compound purified
from fenugreek seeds for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits corrects
the altered serum lipids, tissue lipids, glycogen, enzymes of glycolysis, gluconeogenesis, glycogen metabolism, polyol pathway
and antioxidant enzymes. Histopathological abnormalities (fatty infiltration and other cellular changes) seen in the pancreas,
liver, heart and kidneys were repaired after treatment with GII. In fact partially damaged pancreas was repaired. Liver and
kidney function test results were normal in the GII treated animals indicating that GII treatment is safe and free from any
side effects. 相似文献
994.
We report a case of a diabetic, heterozygote with near normal hematology, marginally low level of hemoglobin A2(HbA2) having an increased level of hemoglobin F(HbF) that was pancellularly distributed among the red cells. BioRad DiaSTAT measurements
gave a high glycated hemoglobin A1c(HbA1c) of 31.5% and the BioRad Variant analyzer recorded an HbA1c value which was very
low, in discordance with the detected blood glucose levels. Flow cytometry and polymerization chain reaction (PCR) based studies
were carried out which revealed the case to be that of the common hereditary persistence of fetal hemoglobin (HPFH)-3, an
Asian Indian mutation. Fructosamine estimation and HbA1c by Boronate affinity chromatography were able to resolve the discordant
value detected and was able to confirm the diabetes status. The case would have been a diagnostic dilemma, if reported without
correlation. 相似文献
995.
India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life
span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis
in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1)
to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women
and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy
(alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically
diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited
as control. Mean bone mineral density T score and Z score was significantly decreased (P < 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of
BMD—T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels
were significantly increased (P < 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P < 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor
of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of
osteoporosis and for monitoring responses to antiresorptive therapy. 相似文献
996.
Franky D. Shah Rasheedunnisa Begum Bhairavi N. Vajaria Kinjal R. Patel Jayendra B. Patel Shilin N. Shukla Prabhudas S. Patel 《Indian journal of clinical biochemistry : IJCB》2011,26(4):326-334
Oral cancer has emerged as an alarming public health problem with increasing incidence and mortality rates all over the world.
Therefore, the implementation of newer screening and early detection approaches are of utmost importance which could reduce
the morbidity and mortality associated with this disease. Sensitive and specific biomarkers for oral cancer are likely to
be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. Unlike other deep cancers,
oral cancer is located in oral cavity. Hence, the direct contact between saliva and oral cancer lesion makes the measurement
of tumor markers in saliva an attractive alternative to serum and tissue testing. The DNA, RNA and protein molecules derived
from the living cancer cells can be conveniently obtained from saliva. Thus, salivary biomarkers, a non-invasive alternative
to serum and tissue-based biomarkers may be an effective modality for early diagnosis, prognostication and monitoring post
therapy status. In the current post-genomic era, various technologies provide opportunities for high-throughput approaches
to genomics and proteomics; which have been used to evaluate altered expressions of gene and protein targets in saliva of
oral cancer patients. The emerging field of salivary biomarkers has great potentials to prove its clinical significance to
combat oral cancer. Hence, we have reviewed importance of several salivary genomics and proteomics biomarkers for oral cancer. 相似文献
997.
The European university landscape: A micro characterization based on evidence from the Aquameth project 总被引:2,自引:0,他引:2
Cinzia Daraio Andrea BonaccorsiAldo Geuna Benedetto LeporiLaurent Bach Peter BogetoftMargarida F. Cardoso Elena Castro-MartinezGustavo Crespi Ignacio Fernandez de LucioHarold Fried Adela Garcia-AracilAnnamaria Inzelt Ben JongbloedGerhard Kempkes Patrick LlerenaMireille Matt Maria OlivaresCarsten Pohl Tarmo RatyMaria J. Rosa Cláudia S. SarricoLéopold Simar Stig SlipersaeterPedro N. Teixeira Philippe Vanden Eeckaut 《Research Policy》2011,40(1):148-164
This paper provides a new and systematic characterization of 488 universities, from 11 European countries: Finland, France, Germany, Hungary, Italy, Netherlands, Norway, Portugal, Spain, Switzerland and UK. Using micro indicators built on the integrated Aquameth database, we characterize the European university landscape according to the following dimensions: history/foundation of university, dynamics of growth, specialization pattern, subject mix, funding composition, offer profile and productivity. 相似文献
998.
The aim of this paper is to present a reliability modeling and analysis of a two-unit system of a continuous casting (CC) plant. Real maintenance data of a steel production plant have been used for the purpose. Three types of failures were noted: repairable, replaceable and reconditioning/reinstallation. The two-unit system is operating in parallel, on full-reduced installed capacity. Upon the unit failure, an inspection is carried out to decide the type of maintenance task to be performed. Optimized reliability indices of the plant such as mean time to system failure, availability, expected busy periods of the repairman for various maintenance tasks, expected number of visits by the repairman, expected number of repairs, replacements and reconditioning/reinstallation are obtained. Semi-Markov processes and regenerative point techniques are used for the analysis. Profit incurred to the CC plant is also evaluated and related graphs are plotted to demonstrate the results. 相似文献
999.
Analytical expressions are derived from a single symmetrical relay feedback test for the identification of open loop stable and unstable non-minimum phase processes. The second derivative of the limit cycle output helps in finding the time delay of the process. The derived expressions can be used to identify the process models with up to five unknowns. The effectiveness of the proposed identification method is verified through different simulation results. 相似文献
1000.
This paper studies bounded input bounded output (BIBO) stability for a class of neutral systems with time-varying delays. Based on Lyapunov method and linear matrix inequalities, some new BIBO stability criteria are established. The numerical simulation is made to demonstrate the effectiveness of the theoretical results obtained in this paper. 相似文献