The effect of degrees of direction in the qualitative analysis laboratory on retention of learning     

Charlie M. Holcomb 《科学教学研究杂志》1971,8(2):165-169

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Getting mobile right: start with who and why,not what and how     

Charlie RAPPLE 《Learned Publishing》2012,25(4):252-257

Mobile dominance is imminent. Getting mobile wrong means losing market share to disruptors; getting it right gives us an opportunity to rebuild relationships with our audience. It is the audience, therefore, that should direct mobile strategy. This means starting by researching the workflows and challenges of different segments, to understand how to add value (not just bells‐and‐whistles). We must prioritize mobile in our product development and innovation, freeing it from the ‘print + online’ paradigm so that it can fulfil different kinds of information needs and objectives. This article advocates a back‐to‐basics approach that puts audiences (not content, and not technology) at the centre of mobile strategy, and explores market segmentation and research, innovation, business models, development choices, and the wider organizational implications of getting mobile right.  相似文献   

Estimates of the number of people in England who attain or exceed vigorous intensity exercise by walking at 3 mph     

Paul Kelly  Marie Murphy  Pekka Oja  Elaine M. Murtagh  Charlie Foster 《Journal of sports sciences》2013,31(15):1629-1634

Abstract

Walking is a safe, accessible and low cost activity, amenable to change and known to have great potential to increase physical activity levels in sedentary individuals. The objective of this study is to estimate the proportion of the 2009 adult population of England who would attain or exceed vigorous intensity activity (>70% maximum heart rate [HR_max]) by walking at 3 mph. We conducted predictive impact modelling using participants' (n = 1741, aged 25–64 years) cardiovascular fitness data from treadmill walking tests. We combined this data with English population estimates adjusted for age and sex to estimate the numbers of individuals that would exceed 70% HR_max (an intensity considered sufficient for fitness gains) when walking at 3 mph (4.8 km · h^?1). We estimate 1.5 million men (95% confidence interval [CI] 0.9–2.2 million) (from 13.4 million corresponding to 11.6% (95% CI 7.0–16.2%)) and 3.9 million women (95% CI 3.0–4.8 million) (from 13.6 million corresponding to 28.6% (95% CI 22.0–35.1%)) in England aged 25–64 years would benefit from regularly walking at 3 mph. In total, a projected 5.4 million individuals (95% CI 3.9–6.9 million) aged 25–64 (from 26.97 million corresponding to 20.1% (95% CI 14.6–25.7%)) could benefit from walking at 3 mph. Our estimates suggest a considerable number of individuals in the English population could receive fitness and health benefits by walking regularly at 3 mph. Physical activity messages that promote walking at this speed may therefore have the potential to significantly impact national fitness levels and health in England.  相似文献   

Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma     

Bing-yu Xiang  Lu Chen  Xiao-jun Wang  Charlie Xiang 《Journal of Zhejiang University. Science. B》2017,18(9):737-746

Mesenchymal stem cells (MSCs) are plastic-adherent cells with a characteristic surface phenotype and properties of self-renewal, differentiation, and high proliferative potential. The characteristics of MSCs and their tumortropic capability make them an ideal tool for use in cell-based therapies for cancer, including glioma. These cells can function either through a bystander effect or as a delivery system for genes and drugs. MSCs have been demonstrated to inhibit the growth of glioma and to improve survival following transplantation into the brain. We briefly review the current data regarding the use of MSCs in the treatment of glioma and discuss the potential strategies for development of a more specific and effective therapy.  相似文献   

Eigenvalue localization for the tikhonova model of crystal growth     

Charlie H. Cooke  Philip W. Smith 《Journal of The Franklin Institute》1983,316(2):127-133

Matrix A with characteristic polynomial Q(z) is defined positive or negative Hurwitz according to whether Q(z) or Q(-z) is a Hurwitz polynomial. Leading principle sections of the Tikhonova growth matrix have associated characteristic polynomials P_n(-z) which satisfy the recursionThat the Tikhonova growth matrix is negative Hurwitz is established through applying the Wall-Stieltjes theory of continued fraction expansions to show the P_n(-z) are Hurwitz polynomials. The Kayeya-Enestrom theorem and a procedure for refinement of the Gerschgorin estimate are used to obtain analytical bounds on spectral radii for the Tikhonova model, which provides estimates of maximal growth rates. The theory allows generalization to more complicated growth models.  相似文献   

Mapping undergraduate chemistry students' epistemic ideas about models and modeling     

Katherine Lazenby  Avery Stricker  Alexandra Brandriet  Charlie A. Rupp  Kathryn Mauger-Sonnek  Nicole M. Becker 《科学教学研究杂志》2020,57(5):794-824

Developing and using scientific models is an important scientific practice for science students. Undergraduate chemistry curricula are often centered on established disciplinary models, and assessments typically provide students with opportunities to use these models to predict and explain chemical phenomena. However, traditional curricula generally provide few opportunities for students to consider the epistemic nature of models and the process of modeling. To gain a sense of how introductory chemistry students understand model changeability, model multiplicity, the evaluation of models, and the process of modeling, we use a construct-mapping approach to characterize the sophistication of students' epistemic knowledge of models and modeling. We present a set of four related construct maps that we developed based on the work of other scholars and empirically validated in an undergraduate introductory chemistry setting. We use the construct maps to identify themes in students' responses to an open-ended survey instrument, the models in chemistry survey, and discuss the implications for teaching.  相似文献   

The impact of gastrostomy feeding tubes on the early childhood education and care of young children     

Charlie Swan 《Support for Learning》2021,36(4):555-571

This article explores how gastrostomy feeding tubes can impact the early childhood education and care (ECEC) experiences of children. It presents findings from a small-scale study, which utilised the perspectives of early years educators and parents. The findings indicate that feeding tubes have both an opportunistic and restrictive impact within ECEC. Opportunity was evident through improved nutrition and health, which allowed familial respite and an increased attendance of ECEC. This enabled opportunities for social and explorative interactions. However, the complexities of having and supporting a feeding tube made accessing types of play and exploration challenging. Collaboration between the educators and parents was a crucial tool for success. Educators felt with experience and teamwork they could ensure the needs of children were met innovatively and safely. However, it was concluded clearer advice for attending ECEC settings with a feeding tube would benefit all involved and instil a sense of readiness.  相似文献   

Human adult stem cells from menstrual blood and endometrial tissue     

Julie Allickson  Charlie Xiang 《Journal of Zhejiang University. Science. B》2012,13(5):419-420

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Preserving the Past: An Early Interview Improves Delayed Event Memory in Children With Intellectual Disabilities          下载免费PDF全文

Deirdre A. Brown  Charlie N. Lewis  Michael E. Lamb 《Child development》2015,86(4):1031-1047

The influence of an early interview on children's (N = 194) later recall of an experienced event was examined in children with mild and moderate intellectual disabilities (CWID; 7–12 years) and typically developing (TD) children matched for chronological (7–12 years) or mental (4–9 years) age. Children previously interviewed were more informative, more accurate, and less suggestible. CWID (mild) recalled as much information as TD mental age matches, and were as accurate as TD chronological age matches. CWID (moderate) recalled less than TD mental age matches but were as accurate. Interviewers should elicit CWID's recall as early as possible and consider developmental level and severity of impairments when evaluating eyewitness testimony.  相似文献   

Competence is in the Eye of the Beholder: Perceptions of intellectually disabled child witnesses     

Deirdre A. Brown  Charlie N. Lewis 《International Journal of Disability, Development & Education》2013,60(1):3-17

This study examines mock jurors’ perceptions of a young witness according to whether or not he was described as having an intellectual disability. Our study examined perceptions of a child witness younger (five or seven years) than previously studied. Mock jurors (n = 71) viewed a short video excerpt of a boy recalling a personally experienced event, and then rated him across nine domains of eyewitness ability. The boy was described as either having an intellectual disability or typically developing. Participants rated the child more negatively on dimensions relating to cognitive competence, but not trustworthiness, when he was presented as having an intellectual disability. Participants also watched the child answer a series of suggestive questions; when described as having an intellectual disability he was rated as less accurate in responding to these. The findings have implications for the involvement of children with intellectual disabilities within the legal system.  相似文献