Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Mediated absent presence in forced displacement     

Mirjam A. Twigt 《Popular Communication》2019,17(2):171-184

ABSTRACT

For many forcefully displaced people worldwide, notions around one’s sense of “home” and “place” in the world are perpetually unsettled. This article explores how digital technologies interact with embodied, material experiences within the geographical location refugees are residing in. Empirical examples from ethnographic research conducted among Iraqi urban refugees, living in prolonged uncertainty in Jordan, shows how situated experiences of legal, material, and social uncertainty reinforce particular mediated socialities. Pivotal studies have shown how digital connections engender virtual home-making practices and a wide variety of connected presences. This study points to the other side of the same coin: the cultivation of “absent presence.” “Absent presence” refers to feelings—the ambivalence that experiences of prolonged displacement bring about—but also to active disengagement and affective tactics in response. These engender a further separation from the physical world where forced migrants are not deemed welcome.  相似文献   

Cruelty and Afrofuturism     

Lonny J. Avi Brooks 《传播与批判/文化研究》2018,15(1):101-107

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学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献   

基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例     

李东巧  陈芳  韩涛  杨艳萍  王学昭  王燕鹏  Cynthia Liu  Yingzhu Li 《图书情报工作》2020,64(21):120-129

[目的/意义] 通过构建二模复杂网络模型，揭示隐藏在海量文献中的隐性知识。[方法/过程] 通过NetworkX复杂网络工具包，依据任意两个节点的共现关系构建二模复杂网络模型；对网络模型中节点的共现关系进行加权，计算网络的拓扑信息并进行AP聚类，提取节点间的直接关系；采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价，遴选出最合适的预测算法，并对复杂网络的隐性关系进行预测分析。[结果/结论] 以潜在药物靶点挖掘为例进行的实证研究结果表明，wAA链路预测算法为最优的链路预测算法；二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试，以进一步验证该模型的通用性和有效性。  相似文献   

Olfaction and emotion: The quest for olfactory restoration in two speech communities     

Sally O. Hastings  Trudy Milburn 《Journal of International and Intercultural Communication》2019,12(2):190-207

ABSTRACT

Olfaction has been described as one of the least studied of the senses. This has certainly proven true in Communication. This project applies Ethnography of Communication and Cultural Discourse Analysis to examine the role that olfaction plays in the cultural meaning systems of two speech communities: residents surrounding the Gowanus Canal and bereaved parents. The cultural hub used to explore the cultural significance of olfaction in both speech communities is feeling. The analyses illustrate how emotions are tied to associated sensations and further become activated through radiants of dwelling, relating and acting. The analysis also shows how olfaction may serve to unify and separate members of a community. The significance of this research encourages stretching the boundaries of communication studies by examining the less studied physical senses and the boundaries of Cultural Discourse Analysis by providing distinctions that others can incorporate when examining feelings.  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

Deep teaching in a college STEM classroom     

Dewsbury  Bryan M. 《Cultural Studies of Science Education》2020,15(1):169-191

Cultural Studies of Science Education - The retention of underrepresented students remains a significant challenge in the STEM (Science, Technology, Engineering and Math) disciplines. A broad range...  相似文献   

Nurturing leadership: equitable mentoring for the superintendency     

Ava J. Muñoz  Anita M. Pankake  Shirley Mills  Marie Simonsson 《International Journal of Leadership in Education》2018,21(3):284-292

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韩国电子竞技发展的特点及其对我国的启示     

孙勤燕  刘才金 《体育科技文献通报》2020,(6):120-121,124

通过对韩国电子竞技的发展及现状进行研究分析,发现其主要得益于政府政策的大力扶植;良好的社会群众基础;优秀的人才培养体系;媒体、企业的大力支持等。同时为我国电子竞技日后的良好发展提出以下建议:制定相关政策法规,加大政府对电竞的支持度;创设良好的舆论氛围,增强社会对电竞的认可度;完善人才培养体系,为电竞发展输送优质人才;加强媒体正面报道,吸引大型企业的资金帮助。  相似文献