Circadian rhythms     

Koustubh M. Vaze  Vijay Kumar Sharma 《Resonance》2013,18(7):662-672

Living organisms ranging from bacteria to human beings exhibit 24-h rhythms in various behaviours and physiological processes. Matching of the period of such rhythms with that of the daily environmental cycles gives an impression that they are mere passive responses to environmental changes. Here, we discuss the change in our perception about daily biological rhythms, from their identity as rhythmic phenomena occurring as passive response to environmental changes, to the biological clocks. This is the first article in a series of articles on circadian rhythms which will cover discussion on the genetic and molecular basis, circadian organization and its adaptive significance.  相似文献   

Open learning in India: evolution,diversification and reaching out     

Ramesh C. Sharma 《Open Learning》2013,28(3):227-241

Distance education has a history of over four decades in India. There has been a vast growth in the number of learners who need education and thus also the corresponding channels of providing education. Due to the constraints of the traditional educational sector, open and distance learning has been found to be a workable alternative strategy in India. This paper traces the evolution and diversification of open learning in India by examining various factors that led to the growth and success of open learning. This system, as other systems of education, is not free from problems and a critique is provided on the various factors affecting the smooth functioning of India’s open and distance learning system.  相似文献   

Effects of Active Learning on Enhancing Student Critical Thinking in an Undergraduate General Science Course     

Kyoungna Kim  Priya Sharma  Susan M. Land  Kevin P. Furlong 《Innovative Higher Education》2013,38(3):223-235

To enhance students’ critical thinking in an undergraduate general science course, we designed and implemented active learning modules by incorporating group-based learning with authentic tasks, scaffolding, and individual reports. This study examined the levels of critical thinking students exhibited in individual reports and the students’ critical thinking level change over time. Findings indicated that students’ average critical thinking level fell in the category of “developing”, but students’ scores on individual reports revealed a statistically significant increase. The study suggested that the active learning strategies employed in the study were useful to promote student critical thinking.  相似文献   

Reactive oxygen species,reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2     

P. P. Singh  Farzana Mahadi  Ajanta Roy  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(4):324-342

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Effect of oral ingestion of different forms of silver on tissue content of some essential elements in chicks     

D. C. Sharma  Gora Dadheech  Bushra Fiza  Meghna Mathur  Manminder Riyat  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):202-204

Silver is ingested in India in the form of varak, Ayurvedic bhasm and water contained in silver utensils, but nobody knows their effects. We have examined the effect of interaction of silver ingested in the form of varak (leaf), bhasm (ash) and water (colloidal solution) on some essential elements (Na, K, Ca, Mg, Cu, Fe and Zn) in blood, liver, spleen and kidneys of chicks. The results showed significant rise of silver in all the tissues and significant fall in copper in the blood. The greatest rise was obtained in blood silver by silver sol while it had the lowest amount of silver. Iron significantly increased in tissues but somewhat decreased in blood. Zinc content increased in all the tissues by leaf and ash but decreased by sol. No consistent pattern was seen in case of other elements.  相似文献   

hs-CRP and oxidative stress in young CAD patients: A pilot study     

Suman B. Sharma  Seema Garg  Abhinav Veerwal  Sridhar Dwivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):334-336

Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40 years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde, antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians.  相似文献   

Preliminary studies on the detection ofMycobacterium avium-intracellulare complex using DNA probe from a clinical isolate     

P. Sharma  M. Bose  Isa Mohd  S. Bagdi  H. G. Raj 《Indian journal of clinical biochemistry : IJCB》2000,15(2):83-87

Genomic DNA from a clinical isolate ofMycobacterium avium-intracellulare complex was purified and cloned in PBR 322 at the tetracycline resistance site using Bam HI restriction enzyme. A 16 kb cloned fragment was purified, radiolabeled and used as a probe. Genomic DNA isolated from nineteen MAC strains, threeM. tuberculosis strains and oneM. kansasii strain were digested with Eco RI restriction enzyme, Southern blotted and hybridized with the 16 kb cloned and labeled fragment. Twelve MAC strains showed positive hybridization although five strains gave faint signals. Positive hybridization was noted in two out of the threeM. tuberculosis strains, possibly due to shared DNA homology. No signal was received from the singleM. kansasii strain used in this study.  相似文献   

Carbohydrate gel ingestion during running in the heat on markers of gastrointestinal distress     

Jenna Sessions  Kelsey Bourbeau  Mattina Rosinski  Taylor Szczygiel  Rachael Nelson  Naveen Sharma 《European Journal of Sport Science》2016,16(8):1064-1072

The purpose of this study is to measure the effects of carbohydrate ingestion during exercise in the heat by measuring markers of gastrointestinal damage and inflammation. Methods: Active subjects (n?=?7) completed two 60-min running trials in a heated environment (70% VO₂max, 30°C). At minute 20 of exercise, subjects consumed a carbohydrate gel (Cho) (27?g), or a non-carbohydrate placebo (nCho). Plasma endotoxin, I-FABP, TNF-α, IL-6, IL-1β, IL-10, and MCP-1 were measured pre-exercise, 20-min post-exercise, and again 2-h, and 4-h post-exercise. Results: Endotoxin increased 20-min post-exercise compared to pre in the Cho trial only (p?=?.03). I-FABP levels increased 20-min post-exercise in the Cho trial only compared to pre-exercise (p?=?.003). I-FABP levels were also increased in Cho trial 20-min post-exercise when compared to same time point in the nCho trial (p?=?.032). TNF-α increased 20-min post-exercise in the Cho trial only compared to pre (p?=?.03). Plasma IL-6 concentration increased 20-min post-exercise when compared to pre in both the Cho (p?=?.002) and nCho (p?=?.009), but remained elevated at the 2-h time point in the nCho trial (p?=?.03). I-FABP and several plasma cytokines (TNF-α, MCP-1, Il-6) returned to baseline sooner in the Cho trial. Conclusions: Ingestion of carbohydrate gel during exercise in the heat enhances markers of gastrointestinal wall damage.  相似文献   

Inherited Memories     

Vanita Sharma 《Cultural and Social History》2013,10(4):411-428

ABSTRACT

This article explores the creation and transmission of second generation memories concerning the 1947 Partition of British India. The research is based on oral interviews with Punjabi families who migrated because of Partition and now live in Lahore and Delhi. It explores how Partition memories have been transmitted across generations within these families, and also examines similarities and differences between how the second generation interviewees from Delhi and Lahore remember Partition. It demonstrates that the second generation have not passively accepted everything that the first generation, or the state, has told them about Partition. The second generation's memories are also shaped by their age, nationality, religion and class, and the nature of contemporary politics.  相似文献   

The impact of chronic carbohydrate manipulation on mucosal immunity in elite endurance athletes     

Alannah K. A. McKay  David B. Pyne  Peter Peeling  Avish P. Sharma  Megan L.R. Ross  Louise M. Burke 《Journal of sports sciences》2019,37(5):553-559

Carbohydrate (CHO) availability could alter mucosal immune responses to exercise. This study compared the effect of three dietary approaches to CHO availability on resting and post-exercise s-IgA levels. Elite race walkers (n = 26) adhered to a high CHO diet (HCHO), periodised CHO availability (PCHO) or a low CHO/high fat diet (LCHF) for 3 weeks while completing an intensified training program. HCHO and PCHO groups consumed 8.0–8.5 g.kg^?1 CHO daily, with timing of ingestion manipulated to alter CHO availability around key training sessions. The LCHF diet comprised 80% fat and restricted CHO to < 50 g.day^?1. A race walk test protocol (19 km females, 25 km males) was completed at baseline, after adaptation, and following CHO restoration. On each occasion, saliva samples were obtained pre- and post-exercise to quantify s-IgA levels. Resting s-IgA secretion rate substantially increased ~ two-fold post-intervention in all groups (HCHO: 2.2 ± 2.2, PCHO: 2.8 ± 3.2, LCHF: 1.6 ± 1.6; fold-change± 95% confidence limits), however, no substantial differences between dietary treatments were evident. Post-exercise, substantial 20–130% increases in s-IgA concentration and 43–64% reductions in flow rate occurred in all dietary treatments, with trivial differences evident between groups. It appears that high volume training overrides any effect of manipulating CHO availability on mucosal immunity in elite athletes.  相似文献