Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats     

Devendra K. Rai  Prashant Kumar Rai  Aradhna Gupta  Geeta Watal  Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201

Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides such as cartap (50% LD₅₀) and carbofuran (50% LD₅₀) as well as a combination of these two with 25% LD₅₀ of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein, total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses of carbofuran (50% LD₅₀) and cartap (50 % LD₅₀) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD₅₀ of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum lipids in rat.  相似文献   

Effect of ingestion of copper <Emphasis Type="Italic">bhasm</Emphasis> on red cell indices,iron parameters and essential elements in chicks     

D. C. Sharma  Bhawani Kochar  Ankita Bhardwaj  Manminder Riyat  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(3):245-249

In order to scientifically evaluate the effect of copper bhasm, it was orally administered in a dose of 2 mg/day for seven days to one month old male chicks. There was significant fall in total red cells, and rise in plasma iron, PCV and MCV indicating hemolysis, compensated by increased heme synthesis. A significant increase in plasma iron binding capacity points to beneficial effect of copper bhasm on liver as transferrin is synthesized in liver. Ferritin (storage iron) was unaltered in seven days treatment. The effect of copper bhasm on tissue distribution of essential elements was variable. Calcium, sodium and potassium were significantly increased in all the tissues. The last two may have been contributed by the bhasm itself. Magnesium behaviour was similar to calcium. Iron and zinc showed variable effects. Copper level in whole blood, plasma and erythrocytes increased significantly showing that copper bhasm was well absorbed and the effect observed can be ascribed to it. The bhasm was well tolerated and no growth retardation was seen.  相似文献   

Adaptive significance of circadian rhythms     

V. Sheeba  Vijay Kumar Sharma  Amitabh Joshi 《Resonance》1999,4(1):73-75

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Serum magnesium levels in preterm labour in relation to socioeconomic status     

Anjali Sharma  Simmi Kharb  Vineeta  Nirmal Gulati 《Indian journal of clinical biochemistry : IJCB》1998,13(2):123-125

The present study revealed significantly lower levels of serum magnesium in patients with preterm labour without any apparent cause as compared to normal term pregnant women in labour. The values were also lower in women with low socioeconomic status, older age and consuming vegetarian diet. Hence, estimation of serum magnesium levels in pregnancy may be a useful parameter in preterm labour.  相似文献   

Identification of drug-resistantMycobacterium tuberculosis by single strand conformation polymorphism and cleavase fragment length polymorphism     

Manju Sharma  Manuel Altamirano 《Indian journal of clinical biochemistry : IJCB》2000,15(2):88-93

Twenty isolates ofMycobacterium tuberculosis resistant to rifampicin(RIF), isoniazid(INH) and streptomycin(STR) were analysed by Polymerase Chain Reaction (PCR) amplification of rpoB, katG and rrs genes to evaluate comparative diagnostic significance of genetic assays. Mutations were identified by single strand conformation polymorphism (SSCP) and cleavase fragment length polymorphism (CFLP) and were confirmed by DNA sequencing. SSCP of 4 RIF resistant and 14 INH resistant isolates showed an extra peak at the level of 75-bp and 85-bp respectively, while 2 STR resistant isolates showed 2 peaks with 9 bases difference. CFLP showed a different pattern among RIF, INH and STR sensitive and resistant isolates Thus SSCP and CFLP can be used as alternative diagnostic methods for identification of mutations in RIF, INH and STR resistant strains of M.tuberculosis.  相似文献   

Breast and prostate cancer     

B. K. Sharma  A. Ray 《Indian journal of clinical biochemistry : IJCB》2000,15(1):110-117

There are interesting similarities between carcinomas of the breast and prostate. Both genetic and exogenous factors are probably important in the development of breast and prostate cancers. Since there is an alarming increasing trend in the incidence of both cancers worldwide including India, high level of apprehension/awareness has been created among the general educated population. Furthermore, both cancers are strongly linked with the expression of the c-erbB-2 oncogene which has been the focus of basic research in the recent past. This gene belongs to the family of growth factor receptors and it has important implication in diagnosis and future treatment modalities.  相似文献   

Role of Cultural Intelligence in Acculturation: Explorations on a Physiognomic Minority Diaspora in India     

Namrata Sharma 《Journal of Intercultural Communication Research》2019,48(3):274-291

The aim of this study was to analyse how cultural intelligence (CQ) influences the acculturation process and adaptive outcomes of a physiognomic minority indigenous cultural group in India. This study (N = 246) concerning the northeastern (NE) Indian diaspora in Indian cities outside the NE region. Path analysis showed that integration and assimilation predicted higher adaptation; while marginalization and separation lowered adaptation. Likewise, CQ positively predicted adaptation and also moderated the relationship between acculturation strategies and adaptation. Therefore, findings reflect the flexible facilitative role of CQ in promoting adaptation of minority groups in acculturation context.  相似文献   

Current Status and Future Directions for Cultural Intelligence     

Namrata Sharma 《Journal of Intercultural Communication Research》2017,46(1):96-110

The concept of cultural intelligence was formulated to ease and understand multicultural interactions in business organizations. Based on the theory of multiple intelligence; it is the cross-cultural facet of intelligence that assists adaptive cultural adjustment. Due to its implications for the contemporary world witnessing increased cultural contact and clashes; it has attracted multidisciplinary scholarly interest. This article reviews the development, validation and major approaches to the construct, along with a focus on its critical analysis. Significance of the construct in promoting intercultural discourse to encourage pacific multicultural existence is implicated. Furthermore, suggestions are made to extend the scope of cultural intelligence research and integrate it in diverse fields encompassing intercultural contact and communication.  相似文献   

The impact of early life trauma on health and disease: the hidden epidemic     

Dev Sharma 《Educational Psychology in Practice》2018,34(1):105-106

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Pre‐service teachers’ attitudes towards inclusion of students with high support needs in regular classrooms in Bangladesh          下载免费PDF全文

Tariq Ahsan  Umesh Sharma 《British Journal of Special Education》2018,45(1):81-97

In the process of educational reforms for promoting equity and inclusion in education, pre‐service teacher preparedness has been identified as a vital factor that has an impact on the success of inclusive education. Bangladesh, like other parts of the world, has taken various initiatives to promote inclusive education in the country context. This study is an attempt to explore factors related to pre‐service teachers’ preparedness for inclusive education in Bangladesh. The current study is an extension of the work completed in previous studies and specifically examined participants’ attitudes and factors that influenced their attitudes. Following a mixed method design, this multi‐phase study measured 1,623 pre‐service teachers’ attitudes towards inclusive education in phase 1. By applying a multiple regression procedure, several variables were identified that impacted on pre‐service teachers’ attitudes towards inclusion. The results indicated that Bangladeshi pre‐service teachers hold a less positive attitude towards the inclusion of children who have high support needs (that is, those who use Braille or sign language, or those who need to have an Individualised Academic Programme). In order to better understand the findings about apprehensive attitudes among pre‐service teachers, semi‐structured interviews were conducted with six institutional heads of pre‐service teacher education institutions. The interviews provided a new perspective on apprehensive attitudes among participants. Several curriculum reform suggestions are made that may have implications for policy‐makers and researchers in Bangladesh and beyond.  相似文献