Reactive oxygen species,reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2     

P. P. Singh  Farzana Mahadi  Ajanta Roy  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(4):324-342

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Effect of oral ingestion of different forms of silver on tissue content of some essential elements in chicks     

D. C. Sharma  Gora Dadheech  Bushra Fiza  Meghna Mathur  Manminder Riyat  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):202-204

Silver is ingested in India in the form of varak, Ayurvedic bhasm and water contained in silver utensils, but nobody knows their effects. We have examined the effect of interaction of silver ingested in the form of varak (leaf), bhasm (ash) and water (colloidal solution) on some essential elements (Na, K, Ca, Mg, Cu, Fe and Zn) in blood, liver, spleen and kidneys of chicks. The results showed significant rise of silver in all the tissues and significant fall in copper in the blood. The greatest rise was obtained in blood silver by silver sol while it had the lowest amount of silver. Iron significantly increased in tissues but somewhat decreased in blood. Zinc content increased in all the tissues by leaf and ash but decreased by sol. No consistent pattern was seen in case of other elements.  相似文献   

hs-CRP and oxidative stress in young CAD patients: A pilot study     

Suman B. Sharma  Seema Garg  Abhinav Veerwal  Sridhar Dwivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):334-336

Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40 years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde, antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians.  相似文献   

Preliminary studies on the detection ofMycobacterium avium-intracellulare complex using DNA probe from a clinical isolate     

P. Sharma  M. Bose  Isa Mohd  S. Bagdi  H. G. Raj 《Indian journal of clinical biochemistry : IJCB》2000,15(2):83-87

Genomic DNA from a clinical isolate ofMycobacterium avium-intracellulare complex was purified and cloned in PBR 322 at the tetracycline resistance site using Bam HI restriction enzyme. A 16 kb cloned fragment was purified, radiolabeled and used as a probe. Genomic DNA isolated from nineteen MAC strains, threeM. tuberculosis strains and oneM. kansasii strain were digested with Eco RI restriction enzyme, Southern blotted and hybridized with the 16 kb cloned and labeled fragment. Twelve MAC strains showed positive hybridization although five strains gave faint signals. Positive hybridization was noted in two out of the threeM. tuberculosis strains, possibly due to shared DNA homology. No signal was received from the singleM. kansasii strain used in this study.  相似文献   

The racialized surveillant assemblage: Islam and the fear of terrorism     

Sanjay Sharma  Jasbinder Nijjar 《Popular Communication》2018,16(1):72-85

ABSTRACT

Increasingly intense, multifaceted, and integrated forms of surveillance are a central feature of Western national security attempts to counter the violence of “Islamic terrorism.” However, there has been a lack of research examining contemporary regimes of surveillance as profoundly racialized. This study examines how counterterrorism efforts are underpinned by ill-conceived accounts of radicalization that preemptively construct Muslim migrants as a threat to national security, thereby justifying practices of mass surveillance that further propagate racist discourses of uncertainty and risk. We advance an analysis of a racialized surveillant assemblage, which is generative of mutable, algorithmically determined profiles of the Muslim-as-terrorist. Such a regime of mass surveillance effectively puts all Muslims under suspicion. We highlight that, paradoxically, mass data-mining operations stifle, rather than aid, the identification of actual terrorist threats. This conditions a paranoid surveillant racism, through which Muslim populations become modulated as an unknowable threat of death and destruction.  相似文献   

Carbohydrate gel ingestion during running in the heat on markers of gastrointestinal distress     

Jenna Sessions  Kelsey Bourbeau  Mattina Rosinski  Taylor Szczygiel  Rachael Nelson  Naveen Sharma 《European Journal of Sport Science》2016,16(8):1064-1072

The purpose of this study is to measure the effects of carbohydrate ingestion during exercise in the heat by measuring markers of gastrointestinal damage and inflammation. Methods: Active subjects (n?=?7) completed two 60-min running trials in a heated environment (70% VO₂max, 30°C). At minute 20 of exercise, subjects consumed a carbohydrate gel (Cho) (27?g), or a non-carbohydrate placebo (nCho). Plasma endotoxin, I-FABP, TNF-α, IL-6, IL-1β, IL-10, and MCP-1 were measured pre-exercise, 20-min post-exercise, and again 2-h, and 4-h post-exercise. Results: Endotoxin increased 20-min post-exercise compared to pre in the Cho trial only (p?=?.03). I-FABP levels increased 20-min post-exercise in the Cho trial only compared to pre-exercise (p?=?.003). I-FABP levels were also increased in Cho trial 20-min post-exercise when compared to same time point in the nCho trial (p?=?.032). TNF-α increased 20-min post-exercise in the Cho trial only compared to pre (p?=?.03). Plasma IL-6 concentration increased 20-min post-exercise when compared to pre in both the Cho (p?=?.002) and nCho (p?=?.009), but remained elevated at the 2-h time point in the nCho trial (p?=?.03). I-FABP and several plasma cytokines (TNF-α, MCP-1, Il-6) returned to baseline sooner in the Cho trial. Conclusions: Ingestion of carbohydrate gel during exercise in the heat enhances markers of gastrointestinal wall damage.  相似文献   

A concise guide to understanding suicide: epidemiology,pathophysiology and prevention     

Dev Sharma 《Educational Psychology in Practice》2015,31(2):211-212

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Development and validation of Mobile Learning Acceptance Measure     

Sujeet Kumar Sharma  Mohamed Sarrab  Hafedh Al-Shihi 《Interactive Learning Environments》2017,25(7):847-858

The growth of Smartphone usage, increased acceptance of electronic learning (E-learning), the availability of high reliability mobile networks and need for flexibility in learning have resulted in the growth of mobile learning (M-learning). This has led to a tremendous interest in the acceptance behaviors related to M-learning users among the information systems researchers. Despite a large amount of significant research in the field of M-learning, the measurement of user acceptance of M-learning has not received attention. This research study intends to develop and validate a survey that measures users’ acceptance of M-learning. A total sample of 806 university and higher college students from different institutes in Oman participated in this study. This research study was conducted in two stages. The first stage using a sample size of 388 students initiated a generic questionnaire, and examined factorial validity and reliability. The second stage that was conducted using different sample of 418 students employed confirmatory factor analysis to establish factorial validity and measurement invariance. A correlated six-factor model (Flexibility, Suitability, Enjoyment, Efficiency, Economic and Social) was fit using maximum likelihood estimation. The internal consistency and item reliability of Mobile Learning Acceptance Measure was found to be at acceptable level for both samples.  相似文献   

Exploring evidence of reflective thinking in student artifacts of blogging-mapping tool: a design-based research approach     

Ying Xie  Priya Sharma 《Instructional Science》2011,39(5):695-719

Reflective learning can assist a learner’s purposeful and conscious manipulation of ideas toward meaningful learning and knowledge integration. Blogs have been used to support reflection, but Blogs usually do not provide overt mechanisms for students to make connections between different parts of an experience, which is integral to reflective activity. A blogging-mapping tool was designed to support the reflective learning process. The tool allowed students to write blog posts, attach up to five keywords to each post, and link the keywords on a concept map. This study aimed to seek patterns of participants’ use of the tool, including evidence of reflective learning, identified as integration between concept maps and blogs. Nine graduate students participated in the study for a semester. Data analysis included examining concept maps for knowledge integration over time. Participants’ various mapping activities implied different levels of thinking. Some participants’ final concept maps showed signs that they tried to integrate knowledge around the content area. Yet, the inconsistent and inconclusive patterns of participants’ concept mapping activities signaled that more strategies were needed to sustain their commitment.  相似文献   

Aggravation of Inflammation by Smokeless Tobacco in Comparison of Smoked Tobacco     

Shailendra Dwivedi  Apul Goel  Sanjay Khattri  Praveen Sharma  Kamlesh Kumar Pant 《Indian journal of clinical biochemistry : IJCB》2015,30(1):117-119

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