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131.
132.
Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model 总被引:1,自引:1,他引:0
Dong-dong Deng Ying-lan Gong Guo-fa Shou Pei-feng Jiao Heng-gui Zhang Xue-song Ye Ling Xia 《Journal of Zhejiang University. Science. B》2012,13(9):676-694
In order to better understand biatrial conduction, investigate various conduction pathways, and compare the differences between isotropic and anisotropic conductions in human atria, we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial model. In addition to known pathways: (1) Bachmann’s bundle (BB), (2) limbus of fossa ovalis (LFO), and (3) coronary sinus (CS), we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis (CT), LFO, and CS. Our simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental data. The comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed, although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic conduction. In conclusion, we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working muscles. This study presents readers with new insights into human atrial conduction. 相似文献
133.
Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction 总被引:1,自引:0,他引:1
INTRODUCTIONInpatientswithcongestiveheartfailurespe-cificelectrocardiogram(ECG)alterations,suchaspathologicalQwavesorpersistentSTsegmentelevationsinMI-relatedleads,maybeseenaftertransmuralmyocardialinfarction(MI).Infarctex-pansionoccurswithinhoursofmyocyteinjury,resultsinwallthinningandventriculardilation,andcausestheelevationofdiastolicandsystolicwallstresses(Warrenetal.,1988).Ventricularremod-elingmaycontinueforweeksormonthsuntilthedistendingforcesarecounterbalancedbythetensilestren… 相似文献
134.
运动能促进身体组织和器官的有利改变,如运动调控骨骼肌的质量和力量变化。一方面,近期研究认为,细胞信号分子对骨骼肌卫星细胞的状态有决定性作用,如激活、增殖、分化、融合等促进骨骼肌重塑过程;另一方面,运动刺激骨骼肌中生长因子合成和分泌的变化,对骨骼肌细胞信号分子的传递与骨骼肌肥大密切相关。目前,国内外鲜有报道从运动和细胞信号分子交互作用探究运动促进骨骼肌肥大的机制。因此,研究试图对运动和多个细胞信号分子的交互作用进行综述,以期为人体复杂系统中骨骼肌肥大机制提供新的研究思路。 相似文献
135.
We observed in a pilot study that there was a transient elevation of brain natriuretic peptide (BNP) level shortly after the transplantation in the patient with ischemic heart failure, which is unexplainable by the simultaneous increase of the cardiac output and six-minute walk distance. Similar findings were observed in the phase I trial. We postulated on the basis of the finding of Fukuda in vitro that this transient elevation of BNP level against the improvement of cardiac function and exercise capacity might indicate cardiomyogenesis in patients after mesenchymal stem cell transplantation. Further study is warranted to verify the hypothesis. 相似文献