排序方式： 共有104条查询结果，搜索用时 15 毫秒
41.
Abdul Samad Aziz Madhav Govind Kalekar Adinath Narayan Suryakar Tabita Benjamin Milsee Jaya Prakashan Bijle Mohammed Nadeem Ahmed Mehmood Sayyad 《Indian journal of clinical biochemistry : IJCB》2013,28(4):374-380
The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein. The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers. 相似文献
42.
Michael J. Segel Jacob Luboshitz Dekel Shlomi Issahar Ben-Dov 《European Journal of Sport Science》2018,18(7):1022-1028
Local symptoms of chronic venous insufficiency after deep vein thrombosis (DVT) are well described, but little is known about the effect of residual venous obstruction on exercise capacity. We tested our hypothesis that chronic residual iliofemoral vein occlusion (IFVO) after DVT may impair exercise capacity. Nine post-DVT patients with residual IFVO and effort intolerance were studied; a comparison cohort consisted of 11 healthy volunteers. Exercise tolerance was assessed by bimodality incremental symptom-limited cardiopulmonary testing, using leg and arm ergometers. In healthy subjects, leg vein obstruction was modelled by application to the thighs of cuff tourniquets inflated to 30–40?mmHg. Leg exercise tolerance as measured by oxygen uptake at peak exercise (peak ?’O2) was reduced in patients (median 50% predicted (range 36–83%) vs. 88% predicted (67–129%) in normal subjects, p?2 was 0.95 (0.77–1.43) in patients vs. a normal ratio of 0.73 (0.6–1.0) in healthy subjects (p?2 in leg exercise to 76% predicted (range 55–108%; p?Chronic venous obstruction should be recognized as a cause of exercise limitation. 相似文献
43.
Mungli Prakash Jeevan K. Shetty Sambit Dash Bijay K. Barik Abhirup Sarkar Sharanabasappa M. Awanti Ravindra Prabhu 《Indian journal of clinical biochemistry : IJCB》2008,23(4):404-406
Total thiol status of plasma, especially thiol groups over protein contributes maximum to the plasma antioxidant status of
the body. Serum protein thiols were found to be decreased in various disease conditions including chronic renal failure patients.
Only few studies determined the levels of urinary protein thiols in disease conditions. The current study was designed to
know the levels of urinary protein thiols in patients with different grades of proteinuria. The study was conducted on urine
of 40 healthy controls and 61 cases with proteinuria. Based on proteinuria cases were further divided into two groups; group
I - microproteinuria (150–300 mg protein/d), 32 cases, group II - frank proteinuria (>300 mg protein/d), 29 cases. Urinary
thiol levels were determined by spectrophotometric method using dithionitrobenzoic acid. A significant decrease (p<0.01) in
urinary thiol in group I and group II cases was observed in present study and this decrease was associated with proteinuria. 相似文献
44.
目的:应用META分析技术定量评价慢性牙周炎与冠心病的联系。方法:检索中国期刊网、维普、万方数据等医学数据库,手工检索相关杂志并追查参考文献。独立筛选、评价文献和提取数据。对数据进行异质性检验后,借助Revm an4.2分析软件并根据其文献来源是否为同质总体而选择不同的M eta分析。结果:纳入6篇文献(794例病例)。冠心病组慢性牙周炎患病率为50.5%,而对照组仅为32.6%,两者差异有统计学意义(P<0.001)。单因素分析,慢性牙周炎与冠心病密切相关(OR=2.34,95%C I:1.16~4.73)。慢性牙周炎和冠心病不仅有统计学上的关联,还具有明显的剂量反应关系。结论:慢性牙周炎可能是冠心病的独立危险因素。 相似文献
45.
王建军 《黄冈职业技术学院学报》2012,(4):88-90
目的观察沙丁胺醇和丙酸氟替卡松雾化吸入治疗慢性阻塞性肺病急性加重的疗效。方法将29例慢性阻塞性肺疾病急性加重的患者随机分成两组,对照组28例,常规给予抗生素及相应对照治疗;实验组29例,在对照组的基础上沙丁胺醇与丙酸氟替卡松雾化吸入治疗。用药后观察实验组及对照组临床效应、不良反应及住院时间。结果实验组及对照组每组治疗前后1周临床症状评分差异有显著性,实验组FEV1/预计值,PEF/预计值及住院时间较对照组治疗差异有显著性,并且未发现不良反应。结论在常规抗炎、祛痰等治疗基础上加用沙丁胺醇和丙酸氟替卡松联合雾化治疗一周后,患者临床症状评分及肺功能均明显改善,明显缩短了治疗疗程和住院时间,且无严重不良反应。 相似文献
46.
40例慢性鼻窦炎功能性鼻内窥镜手术治疗临床观察 总被引：2，自引：0，他引：2
夏丽霞 《襄樊职业技术学院学报》2010,9(4):33-34
目的观察应用功能性鼻内窥镜手术治疗慢性鼻窦炎的临床疗效。方法 2006年6月至2008年8月利用鼻内窥镜手术治疗慢性鼻窦炎40例。结果 40例患者中治愈28例,好转12例,效果满意。结论功能性鼻内窥镜手术微创,可视,手术边界清,减少损伤,彻底清除病变,疗效确切。今后应在功能性鼻内镜手术过程中向微创、无创精细程度上发展。 相似文献
47.
Xinguo JIANG 《Journal of Zhejiang University. Science. B》2014,15(1):1-15
Standard treatment options for breast cancer include surgery, chemotherapy, radiation, and targeted therapies, such as adjuvant hormonal therapy and monoclonal antibodies. Recently, the recognition that chronic inflammation in the tumor microenvironment promotes tumor growth and survival during different stages of breast cancer development has led to the development of novel immunotherapies. Several immunotherapeutic strategies have been studied both preclinically and clinically and already have been shown to enhance the efficacy of conven- tional treatment modalities. Therefore, therapies targeting the immune system may represent a promising next-generation approach for the treatment of breast cancers. This review will discuss recent findings that elucidate the roles of suppressive immune cells and proinflammatory cytokines and chemokines in the tumor-promoting microen- vironment, and the most current immunotherapeutic strategies in breast cancer. 相似文献
48.
目的：探讨慢性阻塞性肺疾病（COPD）的综合治疗措施.方法：取60例住院的COPD患者病历资料,对患者临床表现、治疗措施、疗效等进行回顾性分析.结果：总有效率为95.0％,与治疗前比较,治疗后患者二氧化碳分压明显降低（P＜0.01）,氧气分压明显升高（P＜0.01）.结论：COPD发病原因复杂,在药物治疗基础上,采取心理指导、吸氧、护理和呼吸功能锻炼等综合措施可获得满意疗效. 相似文献
49.
Considering the convincing evidence that executive functions predict academic achievement significantly, strategies to foster executive functions in the early school years are highly requested. Besides traditional cognitive training, combined physical and cognitive interventions are intended to be a feasible way of enhancing both children’s daily physical activity and executive functions. The purpose of the present study was therefore to test the effectiveness of a six-week combined physical-cognitive intervention, and to compare it to both a sedentary cognitive intervention and a waitlist control group. Using a between-subjects experimental design, 189 children aged between four and six years (M = 5.34, SD = 0.59) were recruited from 14 kindergarten classes, which were randomly assigned to one of three experimental conditions: (a) combined physical and cognitive training, (b) sedentary cognitive training or (c) waitlist control group. Before and after the interventions, all three core executive functions of updating, inhibition and shifting were measured. Physical activity was objectively measured using accelerometers during one intervention session. Linear mixed models revealed that children from both the combined physical-cognitive and the sedentary cognitive intervention improved their updating performance compared to the children of the control group. Inhibition and shifting remained unaffected by both interventions. With respect to children’s daily physical activity, linear mixed models showed that only the combined physical-cognitive intervention could significantly increase the amount of step counts. The results underline the feasibility of combined physical-cognitive interventions to enhance children’s daily physical activity and their cognitive performance. 相似文献
50.
K. Sri Manjari Pratibha Nallari A. Vidyasagar A. Jyothy A. Venkateshwari 《Indian journal of clinical biochemistry : IJCB》2012,27(2):152-156
Chronic pancreatitis (CP) presenting clinically with upper abdominal pain, as well as exocrine and endocrine insufficiencies, is characterized by irreversible morphological and functional alterations in the pancreas. The objective of the present study is to investigate the plasma levels of transforming growth factor-β 1 (TGF-β1), matrix metalloproteinases MMP-1 (collagenase) and MMP-3 (stromelysin) in CP. A total of 71 CP patients and 100 control subjects were considered for the study. Plasma levels of TGF-β1, MMP-1 and MMP-3 were determined by enzyme-linked immunosorbent assay in patients and control subjects. The plasma levels of TGF-β1 and MMP-1 were significantly elevated in patients compared to control group (*P = 0.0301, **P < 0.0001). However, there was no significant difference in the plasma levels of MMP-3 between patients and controls (P = 0.3756). The elevated levels of TGF-β1 and MMP-1 may influence the inflammatory reactions by enhancing the pancreatic stellate cell activation and deposition of extracellular matrix resulting in pancreatic fibrosis. Thus, the present study highlights the role of fibrogenic cytokine marker TGF-β1 and matrix metalloproteinases in the pathogenesis of CP. 相似文献