排序方式： 共有104条查询结果，搜索用时 31 毫秒
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慢性肾脏疾病是复杂的威胁公共健康的疾病。慢性肾病与高致死率、高发病率、高治疗费用相关。肾脏纤维化是肾脏慢性病变的病理形态表现,是指在各种致病因子如炎性因子,机械性损伤,药物等导致的细胞外基质（extracellarmatrix。ECM）合成增多降解减少,肾小球基底膜增厚,最终影响肾脏功能。目前关于慢性肾病的研究重要集中在药物筛选方面,而运动是否能改善慢性肾脏疾病的研究较少。本文通过文献资料法与逻辑推理相结合的方法总结运动与慢性肾脏疾病的研究,总结指出：1适当的运动通过减弱肾脏病变引起的纤维化程度,改善慢性肾脏疾病。2运动可以通过调解TGF-β1／Smad信号通路改善慢性肾脏疾病 相似文献
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目的观察电生理检测对慢性乙醇中毒的诊断价值。方法对32例慢性乙醇中毒患者的临床特征进行分析,并作神经电图（NCV）肌电图（EMG）检测进行分析。结果32例慢性乙醇中毒患者的EMG检查经综合判断提示神经源性损害;MCV异常率为65.6％,≥SCU异常率为83．3％．结论EMG,NCV能反映慢性乙醇中毒引起的周围神经系统的弥漫性损害,为临床提供电生理检测的客观指标。 相似文献
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CFS的诊治及其运动处方的应用 总被引：4，自引：0，他引：4
查阅了近十几年的HIGHWIRE和MEDLINE上有关慢性疲劳综合症预后的文献,进行了系统的综述,介绍了慢性疲劳综合症(CFS)的诊断标准及病理机制,同时对各疗法效果进行了比较.结果表明,科学的制定运动处方,采用"阶梯运动疗法"能有效改善患者疲劳程度,减轻并发症状,提高运动能力.同时没有任何副作用.建议采用"阶梯运动疗法"治疗CFS,并对运动疗法处方的构成进行了归纳. 相似文献
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Pragna Rao G. C. Reddy A. S. Kanagasabapathy 《Indian journal of clinical biochemistry : IJCB》2008,23(3):209-217
Chronic kidney disease is becoming a major health problem globally and in India an alarming number of about 8 million people
are suffering from this disease. Patients undergoing hemodialysis have a high prevalence of protein-energy malnutrition and
inflammation. As these two conditions often occur concomitantly in hemodialysis patients, they have been referred together
as ‘malnutrition-inflammation-atherosclerosis syndrome’ to emphasize the important association with atherosclerotic cardiovascular
disease. The three factors related to the pathophysiology in these patients are dialysis related nutrient loss, increased
protein catabolism and hypoalbuminemia. Inflammation in Chronic Kidney disease is the most important factor in the genesis
of several complications in renal disease. Pro-inflammatory cytokines like IL-1 and TNF-alpha play a major role in the onset
of metabolic alterations in Chronic Kidney disease patients. Atherosclerosis is a very frequent complication in uremia due
to the coexistence of hypertension, hyperhomocysteinemia, inflammation, malnutrition and increased oxidative stress, generation
of advanced glycation end products, advanced oxidation protein products, hyperlipidemia and altered structural and functional
ability of HDL. LDL-cholesterol, apolipoprotein (A), apolipoprotein (B), and Lp(a) are also associated with atherosclerosis.
Studies have now provided enormous data to enable the evaluation of the severity of malnutrition-inflammation-atherosclerosis
syndrome as well as effective monitoring of these patients. 相似文献
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Rizwan Ahmad Anil K. Tripathi Payal Tripathi Ranjana Singh Sushma Singh Raj K. Singh 《Indian journal of clinical biochemistry : IJCB》2008,23(4):328-333
Chronic myeloid leukemia is a myeloproliferative disorder with a unique rearrangement, the Philadelphia chromosome. Oxidative
stress, a pervasive condition of an increased number of reactive oxygen species, is now recognized to be prominent feature
of various diseases and their progression. Thus antioxidants, which control the oxidative stress state, represent a major
line of defense regulating overall true state of health. The relationship between antioxidants status and levels of well-known
markers of oxidative stress that are measured as lipid peroxides and oxidized proteins reflect better health indices and postures.
The aim of this study was to evaluate the role of oxidative stress in pathophysiology of Chronic myeloid leukemia by measuring
the circulating plasma lipid peroxide levels in terms of malonyldialdehyde, total lipid hydroperoxide and oxidized proteins
as protein carbonyl whereas antioxidant status were estimated in terms of reduced glutathione and total thiol in plasma of
Chronic myeloid leukemia patients. The present study included 47 Chronic myeloid leukemia patients and 20 age-and sex-matched
healthy subjects. Out of 47 Chronic myeloid leukemia patients, 31 were in chronic phase (CML-CP) and 16 in accelerated phase
(CML-AP). The median age of Chronic myeloid leukemia patients was 33 years and that of controls was 32 years. Oxidative stress
and antioxidant status in plasma were evaluated by spectrophotometric procedures. There was a significant increase (p<0.05)
in plasma malonyldialdehyde, total lipid hydroperoxide and protein carbonyl levels in Chronic myeloid leukemia patients as
compared to healthy subjects. Our results also showed that plasma malonyldialdehyde and protein carbonyl levels were markedly
elevated (p<0.05) in both chronic phase (CML-CP) and accelerated phase (CML-AP) as compared to healthy volunteers. Antioxidant
status was found to be significantly decreased (p<0.05) in Chronic myeloid leukemia patients and its phases as compared to
healthy participants. It could be concluded that oxidative stress may be associated with the pathophysiology of Chronic myeloid
leukemia. 相似文献
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[目的]了解甘草酸苷对慢性乙肝患者血糖的影响.[方法]把95例确诊为慢性乙型肝炎的患者随机分为A、B、C三组,分别给予复方甘草酸苷80 m l、复方甘草酸单铵120 m l、甘草酸二铵40 m l静脉点滴,用药前、用药2周及4周观察三组患者的空腹血糖、肝功能、HBVM、HBV-DNA定量.[结果]治疗前三组患者空腹血糖的均数分别为5.28±1.75、5.32±1.66及5.65±1.82 mmol/L,在用药2周时,三组患者空腹血糖的均数即已有所下降,至用药4周其空腹血糖的均数分别为4.5 1±1.6 5、4.6 8±1.3 7及4.9 8±1.87 mmol/L,与治疗前相比三组患者空腹血糖的均数都有不同程度下降,但治疗前后的差异无显著性(P>0.05),各组之间下降的差异亦无显著性(P>0.05).[结论]甘草酸苷对慢性乙肝患者的血糖没有升高作用,反而在一定剂量下有降低的作用. 相似文献
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Rebecca Abraham Rinchu Loomba Jeyaraj D. Pandian 《Indian journal of clinical biochemistry : IJCB》2002,17(2):64-67
We present 2 cases of lead poisoning, the first of a child playing with painted toys and the second of an adult on local medicine.
The former presented with acute abdomen and the latter with peripheral muscle weakness. We propose that raised serum δ-amino
leavulinic acid (δ-ALA) levels strongly point towards the possibility of lead poisoning. 相似文献
100.
目的:探讨慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机的临床护理方法及其疗效。方法:随机选择2012年1月~2014年2月广西中医药大学第一附属医院收治的100例慢性阻塞性肺疾病合并呼吸衰竭使用无创呼吸机进行治疗的患者,将所有患者随机分为研究组与对照组,每组50例患者。研究组患者给予舒适护理治疗,对照组患者给予常规护理治疗,分析两组的最终护理效果。结果:研究组患者在治疗积极配合率、并发症发生率以及不良情绪发生率上明显优于对照组,研究组患者的PaO2、PH与对照组对比,都明显高于对照组,PaCO2明显低于对照组,两组对比差异有统计学意义(P0.05)。结论:对慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机患者给予舒适护理治疗,可有效改善症状,提高临床疗效,值得推广。 相似文献