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61.
刘俊杰 《聊城师范学院学报》2006,(6):96-97,95
《终成眷属》的表层存在“爱情与偏见”的冲突。但从结构、情感两个层面分析后，我们可以从表层的冲突中发现伊瑟尔的“召唤结构”，这给我们提供了另一种审美空间，有助于更好地理解作品的主题。 相似文献
62.
When navigating through the vast amount of information that we encounter in our everyday lives, we constantly make decisions concerning what information to read more closely and what information to disregard. Consideration of the relevance and trustworthiness of information sources facilitates those decisions. In the present study, we interviewed 25 upper-secondary students after they had selected documents to use in completing a task, and we asked them to justify their selections. A qualitative analysis of the interview data showed that students’ justifications could be related to (1) content relevance, (2) source features, and (3) prior topic knowledge. The results demonstrate that students are able to evaluate content relevance and source features as part of their document selection strategies but that perceived prior knowledge seems to influence both selections and justifications. 相似文献
63.
多发性骨髓瘤被认为是一种无法治愈的血液系统恶性疾病,其特征为恶性浆细胞的克隆性增殖。尽管在过去的几十年中,自体干细胞移植(ASCT)的应用及新型药物(蛋白酶体抑制剂和免疫调节药)的问世,将患者的中位生存时间由原来的4年提高到了8年,但复发与难治仍然是多发性骨髓瘤疾病进程中难以逾越的鸿沟。为了获得长期持续的缓解,免疫治疗开始在多发性骨髓瘤中崭露头角,其中嵌合抗原受体(CAR)T细胞治疗就是最有潜力的一颗新星。通过在基因层面改造患者自己的T细胞,使T细胞表达一种特定的受体(人造的融合蛋白),该受体可以识别并结合肿瘤相关抗原,并活化T细胞启动后续的杀伤过程。Tisagenlecleucel和Axicabtagene是两个针对CD19抗原的CAR T产品,用于治疗B细胞来源的急性淋巴细胞白血病(B-ALL)和弥漫大B细胞淋巴瘤(DLBCL),并于2017年被美国食品药品监督管理局(FDA)批准。这两个产品的发展极大推动了B细胞来源的恶性血液系统疾病的治疗,并刷新了对于传统治疗的认知。基于之前CAR T治疗的成功经验,寻找如CD19一样的特定靶点能为CAR T治疗多发性骨髓瘤打下基础。本综述介绍了数个在骨髓瘤细胞上的肿瘤靶抗原,如B细胞成熟抗原(BCMA)和CD38。这些针对抗原的CAR T治疗有些还在实验室阶段,而有些已经进入了3期的临床试验,很有可能成为下一个被批准的CAR T产品。另外,本综述也介绍了在CAR T治疗中出现的毒副反应以及相应的管理和处理方法。 相似文献
64.
This study examined the role of context effects in the processing of homophones in Chinese and Chinese-English bilingual speech. In Experiment 1, Chinese speakers were presented with successively gated portions of a homophone in a sentence context, and they identified the homophone on the basis of its increasing acoustic information. In Experiment 2, Chinese-English bilinguals were presented with a cross-language homophone in a sentence context, and they named a visual probe that had or did not have phonological overlaps with the homophone. Results indicate that prior sentence context has an early effect on the disambiguation of various homophone meanings, shortly after the acoustic onset of the word, in both monolingual and bilingual situations. The results are accounted for by interactive activation models of lexical processing, in which the recognition of a homophone is a result of the interactions among phonological, lexical, and contextual information at an early stage. 相似文献
65.
66.
采用云南省香格里拉气象站55a（1958-2012）的逐年气温、降水量、绝对湿度、相对湿度和霜日数资料,引入多元最小二乘估计模型（多元OLS）、多元向量自回归模型（多元VAR）和结构方程模型,基于Morlet连续复小波（Cmor）变换的主周期数据,探索未来50a香格里拉气温等气候环境要素的定量预估模型、变化趋势及5个主要气候环境要素的相互关系。结果表明：未来50a内香格里拉的气温以0.44℃/10a的速率升高,50a后气温将升高2℃左右;降水以围绕平均值做周期振荡为主,并以14.7mm/10a的速率增多;绝对湿度以0.06 mg/L/10a的速率增大,并有明显的周期振荡;相对湿度以-0.96%/10a的速率减小,并有周期振荡;年霜日数以-2.8d/10a的速率减少,并有周期振荡。绝对湿度、相对湿度和霜日数的变化与气温和降水的变化显著相关,气温变化对湿度和霜日数的影响大于降水量的影响,气温的持续升高是除降水外其他气候要素变化的主要原因。 相似文献
67.
68.
Access to scholarly information in the disciplines of education and medicine occurred primarily through the simultaneous development of two bibliographic databases. The Education Resource Information Center (ERIC) originated as a resource designed to be comprehensive in its inclusion of peer-reviewed and unpublished literature for the entire education community. MEDLINE began as a resource of selective materials for physicians and researchers. Today, ERIC includes selected peer-reviewed literature directed primarily to researchers and practitioners, although others use the database, while MEDLINE is a vast information system serving all health professionals and consumers. This literature analysis of their policy history shows important differences in their evolution. Application of the Multiple Streams Framework can help in formulating possible explanations for the different developmental paths. These paths include: the degree of centralization or decentralization of the information system's organizational structure; the stability of the organizational mission; and the success of assessment strategies, federal budgetary support, and bias toward science in federal policy-making. These two government-supported databases served as models for a plethora of other databases. However, one was successful in acquiring funding from the outset, while the other continually suffered deficiencies in support. The importance of each to public welfare should have been obvious, but was not. 相似文献
69.
热娜·买买提 《和田师范专科学校学报》2010,29(1):118-119
这篇文章主要分析在我国大学的非英语专业的英语教学中多无智能理论是被如何运用的。这里只涉及到了八种智力理论中的五种。这篇文章探讨了如何针对学生不同智力情况,灵活运用多元智能理论。这篇文章的目的在于向我国的教授大学英语的教师展示如何把这个理论运用到教授非英语专业教学当中,从而提高教学质量。 相似文献
70.
多源流分析框架是美国政策家约翰.W.金登提出的一种政策分析方法,他认为整个系统中存在着三股源流,即问题流、政策流和政治流,而＂政策之窗＂对三者起了耦合作用。推动1999年我国高等教育扩招政策出台的＂问题流＂主要是1997年亚洲金融危机,＂政策流＂是著名学者对发展高等教育的理论探索,＂政治流＂是我党对教育公平的关注,＂政策之窗＂便是金融危机的爆发以及汤敏夫妇的建议。扩招政策的出台促进了教育公平,推动了高等教育的发展,但是与之同时,也带来了一系列问题。各部门要采取有力措施,更加关注效益和质量。 相似文献