血管内皮功能紊乱与运动对血管内皮功能的调节   总被引：2，自引：0，他引：2  

张昆茹 《成都体育学院学报》2006,32(5):93-96

血管内皮功能紊乱主要原因是血管内皮一氧化氮(NO)的释放量减少而失去了NO的血管保护作用。研究表明,血管内皮功能紊乱和动脉粥样硬化、高血压、糖尿病的发生发展密切相关,患高血压大鼠、肥胖大鼠、糖尿病大鼠,都有不同程度的血管内皮功能紊乱。运动可以改善血管内皮功能。  相似文献   

长时间不同负荷运动对大鼠神经内分泌免疫功能的影响   总被引：9，自引：0，他引：9  

李红武  陈佩杰  徐锋鹏 《上海体育学院学报》2002,26(1):38-42

采用分组实验的方法，研究长时间不同负荷的游泳训练对大鼠免疫系统功能和内分泌系统反应的影响。结果显示，S组大鼠脾细胞对ConA和LPS刺激的应答能力下降；S组与C组大鼠的下丘脑、垂体、血浆中的β—EP、D=mA113、AVID、OT存在显著差异；S组大鼠血浆中GC的浓度上升；胸腺细胞中GR显著降低。而C组和M组大鼠相比较，各指标无变化。由此可知，不同负荷训练导致大鼠免疫系统功能和神经内分泌系统功能发生不同的变化．两系统间内在的相关机制尚需进一步研究。  相似文献   

运动性贫血时大鼠红细胞锌卟啉、转铁蛋白受体及营养干预的影响   总被引：3，自引：2，他引：1  

曹建民  金丽  赵杰修  郑弘溶  田野 《北京体育大学学报》2004,27(4):477-479

红细胞锌卟啉、红细胞膜转铁蛋白受体是反映铁贮备的指标,实验结果表明:运动训练导致运动性贫血大鼠红细胞锌原卟啉含量和红细胞膜转铁蛋白受体含量明显增加,且与血清铁呈高度相关,说明红细胞锌卟啉是反映缺铁性贫血的良好指标,而红细胞膜转铁蛋白受体含量能更为准确地反映红细胞内和机体铁代谢状况;抗贫血铁制剂复合营养补剂的干预显著降低了运动性贫血大鼠红细胞锌原卟啉和红细胞膜转铁蛋白受体含量,并通过对这些机体铁代谢状况指标的改善反映抗贫血铁制剂复合营养补剂对提高大鼠红细胞铁贮备和维持大鼠铁代谢稳定具有积极作用.  相似文献   

生物控制论在人体功能调节中的作用     

张海潮 《山西师大体育学院学报》1995,(1)

生物控制论是控制论的一门应用科学,从50年代产生并逐渐发展起来。它对人体功能调节机制初步。建立了理论体系,加之,生命过程本身就是一个控制过程。本文通过具体实例阐述了生物控制论在人体功能调节中的作用,进一步扩大其应用范围,促进体系的完善和发展。  相似文献   

Physical Activity Indicators,Metabolic Biomarkers,and Comorbidity in Type 2 Diabetes     

《Research quarterly for exercise and sport》2012,83(4):690-698

ABSTRACT

Purpose: This study aimed (1) to compare physical activity (PA) indicators, metabolic biomarkers, and comorbidity, (2) to investigate the relationship between PA indicators and metabolic biomarkers, comorbidity and (3) to identify barriers to PA in patients with type 2 diabetes (T2DM) who are using oral hypoglycaemic agent (OHA) or combined OHA and insulin (OHAiN). Methods: Sixty-one patients were classified as patients using only OHA or combined OHAiN. Metabolic biomarkers (waist-to-hip ratio, body mass index (BMI), lipid profile, glycosylated haemoglobin (HbA1c), fasting blood glucose, comorbidity and PA indicators (self-reported PA, number of steps (NOS), 6-minute walking distance (6MWD)) were assessed. PA perceptions and reasons for inactivity were questioned. Results: The comorbidity (p = .013), low-density lipoprotein-cholesterol (p = .026), total cholesterol (p = .008) and HbA1c (p = .020) were higher and PA level was lower (p = .007) in the OHAiN group. NOS was positively correlated with high-density lipoprotein-cholesterol (p = .037) and negatively correlated with BMI (p = .007). 6MWD was negatively correlated with BMI (p = .014) and comorbidity (p = .004) in the OHA group. BMI was a significant predictor of NOS (adjusted R² = 0.242) and comorbidity for 6MWD (adjusted R² = 0.250) in the OHA group. The majority of the patients (OHA = 34.3%, OHAiN = 42.3%) reported “lack of time” as the most common barrier to PA. Conclusions: This study showed that patients on OHAiN have lower PA levels, poorer metabolic profiles, and higher comorbidity rates than OHA users. PA indicators were related with some metabolic biomarkers and comorbidity in only OHA users. The most common reason for inactivity was “the lack of time” in both groups.  相似文献   

Arachnoid cell involvement in the mechanism of coagulation-initiated inflammation in the subarachnoid space after subarachnoid hemorrhage     

Zhao-liang Xin  Xiao-kang Wu  Jian-rong Xu  Xi Li 《Journal of Zhejiang University. Science. B》2010,11(7):516-523

Objective: To assess if arachnoid cells have the capability to present antigen and activate T-lymphocytes after stimulation by bloody cerebrospinal fluid (CSF), and to illuminate the mechanism of coagulation-initiated inflammation in the subarachnoid space after subarachnoid hemorrhage (SAH). Methods: Arachnoid cells were cultured, characterized, and examined by immunofluorescence for the basal expression of human leukocyte antigen-DR (HLA-DR). Expression of HLA-DR, after co-culturing arachnoid cells in vitro with bloody CSF, was investigated by immunofluorescence and flow cytometry (FCM). The variation of arachnoid cells' ultrastructure was observed by transmission electron microscope (TEM). Arachnoid cells were co-cultured with peripheral blood mononuclear cells (PBMCs). The content of soluble interleukin-2 receptor (sIL-2r) in culture medium was detected by enzyme-linked immunosorbent assay (ELISA). Results: (1) Arachnoid cells were successfully cultured for many passages. The immunofluorescent staining was positive for HLA-DR in over 95% of the human arachnoid cells. The punctate HLA-DR was distributed in cytoplasm and not in the karyon. (2) After co-culturing arachnoid cells in vitro with bloody CSF, numerous particles with strong fluorescence appeared in the cytoplasm on Day 6. On Day 8, the quantity of particles and fluorescent intensity were maximal. FCM showed that the percentage of HLA-DR expressing cells was (2.5±0.4)% at the first 5 d, increasing to (60.8±3.6)% on Day 7. (3) After co-culturing arachnoid cells in vitro with bloody CSF, many lysosome and secondary lysosome particles were present in the cytoplasm. Hyperplasia of rough endoplasmic reticulum and enlarged cysts were observed, with numerous phagocytizing vesicles also observed at the edge of the arachnoid cells. (4) Arachnoid cells stimulated by bloody CSF were co-cultured in vitro with PBMCs. The content of sIL-2r in the culture medium, having been maintained at around 1.30 ng/ml during the first 3 d, had increased by Day 4. The content of sIL-2r peaked 7.53 ng/ml on Day 7 and then reduced gradually. Conclusions: (1) Basic HLA-DR expression is present in arachnoid cells. (2) After stimulation by bloody CSF, arachnoid cells have the potential to serve as antigen presenting cells (APCs) and the ability to activate T-lymphocytes, indicating that arachnoid cells are involved in the mechanism of coagulation-initiated inflammation in the subarachnoid space after SAH.  相似文献   

Characteristics of transgenic tomatoes antisensed for the ethylene receptor genes LeERT1 and LeERT2     

Wang ZF  Ying TJ  Zhang Y  Bao BL  Huang XD 《Journal of Zhejiang University. Science. B》2006,7(7):591-595

Two stable transformed lines containing antisense LeERT1 or LeERT2 sequences and their hybridized line were investigated to determine the effect of LeERT1 and LeERT2 specificity in the ethylene receptor family in tomato （Lycopersicon esculenturn Mill.） on ethylene signaling. The transgenic line alel containing antisense LeER T1 displayed shorter length of seedling grown in the dark and adult plant in the light, severe epinastic petiole, and accelerated abscission of petiole explant and senescence of flower explant, compared with its wild type B 1. The transgenic line ale2 containing antisense LeERT2 also exhibited shorter hypocotyls and slightly accelerated abscission. The phenotypes of cross line dale of LeERT1 and LeERT2 were close to alel in many aspects. These results suggested that LeERT1 probably plays a relatively important role in ethylene signaling of tomato growth and development.  相似文献   

X25165与AT89C51在智能监控系统中的应用     

龚德良 《衡阳师范学院学报》2001,22(6):50-53

从X25165芯片的结构、性能、工作原理出发，研究了X25165与AT89C51组成的智能监控系统的结构特点和工作原理。  相似文献   

妊娠期糖尿病相关炎性因子的研究进展     

何可人  单莉莉  刘芳  王珊 《深圳职业技术学院学报》2021,(1)

目前妊娠期糖尿病的发病机制尚不完全清楚,随着研究的进展,免疫炎症假说日益受到学者的重视.妊娠期糖尿病的发病与病人体内的促炎/抗炎细胞因子平衡失常有关,该平衡倾向于促炎细胞因子的分泌,而抗炎细胞因子在疾病的发生、发展中可能发挥保护作用,文章综述了促炎细胞因子(TNF-6、IL-6、IFN-γ、IL-2、IL-17、IL-1β)和抗炎细胞因子(IL-10、IL-37、IL-4)在妊娠期糖尿病发生、发展中的作用,以及它们在临床筛查和诊断中的应用,以期为妊娠期糖尿病的预测和防治提供参考.  相似文献   

TGF-β1 treated murine dendritic cells are maturation resistant and down-regulate Toll-like receptor 4 expression     

牟海波  林茂芳  岑洪  俞静  孟筱坚 《浙江大学学报(A卷英文版)》2004,5(10):1239-1244

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