中药寒热相关药性和抑制脂肪酸合酶能力关系的探索     

马晓丰  刘杨  张三国  陈传楚  田维熙 《中国科学院大学学报》2012,29(5):699-706

测定了药典中106味温热性中药和119味寒凉性中药对脂肪酸合酶的抑制水平,发现温热药中对该酶强抑制的频数高于寒凉药约38%. 进一步分析发现,温热药中的温里和散内寒药中强抑制药的频数大幅提高,而寒凉药中的清热泻火、明目、清虚热药中强抑制药的频数则进一步降低,差异均具有显著性. 综合以上结果提出,直接影响能量代谢系统、造成能量代谢率变化是形成中药的寒热药性的因素之一.  相似文献   

Increased dietary carbohydrate and endurance during single‐leg cycling using a limb with normal muscle glycogen concentration     

A.E. Hardman  C. Williams 《Journal of sports sciences》2013,31(2):127-138

The purpose of this study was to test the hypothesis that increased availability of blood‐borne glucose would improve endurance after carbohydrate loading. A single‐leg exercise model was employed, taking advantage of the fact that supercompensation of muscle glycogen occurs only in a previously exercised limb. Endurance time to exhaustion at 70% of maximal oxygen uptake (VO₂max) was determined for 11 males and three females who were then allocated to a control group or a high‐carbohydrate (CHO) group. For 3 days following Test 1 the control group maintained a prescribed normal diet whilst the CHO group increased the proportion of energy derived from carbohydrate (62.1 ± 4.3% cf. 43.9 ± 2.0%, P < 0.01). The endurance test was then repeated using the leg that was inactive during Test 1. Endurance time was increased on Test 2 (123.7 ± 43.2 min cf. 98.5 ± 21.9 min, P <0.05 one‐tailed test) for the CHO group but not for the control group (101.8 ± 21.7 min cf. 107.5 ± 9.1 min, NS). There was no indication of enhanced carbohydrate metabolism during Test 2 for the CHO group but mean heart rate was lower during Test 2 than during Test 1 (145 ± 14 beat min ^‐1 cf. 152 ± 12 beat min ^‐1, P<0.05). These results suggest that the prior consumption of a high‐carbohydrate diet improves endurance during high‐intensity cycling with a limb with normal muscle glycogen concentration.  相似文献   

Efficacy of Tumor Necrosis Factor and Interleukin-10 Analysis in the Follow-up of Nonalcoholic Fatty Liver Disease Progression     

Walid E. Zahran  Kholoud A. Salah El-Dien  Philip G. Kamel  Ahmed Shawky El-Sawaby 《Indian journal of clinical biochemistry : IJCB》2013,28(2):141-146

Tumor necrosis factor (TNF-α) is a cytokine involved in systemic inflammation during acute phase reactions. The current study was designed to investigate the levels of pro-inflammatory cytokine (TNF-α) along with the anti-inflammatory cytokine (IL-10) during progression of non-alcoholic fatty liver disease (NAFLD) from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis in diabetic patients, and correlate the levels of cytokines with the progression of NAFLD. Fifty-two diabetic patients compared to 18 healthy controls were participated in this study. Based on clinical diagnosis, patients were divided into three groups: simple steatosis, NASH and fibrosis. Serum liver function tests, fasting blood glucose, bilirubin, ALT, AST, TNF-α, IL-10 and lipid profile were measured. TNF-α levels were significantly higher in NAFLD patients compared to control subjects with a significant positive correlation with body mass index and fasting blood glucose (FBG) but with negative correlation with IL-10. Serum IL-10 levels were significantly lower in NAFLD patients compared with controls. A positive correlation between IL-10 and HDL-C with concomitant negative correlation between IL-10 and FBG and triacylglycerides was found. Cytokine analyses showed that there was a prominent imbalance between TNF-α and IL-10 in patients with NAFLD, and this imbalance increase by increasing the progression of NAFLD especially in obese diabetic patients. TNF-α and IL-10 could be used in diagnosis and follow-up of NAFLD stages in a way to avoid liver biopsies in greater proportion of patients.  相似文献   

Dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans   总被引：2，自引：0，他引：2  

Weng XC  Zhou L  Fu YY  Zhu SM  He HL  Wu J 《Journal of Zhejiang University. Science. B》2005,6(9):869-872

INTRODUCTION Rocuronium bromide is a new steroidal nonde- polarizing neuromuscular blocking drug that has a faster onset of action than other nondepolarizing neuromuscular blocking drugs. The liver is the major route for its elimination. On the other hand, impaired liver function does not alter either atracurium’s elimination or plasma clearance (Ward and Neill, 1983; Pitter et al., 1990). The exclusion of the hepatic circulation and function during the anhepatic phase of orthotopic liv…  相似文献   

高校新生体检异常情况的应对及护理干预     

栗书艳 《晋城职业技术学院学报》2020,13(2):24-26

鉴于大学生体检过程中存在的抽血晕针、肝功能异常和高血压等常见问题,结合笔者多年从业经验,从相应的心理、体质、环境等角度提出了一些切实可行的方法,进行针对性护理干预,建立学生健康档案,从而更好地为学生服务。  相似文献   

野鸦椿果实水提物对急性酒精性肝损伤的保护作用     

钟飞  高辉 《怀化师专学报》2012,(2):29-31

40只雄性SD大鼠随机分成5组,分别是正常组、模型组和野鸦椿高、中、低剂量,采用50%乙醇灌胃造模,同时给相应剂量野鸦椿水提物,给药一周后检测大鼠血清AST、ALT、TBIL、DBIL以及TG含量,并取肝组织HE染色进行病理学检.通过以上处理后,野鸦椿水提物各剂量组大鼠血清AST、ALT、TBIL、DBIL及TG均不同程度的下降,病理组织学检查给药组肝组织病理损害也较模型组轻;以上结果说明野鸦椿水提物对大鼠急性酒精性肝损伤具有保护作用.  相似文献   

Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats     

Fabrice Tranchida  Léopold Tchiakpe  Zo Rakotoniaina  Valérie Deyris  Olivier Ravion  Abel Hiol 《Journal of Zhejiang University. Science. B》2012,13(4):307-317

As the consumption of fructose and saturated fatty acids (FAs) has greatly increased in western diets and is linked with an increased risk of metabolic syndrome, the aim of this study was to investigate the effects of a moderate (10 weeks) and a prolonged (30 weeks) high fructose and saturated fatty acid (HFS) diet on plasma FA composition in rats. The effects of a few weeks of HFS diet had already been described, but in this paper we tried to establish whether these effects persist or if they are modified after 10 or 30 weeks. We hypothesized that the plasma FA profile would be altered between 10 and 30 weeks of the HFS diet. Rats fed with either the HFS or a standard diet were tested after 10 weeks and again after 30 weeks. After 10 weeks of feeding, HFS-fed rats developed the metabolic syndrome, as manifested by an increase in fasting insulinemia, total cholesterol and triglyceride levels, as well as by impaired glucose tolerance. Furthermore, the plasma FA profile of the HFS group showed higher proportions of monounsaturated FAs like palmitoleic acid [16:1(n-7)] and oleic acid [18:1(n-9)], whereas the proportions of some polyunsaturated n-6 FAs, such as linoleic acid [18:2(n-6)] and arachidonic acid [20:4(n-6)], were lower than those in the control group. After 30 weeks of the HFS diet, we observed changes mainly in the levels of 16:1(n-7) (decreased) and 20:4(n-6) (increased). Together, our results suggest that an HFS diet could lead to an adaptive response of the plasma FA profile over time, in association with the development of the metabolic syndrome.  相似文献   

非酒精性脂肪性肝病和内脏脂肪厚度相关性研究     

夏涛  应利华  付美鸳  叶均 《金华职业技术学院学报》2012,12(3):76-79

目的：评价超声测量内脏脂肪厚度对非酒精性脂肪性肝病（NAFLD）的诊断和分级的价值。方法：收集2010年8月至2011年4月在某院体检中心进行健康体检资料共122例,NAFLD组74例,非NAFLD组48例,经超声测量内脏脂肪厚度。结果：超声测量内脏脂肪厚度在NAFLD组和非NAFLD组之间差异有显著性统计学意义（P=0．004）。轻度、中度、重度NAFLD组测量的内脏脂肪厚度经方差分析结果为差异有统计学意义（F=9．91,P〈0．001）,进一步用LSD法分析显示两两之间都有差异。经超声测量的VFT诊断NAFLD的ROC曲线下面积为0．794,p=0．011,诊断切点值为2．70cm。结论：经超声测量的内脏脂肪厚度可作为NAFLD诊断和分级的指标。  相似文献   

力竭性运动训练对大鼠血清甘胆酸含量的影响   总被引：5，自引：0，他引：5  

徐碧君 Bijun  X 《体育与科学》1999,20(6):57-59

为了研究运动训练对机体肝细胞功能的影响，通过对大鼠进行为期８周的不同 运动量的游泳训练，并测定血清乳酸脱氢梅酶、谷丙转氨酶、谷革转氨酶等酶的活性以 及甘胆酸（Ｃｈｏｌｙｌｇｌｙｃｉｎｅ，ＣＧ）含量。结果表明，血清酶活性在一定程度上可反映肝细胞 的损伤，但缺乏特异性，动态观察静息时血清甘胆酸含量可特异地反映肝细胞的功能状 态，对评定机体功能，预防运动性疲劳的产生具有十分重要的意义，  相似文献   

BRS Colleague MEDLINE End User Training Follow-up Survey     

《Medical reference services quarterly》2013,32(3):15-34

The amount of recent literature describing end user training programs is substantial, yet there are few reports evaluating the effectiveness of such training. This article reports on a follow-up survey of the first seventy-five trainees of a four-hour BRS Colleague MEDLINE training program at the Health Sciences Library of East Carolina University. The 90.7 percent response rate to the questionnaire provided information about both those who performed searches and those who had not. It indicated how trainees felt about their training, their ability to perform searches or reason for not performing searches, and types of additional training the trainees desired. Survey results are discussed in terms of effectiveness of the training for the end user with infrequent search needs, possible modifications to improve the effectiveness of the training, and possible alternatives to BRS Colleague MEDLINE.  相似文献