排序方式： 共有90条查询结果，搜索用时 15 毫秒
61.
目的 探讨耐力训练对非酒精性脂肪肝肝脏抗氧化系统及活性氧生成的影响.方法 雄性8周龄ApoE基因敲除小鼠24只,西方膳食14周后,随机分为2组,非酒精性脂肪肝模型组(H,n=12,14周),跑台运动组(E,n=12,14+12周).跑台运动12周,坡度为0°,跑速13m/min,60min/time,每周5次.在造模与训练结束后,测定顺乌头酸酶、总SOD、MnSOD、CuZnSOD和GPx酶的活性;MDA、谷光甘肽(GSH)和羟自由基(OH-的含量;Mn-SOD、谷光甘肽过氧化物酶(GPx)和NF-кBmRNA的表达,光镜观察脂肪肝病变程度.结果 耐力训练显著提高总SOD、MnSOD、CuZnSOD、顺乌头酸酶和GPX酶的活性和肝脏GSH含量;显著降低CAT的活性及肝脏OH-和MDA的含量:显著上调MnSOD和NF-кBmRNA表达,GPxmRNA未见显著性改变.结论 耐力训练可以有效提高非酒精性脂肪肝肝脏抗氧化系统的能力,减少活性氧生成,从而达到改善非酒精性脂肪肝的效果. 相似文献
62.
Ying ZHU Yi ZHENG Yuan-yuan SHEN Xin CHEN Xin-yu ZHANG Hao-ming LIN Yan-rong GUO Tian-fu WANG Si-ping CHEN 《Journal of Zhejiang University. Science. B》2014,15(4):375-381
研究目的：肝脏的纤维化进程改变肝脏组织的流变属性。创新要点：本文利用剪切黏弹性模量描绘并比较了大鼠肝脏F0期到F4期的纤维化过程。研究方法：两个黏弹性模型,即Zener模型和Voigt模型用于解释流变力学测试得到的实验数据,由此得到每个纤维化分期的肝脏弹性和黏性值。重要结论：肝脏中度纤维化（≤F2期）与黏弹性值密切相关。Zener模型的弹性均值E1从F0期的（0.452±0.094）kPa增加到F2期的（1.311±0.717）kPa,而Voigt模型的弹性均值E从F0期的（0.618±0.089）kPa增加到F2期的（1.701±0.844）kPa。Zener模型的黏性均值从F0期的（3.499±0.186）Pa·s增加到F2期的（4.947±1.811）Pa·s,而Voigt模型的黏性均值从F0期的（3.379±0.316）Pa·s增加到F2期的（4.625±1.296）Pa·s。无论选用哪个黏弹性模型,在F1期和F2期,肝脏弹性值的标准差比黏性值的标准差变化要小。因此,测得的弹性比黏性更有效地区分肝纤维化F0期到F2期。 相似文献
63.
Kaushik Kar Anindya Dasgupta M. Vijaya Bhaskar K. Sudhakar 《Indian journal of clinical biochemistry : IJCB》2014,29(2):232-237
Decompensation followed by death is the most serious outcome in patients suffering from cirrhosis of the liver. Alteration of trace elements may play a vital role in the process of decompensation. To examine the change in status of trace elements during the decompensation process, we analysed the zinc, copper, iron, magnesium, bilirubin and albumin levels in the serum of compensated (n = 34) and decompensated (n = 31) liver cirrhosis patients and compared them with healthy control group (n = 36) by post hoc ANOVA. We observed significant alteration in the selected micronutrients in the diseased group relative to healthy controls (P < 0.05). Moreover, mean serum zinc and iron levels were significantly lower with a higher level of serum copper in decompensated cirrhosis group than in compensated group (P < 0.05). However, no significant decrease of serum magnesium was found between the two diseased groups. Our findings imply that the trace elements like zinc, copper and iron might exert important contributory roles in decompensation process in liver cirrhosis and hence, may be utilized as important biomarkers for these patients. Furthermore, we propose that replacements of those micronutrients at an early stage can delay or prevent the severe outcomes like hepatic encephalopathy, gastrointestinal bleeding, severe jaundice or ascites in these patients. 相似文献
64.
目的：观察硫普罗宁治疗急性戊型肝炎的临床疗效和安全性.方法：急性戊型肝炎患者65例,随机分为治疗组33例,应用硫普罗宁0.2g加入5%葡萄糖注射液200ml中静脉滴注,每日1次;对照组32例,常规应用护肝药物如肌苷注射液等静脉滴注,疗程均为2周.观察治疗前后两组的症状、体征及肝功能情况.结果：硫普罗宁治疗后患者临床症状和肝功能均有显著改善.两组比较发现,ALT 好转情况、显效率和总有效率差异均有显著性（P＜0.05）.结论：硫普罗宁治疗急性戊型肝炎有较好疗效,且未见不良反应,用药安全. 相似文献
65.
Pradeep Naik B. Premsagar M. Mallikarjuna 《Indian journal of clinical biochemistry : IJCB》2015,30(1):94-98
The acute renal failure is the frequent medical complication observed in liver transplant patients. The objective of this study was to determine the cause of acute renal failure in post liver transplant patients. A total of 70 patients who underwent (cadaveric 52, live 18) liver transplantation were categorized based on clinical presentation into two groups, namely hepatorenal failure (HRF, n = 29), and Hepatic failure (HF, n = 41). All the patients after the liver transplant had received tacrolimus, mycophenolate and steroids. We analyzed the modification of diet in renal disease, (MDRD) serum urea, creatinine and albumin before and after 5th and 30th day of liver transplant and data was categorized into survivors and non-survivors group. In HRF survivor group, serum creatinine, and urea levels were high and, albumin, MDRD were low in pre- transplant and reached to normal levels on 30th day of post transplant, and 79.3 % of patients in this group showed resumption of normal kidney function. On the contrary in HRF nonsurvivor group, we did not observed any significant difference and 20.7 % of patients showed irreversible changes after the liver transplant. In HF survivor group, 82.9 % of liver failure patients did not show any deviation in serum creatinine, urea, albumin and MDRD, whereas in HF non survivor group, 17.1 % of liver failure patients who had HCV positive before the transplant developed acute renal failure. The levels of creatinine, urea, albumin and MDRD were normal before the transplant and on day 30th, the levels of albumin and MDRD were significantly low whereas serum urea, creatinine levels were high. In conclusion, based on these observations, an diagnosis and treatment of Acute renal failure is important among the liver transplantation cases in the early postoperative period. 相似文献
66.
Mohamed Hessien Mohamed Ayad Wafaa M. Ibrahim Batoul Izz ulArab 《Indian journal of clinical biochemistry : IJCB》2015,30(2):210-216
This work was designated to monitor the coagulation abnormalities associated with the gradual progression of liver diseases. The study included fifty patients; forty were diagnosed with liver cirrhosis with different stages categorized according to the Childs-Pugh classification and another ten patients were diagnosed with hepatocellular carcinoma (HCC). Haemostatic variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet count were estimated in patients and compared with the baseline levels of healthy subjects (n = 10). The results demonstrated that the fibrinogen level was progressively decreased, whereas PT was progressively prolonged in Child A, Child B and Child C groups. The maximum deterioration was observed in HCC patients. Calcium significantly increased in mild (Child A) and moderate (Child B) but not in Child C cirrhosis and HCC patients. FXIII level did not show any significant changes in cirrhotic patients compared to healthy group. Some of the haemostatic variables we investigated were correlated with serum albumin and bilirubin but not with aminotransferases (ALT and AST). The results indicated that the haemostatic abnormalities in fibrinogen, calcium and PT (but not FXIII) were deteriorated in parallel with the gradual regression of the constitutional function of liver. 相似文献
67.
Xia-ping Zhang Yuan-qiang Lu Wei-dong Huang 《Journal of Zhejiang University. Science. B》2010,11(6):433-436
Objective
To report a case of Wernicke encephalopathy in the early stage after surgery. 相似文献68.
梗阻性黄疸大鼠肝脏损害及血清毒性物质变化 总被引：1，自引：0，他引：1
目的：探讨梗阻性黄疸（梗黄）大鼠肝脏损害及其血清毒性物质的变化。方法：采用胆总管结扎方法建立梗阻性黄疸大鼠模型,将36只大鼠随机分为假手术（sham）组6只、梗阻性黄疸（CBDL）组30只（CBDL组又分为1周、2周、3周、4周、5周亚组,每组6只）。监测各组血液TNF-α、内毒素、肝功能变化。结果：CB—DL组均可见肝细胞坏死及增生,汇管区可见胆管扩张、胆汁淤积,肝组织改变随梗阻时间的延长而逐渐加重,血清内毒素及TNF-α含量与梗阻时间明显相关。结论：CBDL大鼠肝脏形态改变明显,血ALT、TBIL、内毒素、TNF-α含量明显升高,并与梗黄时间有关。 相似文献
69.
目的探讨银杏叶总黄酮对体外培养的人肝癌细胞HepG2增殖与凋亡的影响。方法将银杏叶总黄酮作用于体外培养的人肝癌细胞HepG2,MTT法检测其对HepG2细胞增殖的影响,缺口末端核苷标记（TUNNEL）法检测其对HepG2细胞凋亡的影响。结果银杏叶总黄酮对体外培养的人肝癌细胞HepG2的增殖效率下降,使凋亡细胞数增加（P〈0．01）,且呈剂量依赖效应。结论银杏叶总黄酮对体外培养的人HepG2细胞增殖有抑制作用,并能诱导细胞凋亡。 相似文献
70.
目的探讨丹参注射液抗肝纤维化作用机理.方法取40只成年wistar大鼠,利用猪血清腹腔注射法,连续6周,复制免疫性肝纤维化模型.治疗组采用大、小剂量丹参液肌肉注射,其剂量分别为0.3ml/kg和0.15ml/kg,每日一次,连续4周.取肝脏切片,HE和Mollory染色,光镜下观察.检测血清SOD活性、MDA含量和肝功能.结果大剂量治疗组肝细胞空泡减少,胶原纤维大部分消失,SOD活性增高,MDA含量降低,与模型组比较有显著性差异(P＜0.05).结论大剂量肌注丹参液,具有治疗肝纤维化的功能. 相似文献