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Harleen Mangat Tajamul Hussain C Sundaram MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(2):74-79
Poly A RNA status and itsin vitro translation in a rabbit reticulolysate cell free system, were assessed in the skeletal muscle of young boys with Duchenne
muscular dystrophy. Compared to normals there is a significant 48% increase in poly A RNA content of dystrophic muscle and
its translatability was increased by 56% based on35S methionine incorporation into total protein systhesised. Immunoprecipitation of the translated products with monospecific
antibodies showed that there is a 2.6 fold and a 2 fold increase in m and μ calpains respectively. This underlines the importance
of both synthetic and degenerative activities in the early pathology in DMD muscle. 相似文献
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Evan Harris MP 《Learned Publishing》2005,18(2):85-89
The response of the UK Government to the Report on science publishing by the Science and Technology Select Committee of the House of Commons is criticized for failing to take the necessary action to research or help catalyse a change in the publishing model. The initiatives of the National Institutes of Health and the Wellcome Foundation in setting up central archives are examined and their utility questioned. The evidence base for a change to open access is explored. 相似文献
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P. Aruna Prabhavathi Tajamul Hussain G. N. Mallikarjuna Rao MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(1):94-98
The efficacy of two intragenic polymorphic markers of factor VIII gene has been examined in Andhra Pradesh population with
a view to confirm/revise the strategy for carrier detection that would be precise and economical. The haemophilia A carrier
was detected using Bcl I and Xba I polymorphic sites in intron 18 and 22 respectively. The cumulative efficiency of these
two sites for detection of carriers is 100% since all 15 families tested were informative for one of these polymorphisms,
thus confirming their usefulness for factor VIII gene mutations found in Andhra Pradesh. 相似文献
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