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Harleen Mangat Tajamul Hussain C Sundaram MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(2):74-79
Poly A RNA status and itsin vitro translation in a rabbit reticulolysate cell free system, were assessed in the skeletal muscle of young boys with Duchenne
muscular dystrophy. Compared to normals there is a significant 48% increase in poly A RNA content of dystrophic muscle and
its translatability was increased by 56% based on35S methionine incorporation into total protein systhesised. Immunoprecipitation of the translated products with monospecific
antibodies showed that there is a 2.6 fold and a 2 fold increase in m and μ calpains respectively. This underlines the importance
of both synthetic and degenerative activities in the early pathology in DMD muscle. 相似文献
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Cannon JE Easterbrooks SR Gagné P Beal-Alvarez J 《Journal of deaf studies and deaf education》2011,16(4):437-457
The purpose of this study was to determine if the frequent use of a targeted, computer software grammar instruction program, used as an individualized classroom activity, would influence the comprehension of morphosyntax structures (determiners, tense, and complementizers) in deaf/hard-of-hearing (DHH) participants who use American Sign Language (ASL). Twenty-six students from an urban day school for the deaf participated in this study. Two hierarchical linear modeling growth curve analyses showed that the influence of LanguageLinks: Syntax Assessment and Intervention (LL) resulted in statistically significant gains in participants' comprehension of morphosyntax structures. Two dependent t tests revealed statistically significant results between the pre- and postintervention assessments on the Diagnostic Evaluation of Language Variation-Norm Referenced. The daily use of LL increased the morphosyntax comprehension of the participants in this study and may be a promising practice for DHH students who use ASL. 相似文献
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P. Aruna Prabhavathi Tajamul Hussain G. N. Mallikarjuna Rao MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(1):94-98
The efficacy of two intragenic polymorphic markers of factor VIII gene has been examined in Andhra Pradesh population with
a view to confirm/revise the strategy for carrier detection that would be precise and economical. The haemophilia A carrier
was detected using Bcl I and Xba I polymorphic sites in intron 18 and 22 respectively. The cumulative efficiency of these
two sites for detection of carriers is 100% since all 15 families tested were informative for one of these polymorphisms,
thus confirming their usefulness for factor VIII gene mutations found in Andhra Pradesh. 相似文献
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