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1.
The brachistochrone problem posed by Bernoulli and its solution highlights one of the most famous experiments in physics which illustrates the variational principle. This pedagogical study is designed to ignite a classroom discussion on the variational problem. We overview the Euler–Lagrange formalism of the variational principle and obtain the solution to the brachistochrone problem. We demonstrate the success of the variational method using brachistochrone models which were fabricated specially for this purpose.  相似文献   
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Urinary abnormalities were evaluated in 100 renal stone patients with first episode of renal stone having age 22 to 45 years from both sex and compared to 100 normal healthy control group having same age group from both sex. Twenty-four hours urinary oxalate, calcium, uric acid, sodium, magnesium, phosphorus and citrate were estimated. The urinary pH was also determined. In stone formers urinary oxalate, calcium, sodium and uric acid excretions were significantly higher when compared with control group. Whereas citrate, phosphate and magnesium excretion were significantly lower in stone formers when compared with control. The pH of urine in stone formers was lower than the controls. High dietary intake of purine rich diet causes elevated excretion of uric acid, which leads to calcium oxalate crystal formation and precipitation. Other risk factors such as urinary oxalate, calcium also related to formation of renal calculi. Hypocitraturia is the main cause of renal calculi along with hypomagnesiuria and hypophosphaturia in the patient of Marathwada region. On the basis of urinary abnormalities further stone formation in the patient can be prevented by dietary modifications.  相似文献   
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Educational technology research and development - This paper explores technology integration and the role of teacher beliefs in this integration to assess a ‘smart-class’ initiative...  相似文献   
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Output reversibility involves dynamical systems where for every initial condition and the corresponding output there exists another initial condition such that the output generated by this initial condition is a time-reversed image of the original output with the time running forward. Through a series of necessary and sufficient conditions, we characterize output reversibility in linear discrete-time dynamical systems in terms of the geometric symmetry of its eigenvalue set with respect to the unit circle in the complex plane. Furthermore, we establish that output reversibility of a linear continuous-time system implies output reversibility of its discretization. In addition, we present a control framework that allows to alter the system dynamics in such a way that a discrete-time system, otherwise not output reversible, can be made output reversible. Finally, we present numerical examples involving a discretization of a Hamiltonian system that exhibits output reversibility and an example of a controlled system that is rendered output reversible.  相似文献   
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Cytokines, viral load and opportunistic infections play an important role in HIV-disease progression. Hundred children vertically infected with HIV were enrolled to determine mRNA levels of TNF-α, IL-10, IL-4 and IFN-γ. These levels were estimated by amplifying cytokine mRNA from peripheral blood mononuclear cells. Severity of HIV was staged by the reduction in CD4 + T cells and the onset of opportunistic infections. IL-10 mRNA levels were observed to increase with the severity. Despite the rising IL-10 mRNA levels, TNF-α mRNA levels increased with severity of HIV and decrease in CD4 + T cell counts. IL-4 mRNA levels increased with the reduction in CD4 + T cell numbers. Depleting mRNA levels of IFN-γ contributed to the worsening of HIV disease. Increase in TNF-α and IL-4 levels appended to the disease severity by upregulation of the viral replication. Increased IL-10 levels and decreased IFN-γ levels predisposed the children to HIV associated opportunistic infections, which in return contributed to cytokine disarray.  相似文献   
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P. C. Deshmukh  J. Libby 《Resonance》2010,15(10):926-940
This article is the second part of our review of the important role that symmetry plays in atomic and subatomic physics. We will concentrate on the discrete symmetries — parity, charge conjugation, and time reversal — that have played a significant part in the development of the ‘standard model’ of particle physics during the latter part of the 20th century. The importance of experimental tests of these symmetries, in both atomic and particle physics, and their sensitivity to new phenomena is also discussed. To conclude, we describe how ‘symmetry breaking’ in the standard model leads to the generation of mass via the Higgs mechanism and how the search for evidence of this symmetry violation is one of the principal goals of the Large Hadron Collider, which began operating at CERN, Switzerland in 2009.  相似文献   
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This feature presents research undertaken by Archana Deshmukh for her MA dissertation at the University of Brighton. She worked closely with Tom Roper, the Clinical Librarian at Brighton and Sussex University Hospitals NHS Trust, in a project to explore the feasibility of applying quantitative measures to evaluate the Clinical Librarian service. The investigation used an innovative participatory approach and the findings showed that although an exclusively quantitative approach to evaluation is not feasible, using a mixed methods approach is a way forward. Agreed outputs and outcomes could be embedded in a marketing plan, and the resulting framework could provide evidence to demonstrate overall impact. Archana graduated in July 2014, gaining a Distinction in the MA in Information Studies, and she is currently looking for work in the health information sector.  相似文献   
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One atom thick graphene is derived from graphite and is a new material; however, graphite has been a part of human history for centuries. In this article we discuss why it generates so much excitement in a wide variety of scientific disciplines. We emphasize its electronic and mechanical properties with an eye towards applications that may impact our lives sooner, rather than later. We also review methods to make this wonder material, including the famous ‘scotch-tape’ technique that led to the Nobel-Prize winning research.  相似文献   
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