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Although angiogenetic therapy using recombinant growth factors holds much hope for the treatment of ischaemic diseases, there are still many unanswered questions, including the method of administration, the correct dose of these factors, and the duration of the therapeutic approach. Exercise has also been suggested to induce neovascularizaiton in muscles. We evaluated the angiogenetic effects of the intramuscular administration of basic-fibroblast growth factor (b-FGF) and acidic-fibroblast growth factor (a-FGF) in rat heart, compared with rats who exercised daily. In conclusion, both the intramuscular administration of b-FGF and exercise increased significantly angiogenesis in the heart in contrast to the intramuscular administration of a-FGF, which was ineffective.  相似文献   
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The authors assessed the influences of several risk factors—self‐esteem, history of unwanted sexual contact (USC), depression, and sorority membership—on eating‐related and weight‐related attitudes and behaviors. Findings provide support for the roles of self‐esteem, depression, and USC on restricting attitudes. According to the authors' model, these independent variables predicted restricting attitudes that then predicted restricting behaviors. Implications for preventive interventions and the study's limitations are discussed.  相似文献   
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DATA FROM the Mother‐Child Project, a longitudinal study of high‐risk children, indicated that the percentage of children referred for school‐based problems was approximately 40% in grades one, two and three. Basically all of the children who were referred were receiving some form of educational services. Similarly, the majority of children achieving below the 25th percentile on a standardized achievement test were receiving special educational services. The reasons some of the low‐achieving students were not receiving services were higher social adjustment, better work habits and a past educational history of success as compared to those low‐achieving students who were receiving services. Greater differences between served and unserved groups were found on historical rather than current measures, which suggests that the chronicity of educational problems had a major impact in determining which students received services. The results suggest that across the large number of schools serving high‐risk children in our sample, excellent decisions were made in terms of who received special educational assistance. There did not appear to be any bias in the referral process or in making the decision of whom to serve. This finding contradicts the results of other investigators in this area. The results from the current investigation indicate that a high proportion of high‐risk children were having difficulty in school. We were encouraged to find, however, that the high‐risk students in need of special assistance were being served.  相似文献   
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This study chronicled the professional journeys of two beginning science teachers. The focus of the research effort documents what brought them to science teaching and investigated their resulting career paths. Data artifacts for this instrumental case study approach included: interviews, written survey responses, personal communications and member checks. All data was transcribed and coded into emergent categories using a constant comparative analysis approach. The findings indicated that their decisions to enter and leave teaching were a complex mélange of issues that included career disposition, notions of isolation, overarching culture of the school, and future possibilities. However, most striking was their re-entry into teaching on a temporary basis after considerable time away from the classroom, which suggests that teachers develop a sense of agency regarding their career decisions. This may require researchers to reconsider how we view teacher decision-making within the context of teacher attrition and mobility. Implications for science teacher education indicate that some teachers may enter the profession considering teaching to be a transition into a different career path. Secondary science teachers may perceive multiple career options (beyond the classroom) based on their preparation and teaching experience. Further implications and possibilities for science teacher education are discussed.  相似文献   
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We examine classroom situations which allow the learning of rules of mathematical reasoning. Drawing on an epistemological analysis and G. Brousseau's theory of situations, we define a priori theoretical characteristics which such situations must possess. We then use this analysis, and hypotheses about the cognitive functioning of pupils of this age, to establish learning situations for the rule of the excluded middle, and for the use of the figure in geometry. We report the results of experimentation with two of thses situations and show that, through the study of a mathematical problem, debate about these rules can be generated amongst students aged twelve to thirteen. We explain why, in our opinion, for epistemological reasons linked to the two particular rules concerned, it is necessary for the teacher to conclude the debate, and we examine our cognitive hypotheses against the actual results of experimentation.  相似文献   
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