Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels     

Michael Sponder  Ioana-Alexandra Campean  Michael Emich  Monika Fritzer-Szekeres  Brigitte Litschauer  Jutta Bergler-Klein 《Journal of sports sciences》2017,35(21):2129-2134

Cathepsin S (CS) was shown to play a key role in cancer progression, atherosclerosis, heart valve disease, insulin resistance and diabetes mellitus. The present prospective study aimed to investigate the influence of sports on CS, interleukin-6 (Il-6) and high-sensitivity C-reactive protein (hsCRP) levels.

Ninety-eight of 109 participants completed the study. Ergometries were performed at baseline and after 8 months to evaluate/quantify the performance gain. Blood samples were taken at baseline and every 2 months. CS was measured by ELISA (enzyme-linked immunosorbent assay). Compared to the control group (mean performance gain ?3.41 ± 4.62%) we observed a significant physical-activity-induced increase of CS levels (3.45–3.73 ng · ml^?1; P = 0.027) and a significant decrease of Il-6 (2.43–1.91 pg · ml^?1; P = 0.031) and hsCRP-levels (0.11–0.09 mg · dl^?1; P = 0.001) in the intervention group (mean performance gain: 12.13 ± 6.32%). Furthermore, the tendency of the progression was significant for CS and Il-6 (P = 0.002/0.033).

We could show a significant sports-induced decrease of the classic inflammation parameters hsCRP/Il-6, probably expressing a downregulation of permanently prevalent inflammation processes. Simultaneously CS levels increased significantly. Our results show that increasing CS amounts are not simply to equal with an enhanced inflammation status and might even have beneficial effects on inflammation and angiogenesis.  相似文献   

Teacher Empathy and Attitudes Towards Individuals with Disabilities     

Monika Parchomiuk 《International Journal of Disability, Development & Education》2019,66(1):56-69

The article presents research results of a study aimed at determining the correlation between empathy understood as a personality disposition and general attitudes towards individuals with disability. The sample consisted of 300 special education teachers working with persons with intellectual disabilities in primary and secondary schools and institutions of rehabilitation, and 280 general education teachers working with able-bodied students in primary and secondary schools. Two instruments were used: Empathic Understanding of Other People Questionnaire, and the Scale of Attitudes towards Individuals with Disability. In the group of special education teachers, only Syndrome 2 of empathy was statistically significant for shaping the attitudes, whereas among teachers, Syndromes 1, 3 and 4 were significant. In Syndromes 1, 2 and 4, including the highest level of emotional, cognitive, motivational and communication aspects of empathy, the correlations were positive as expected. In the case of Syndrome 3, including the considerable level of cognitive empathy, the correlation was negative.  相似文献   

WOMEN IN DISTANCE STUDY ‐ WOMEN STUDENTS AT THE FERNUNIVERSITAT IN HAGEN (FEDERAL REPUBLIC OF GERMANY)     

Michaele Hetzel  Monika Schneidereit  Angela Schuch 《Higher Education in Europe》1981,6(3):18-22

The authors take up the hypothesis that distance education was also meant to facilitate the access of women to higher education. Recent studies carried out at the University for Distance Education at Hagen show that results do not always match expectations. By analysing in detail the causes for this partial failure, the authors come forward with some remedial proposals.

The authors are all members of the staff of Hagen University.  相似文献   

Effect of Tara (Caesalpinia spinosa) Pod Powder on the Oxidation and Colour Stability of Pork Meat Batter During Chilled Storage     

Monika Skowyra  Urszula Janiewicz  Anna Marietta Salejda  Gra?yna Krasnowska  María Pilar Almajano 《Food Technology and Biotechnology》2015,53(4):419-427

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Neo-Aristotelian mereology     

Ralf M. Bader 《Metascience》2010,19(3):413-415

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Perspective Paper: Assessing Air Quality as Part of a Physical Therapy Plan of Care     

Dennis C. Sobush  Monika Burrescia 《Cardiopulmonary Physical Therapy Journal》2011,22(1):20-24

Purpose: The purposes of this clinical perspective paper are (1) to expand physical therapists’ awareness to the topic of air quality as a health priority when providing professional services; and (2) to provide templates for screening the indoor clinical environments and patient profiles to avert respiratory exacerbations, especially in persons with asthma. Summary of Key Points: The location where a physical therapist practices determines the air quality indices to which a person is exposed. Poor indoor air quality can expose a person to even greater compromise of respiration (ie, Sick Building Syndrome) than outdoor air quality secondary to an array of factors like building materials, the ventilation exchange rate of an enclosed space, chemicals used in cleaning, and humidity. Statement of Conclusions: Extrinsic (ie, environmental) and intrinsic (eg, pre-disposition to airway hypersensitivity) factors must be accounted for by physical therapists to safeguard their patients and themselves from experiencing respiratory compromise and/or distress as a result of a treatment session or their place of employment. Recommendations: Efforts to screen indoor environments for potential triggers and patient risk profiles for abnormal airway reactivity should routinely be undertaken. Individualized Action Plans should be prospectively prepared and readied for implementation when warranted.Key Words: asthma, Sick Building Syndrome, indoor air quality, respiratory impairment  相似文献   

The effect of patellar taping on EMG activity of vasti muscles during squatting in individuals with patellofemoral pain syndrome     

Mostamand J  Bader DL  Hudson Z 《Journal of sports sciences》2011,29(2):197-205

Although patellar taping has been shown to reduce pain in participants with patellofemoral pain syndrome, the mechanisms of pain reduction have not completely been established following its application. The purpose of this study was to evaluate EMG activity of vastus medialis and vastus lateralis following the application of patellar taping during a functional single leg squat. Both vastus medialis obliquus-vastus lateralis onset and vastus medialis obliquus/vastus lateralis amplitude of 18 participants with patellofemoral pain syndrome and 18 healthy participants as controls were measured using an EMG unit. This procedure was performed on the affected knee of participants with patellofemoral pain syndrome, before, during, and after patellar taping during unilateral squatting. The same procedure was also performed on the unaffected knees of both groups. The mean values of vastus medialis obliquus-vastus lateralis onset prior to taping (2.54 ms, s = 4.35) were decreased significantly following an immediate application of tape (-3.22 ms, s = 3.45) and after a prolonged period of taping (-6.00 ms, s = 3.40 s) (P < 0.05). There was also a significant difference between the mean values of vastus medialis obliquus-vastus lateralis onset among controls (-2.03 ms, s = 6.04) and participants with patellofemoral pain syndrome prior to taping (P < 0.05). However, there were no significant difference between the ranked values of vastus medialis obliquus/vastus lateralis amplitude of the affected and unaffected knees of participants with patellofemoral pain syndrome and controls during different conditions of taping (P > 0.05). Decreased values of vastus medialis obliquus-vastus lateralis onset may contribute to patellar realignment and explain the mechanism of pain reduction following patellar taping in participants with patellofemoral pain syndrome.  相似文献   

New methods of information management: new roles for the health sciences library.     

S A Bader  E R Martin 《Medical reference services quarterly》1987,6(3):63-68

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Questions and positions on education for sustainable development at university in France: example of short professional cycles     

Angela Barthes  Yves Alpe  Barbara Bader 《Environmental Education Research》2013,19(3):269-281

The questions focus on the emergence of education for sustainable development in the French university. The case study discusses the curricular examination of the Bachelor of Territory Professional Planning in 17 universities and the diachronic evolution, between 2001 and 2011, of their educational content around sustainable development. The analysis leads to a reflection on the specificity of French contexts, compared to international positions. Indeed, the legitimacy of the education provided is queried against the economization of the educational sphere. Didactic problems are posed by the reduction of distances between social practices and knowledge mobilized for the teachings. The evolution of the ‘school form’ and the specific place of ‘educations for’ in the framework of the institution are questioned.  相似文献   

A nano to macroscale study on structure-mechanics relationships of archaeological oak     

Thomas K. Bader  Karin de Borst  Karin Fackler  Thomas Ters  Susan Braovac 《Journal of Cultural Heritage》2013,14(5):377-388

Mechanical properties of wood at different length scales of its hierarchical structure are governed by structural and compositional properties on smaller length scales. This opens up the possibility to use microstructural data for estimating mechanical properties, which are difficult to assess by conventional, destructive testing but are nevertheless of high relevance for conservation practice. Herein, we investigate such microstructure-mechanics relationships for a particular example, namely the load bearing archaeological oak of the Oseberg Viking ship, displayed at the Viking Ship Museum in Oslo, Norway. In order to identify the effects of degradation on the mechanical behavior and their relations to the microstructure, recent oak specimens of different geographical origin (Norway and Austria) are investigated as well. Wood exhibits a cellular structure. Its cell walls are composed of an amorphous polymer matrix consisting of lignin and hemicelluloses and embedded, stiff cellulose fibers. At the cell level, experimental studies comprised microscopic investigations of the cellular structure, chemical analyses of the composition of the cell walls, as well as nanoindentation tests on single cell walls. The same samples were also analyzed on the macroscopic level, where additionally mass density and annual ring data were measured together with ultrasonic stiffnesses. The chemical data clearly indicate deterioration in the archaeological oak, affecting mainly hemicelluloses and amorphous cellulose. At the cell wall scale, however, this does not necessarily lead to a weaker material behavior. The nanoindentation modulus, as a measure of the cell wall stiffness, was found to even increase. This is counterintuitive to our understanding of the effects of chemical degradation. It might be due to possible modification of lignin in the Oseberg oak, and thus have a stronger effect on the indentation modulus than the concurrent weakening of the interfaces between the load-carrying cellulose fibers and the connecting cell wall matrix when analyzing wood at the microscopic level. A similar effect is also observed for the transversal stiffness of macroscopic samples, which increases. In tension-dominated loading modes, however, the degradation of the interfaces is the dominant effect, resulting for example in a considerable reduction of the macroscopic stiffness in longitudinal direction. This underlines the utmost relevance of the loading condition on the remaining load-carrying capacity of degraded wood. On the macroscale, effects of the geographical origin (i.e. growth conditions) on ring characteristics of the oak tissues override the effects of degradation on the mechanical behavior. They have to be carefully extracted in order to come up with conclusions on the effect of degradation from macroscopic test results. The identified microstructure-mechanics relationships provide the basis for–in further research steps–building mathematical models describing the relations between microstructural characteristics and macroscopic mechanical properties and, thereon, for structural analyses of historical wooden objects.  相似文献