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1.
Neelima Verma Jyoti chakraverty Pankaj Baweja Alka Girotra Leena Chatterjee Manish Chugh 《Indian journal of clinical biochemistry : IJCB》2017,32(1):117-120
Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc. A case study in our hospital showed extremely high ferritin values along with low hemoglobin, elevated LDH and triglycerides with positive MRSA in sputum culture and macrophage proliferation and hemophagocytosis in the bone marrow examination. Patient showed definite inverse relation with steroid therapy and serum ferritin levels. 相似文献
2.
Anissa Kaleemullah Shariff Sangita R. Patil Pramod S. Shukla Ajit V. Sontakke Anup S. Hendre Anand K. Gudur 《Indian journal of clinical biochemistry : IJCB》2009,24(3):307-311
The objectives of the present study were to ascertain the variations in the serum levels of malondialdehyde and total antioxidant
status, in head and neck malignancies with different stages, with and without oral antioxidant supplementation, before and
after radiotherapy, and to validate the protective effects of an antioxidant supplementation during radiotherapy. The pretreatment
values of serum malondialdehyde were significantly raised, while that of serum total antioxidant status were significantly
declined in all the stages of head and neck malignancies, when compared with the healthy controls values (P<0.001). A significant
correlation was observed related to the studied parameters and different stages of the disease. The study suggests that an
oral antioxidant supplementation during radiotherapy is an effective mode in reducing oxidative stress. Antioxidant supplementation
during radiotherapy may serve as an adjuvant therapy in malignancies offering a protection to normal cells that may further
reduce the risk of developing secondary cancers. 相似文献
3.
Alka Singh Sheila Uthappa V. Govindaraju T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):25-28
The present study conducted on twenty-five uncomplicated cases of acute myocardial infarction diagnosed by clinical and electrocardiographic
findings indicated significantly increased level of cardiac Troponin-T and increased activities of the enzymes total creatine
kinase, creatine kinase-MB, aspartate transaminase and lactate dehydrogenase as compared to the twenty-five healthy control
subjects. The level of cardiac Troponin-T and the activities of the enzymes total creatine kinase, creatine kinase-MB, aspartate
transaminase and lactate dehydrogenase was found to be higher in “Q” wave myocardial infarction patients as compared to the
non-“Q” wave and the controls. Since cardiac Troponin-T has been shown to increase in unstable angina and renal failure without
cardiac disease and creatine kinase-MB activity has been found to be normal in patients with unstable angina and increase
very slightly in patients with renal failure, it was concluded that a combination of cardiac Troponin-T and creatine kinase-MB
activity was sufficient for the early diagnosis of acute myocardial infarction. 相似文献
4.
5.
Chavan VU Durgawale PP Sayyed AK Sontakke AV Attar NR Patel SB Patil SR Nilakhe SD 《Indian journal of clinical biochemistry : IJCB》2011,26(3):283-289
Twenty-four hour urinary albumin excretion (UAE) is considered as gold standard method for albuminuria measurement, but collection
of 24-h urine is inconvenient. The aim of present study was to evaluate whether albumin: creatinine ratio (ACR) and urinary
albumin concentration (UAC) in different spot urine samples correlate or not with 24-h UAE for screening of microalbuminuria
in type 2 diabetic patients. We collected first morning void (FMV), random urine sample (RUS) and 24-h urine, separately on
consecutive days from 104 type 2 diabetic patients. ACR and UAC in each spot urine sample compared with 24-h UAE with regard
to Pearson correlation coefficient. Pearson’s correlation of albumin: creatinine ratio (ACR) with 24-h UAE was (r = 0.802 and 0.623) in first morning void (FMV) and random urine sample (RUS), respectively. Pearson’s correlation coefficient
of urinary albumin concentration (UAC) compared with 24-h UAE was (r = 0.943 and 0.920), in FMV and RUS, respectively, P < 0.01. Results revealed that values in first morning void (FMV) were better correlated with 24-h urinary albumin excretion
(UAE), than the values in random urine sample (RUS). We conclude that the first morning void (FMV) may be able to replace
24-h urine collection, preferably urinary albumin concentration (UAC) in the initial screening of microalbuminuria in diabetic
patients. 相似文献
6.
It is a well established fact that long term use of oral contraceptives is hazardous to health. The most common methods of contraception used by women in reproductive age group include use of oral contraceptives and copper «T». One of the causative factors for the side effects of the «pill» is presumed to be increase in serum cereloplasmin levels which has pro-oxidant activity. The present study involves the study of serum ceruloplasmin levels in two groups of subjects i.e. 30 women using oral contraceptive and 30 women using copper «T». 30 healthy females in reproductive age group were chosen as controls. It was observed that oral contraceptives increase the serum ceruloplasmin levels (p < 0.001) and the difference is highly significant as compared to no change (p < 0.1) in the groups using copper «T» as contraceptives. 相似文献
7.
Pushpa P. Durgawale P. S. Shukla Shubhangi D. Sontakke P. G. Chougule 《Indian journal of clinical biochemistry : IJCB》2001,16(1):110-112
In the present study the property of lectin agglutination in blood on normal and different cancer patients has been observed.
The purifiedSynadenium grantii root lectin was non blood group specific and its utility as a diagnostic tool in malignancy was studied. Hemagglutination
(units/ml) of red blood cells of different types of cancer was compared with the normal control's red blood cells. Out of
113 total cancer patients, only a group of 29 breast cancer patients showed significant increase in titre value (P<0.05) compared
to normal control. 相似文献
8.
Venkatraman Chandra-Mouli Marina Plesons Alka Barua Aparajita Gogoi Manju Katoch Mohammed Ziauddin 《American journal of sexuality education》2018,13(2):147-169
Since 2006, Udaan—a school-based adolescent education program in Jharkhand, India—was the only at-scale state-run program in the country. To determine factors that contributed to Udaan's scale-up and longevity, this study drew information from programmatic reports and interviews with the Centre for Catalyzing Change staff. Key factors for Udaan's success included an enabling policy environment, a willing government that supported and operationalized the program, a knowledgeable and committed NGO partner, sustained funding, and a commitment to constant improvement through evaluation. Udaan provides an example of a well-designed, implemented, and evaluated school-based adolescent health program that has been operating at scale over a sustained period. Other programs in India and elsewhere can benefit from learning from Udaan's experience. 相似文献
9.
Devika Tayal Binita Goswami S. K. Patra Reva Tripathi Alka Khaneja 《Indian journal of clinical biochemistry : IJCB》2014,29(2):139-144
Preeclampsia is a multisystem disorder associated with maternal hypertension, placental abnormalities and adverse fetal outcomes. The various pathways involved in its etiology include endothelial dysfunction, inflammatory milieu, lipid peroxidation and immunological imbalance. The present study was conducted to evaluate the causative and predictive role of nitric oxide, lipid peroxidation end products (MDA) and inflammatory cytokines (IL-6, TNF-α) in clinical presentation, severity and fetal outcome in preeclampsia. The study population was divided into 3 groups- Non- pregnant females comprising the control population; G1 and G2 groups included normal pregnant and pregnant females with preeclampsia with 50 patients in each group. Nitric Oxide and MDA levels were found to be highest in the preeclamptic patients as compared to other two groups. ROC curve analysis shows the superiority of the inflammatory markers as determinants of severity of preeclampsia which suggests the emerging role of pro inflammatory markers in the various pathological changes in preeclampsia. TNF-α emerged as the best marker in multivariate analysis and thus, has the potential for being used as a marker for PIH. Our study illustrates the multifactorial etiology of preeclampsia involving oxidative stress, proinflammatory milieu and endothelial dysfunction. 相似文献
10.
Sarita N. Chavan Umesh More Shruti Mulgund Vishal Saxena Alka N. Sontakke 《Indian journal of clinical biochemistry : IJCB》2007,22(2):101-105
Osteoporosis encompasses a wide spectrum of conditions associated with imbalance of osteoclastic and osteoblastic activities.
The increased activity of osteoclasts leads to increased free radical formation and hence lipid peroxidation. Present study
probes into the role of antioxidants as a palliative treatment for osteoporosis. It involved 50 healthy controls and 75 clinically
diagnosed osteoporosis patients. Both the groups underwent baseline assessment of biochemical markers viz. osteoblastic markers:
serum Alkaline phosphatase. Free or ionic calcium and Inorganic phosphorus, osteoclastic markers: serum Tartarate resistant
acid phosphatase and Malondialdehyde and the antioxidant status: serum Superoxide dismutase and Erythrocyte reduced glutathione.
The osteoporotic group was then divided into groups A (Vitamin E-Evinal 400 mg), B (Vitamin C-Celin 500 mg), C (Vitamin E+C-Evinal+Celin)
for antioxidant supplementation for a period of 90 days. The results reveal that there is significant fall in concentration
of serum MDA (p<0.001), TrACP (p<0.01). Improvement in antioxidant status is reflected by significant rise in concentration
of serum SOD (p<0.001) and erythrocyte GSH (p<0.001) after 90 days of antioxidant supplementation in osteoporosis. The findings
indicate that on the whole bone status improved with prolonged antioxidant vitamin supplementation, which can be used as a
palliative treatment for osteoporosis. The efficacy is not affected whether the vitamins are administered singly or conjointly. 相似文献