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1.
Making literature and learning relevant to students is inextricably linked to giving them ownership in an English classroom. This essay looks at the Eurocentric nature of the study of literature and the problems that creates when trying to make canonical texts relevant through the paradigm of race. The ambiguous role of literature as an empowering and oppressive force is discussed from the perspective of the student and teacher alike. Race relations in the classroom are explored through the public and private dialogue initiated through the teaching of Othello in an East End comprehensive school. 相似文献
2.
Biswas D Vettriselvi V Choudhury J Jothimalar R 《Indian journal of clinical biochemistry : IJCB》2011,26(2):172-177
Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type
2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and
type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with
75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR
based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp)
and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and
type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312–10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for
type 2 diabetes. 相似文献
3.
Ipsita Choudhury R. Jothimalar Arun Kumar Patra 《Indian journal of clinical biochemistry : IJCB》2012,27(3):265-269
Hypertension, a well known risk factor for various cardiovascular, peripheral vascular and renal events is an important public health challenge. Renin angiotensin system (RAS) being the most vital pathogenic mechanism of hypertension is mediated by a key component; the angiotensin converting enzyme (ACE). The present study was aimed to know the relationship of ACE gene polymorphism and the possible risk of development of hypertension in south Indian population. The study included 101 clinically diagnosed hypertensive patients without any associated disease condition and 81 age and sex matched apparently healthy controls. Genotyping was performed using a polymerase chain reaction, (PCR) amplification of the intron 16 fragment harboring the 287 bp Alu repeat sequence. Three possible genotypes D/D, I/I homozygous and I/D heterozygous were analyzed where the D/D genotypes corresponds to higher ACE levels (D-Deletion, I-Insertion). The PCR products were separated on 2 % agarose gel. Statistical analysis was performed using SPSS.15 software program. We found a significance in frequency of D/D genotype in the hypertensive patients compared to the control group (p = 0.0005, odd’s ratio = 4.157). This suggested that ACE (D/D) genotypes are more prone for the development of hypertension. This is relatively a pilot study; but nevertheless may assist in identifying the pathophysiological cause of hypertension. 相似文献
4.
Y. Srinivasa Rao B.K. Choudhury 《Library Collections, Acquisitions, and Technical Services》2010,34(4):105-114
The main purpose of the paper is to find out the provision of providing Networked Services (NSs) among National Institute of Technology (NIT) libraries in India. Methodology used for collecting data was questionnaire. The survey findings indicate that the majority of libraries prefer to provide communication network services (telephone, Internet, e-mail, facsimile etc), online journals (90%), automated catalog system (85%), multimedia databases (85%) and support (70%) services rather than the other services. Concerning the zone wise performance, south zone (80%) libraries are more potential than the other zone libraries in providing NSs. 相似文献
5.
Seema Bhargava Annsh Bhandari Sangeeta Choudhury 《Indian journal of clinical biochemistry : IJCB》2018,33(1):16-20
A high circulating concentration of the non proteinogenic amino acid homocysteine has been implicated as a risk factor for Alzheimer’s Disease and its prodromal stage, mild cognitive impairement. Furthermore, hyperhomocysteinaemia has been directly attributed to a deficiency in vitamins B12, folate, and B6. Several studies have demonstrated decrease in progression of mild cognitive impairement to Alzheimer’s Disease, and some have even shown an improvement in cognition after vitamin supplements with B12 and folate. Plausible mechanisms linking hyperhomocysteinaemia to Alzheimer’s and cognitive impairement have been hypothesized and demonstrated in hyperhomocysteinemic mice models. However, some studies have not elucidated any benefit of vitamin supplements in subjects with cognitive impairment. Hence, multicentric clinical studies need to be conducted to substantiate the mechanisms of neuronal degeneration due to hyperhomocysteinaemia and to demonstrate the beneficial effect of folate, B6 and B12 supplements on cognition. 相似文献
6.
Angom Ranjana Devi Mahuya Sengupta Dipu Mani Barman Yashmin Choudhury 《Indian journal of clinical biochemistry : IJCB》2021,36(3):296
Nicotine, responsible for the addictive properties of tobacco, is widely used in nicotine replacement therapy for tobacco use cessation. We investigated the time-dependent effect of treatment with nicotine on the tumor suppressor, DNA repair and immune responses. Swiss Albino mice (laca strain) of both sexes received nicotine dissolved at a dose of 100 µg/ml in 2% sucrose for 24 weeks, by oral gavage, while age- and gender-matched controls received only 2% sucrose for the same period. Nicotine-treated and control mice were sacrificed 6, 16 and 24 weeks post-treatment, and their tissues evaluated for alterations in histology, oxidative stress, TNF-α levels, nitric oxide (NO) and myeloperoxidase (MPO) release, tumor suppressor response and DNA repair response. Statistical significance of results was determined using Students’ t test. The tissues of nicotine treated mice exhibited a large number of multinucleated and binucleated cells, enlarged nuclei and non-uniform distribution of cells, significant increase in expression of TNF-α gene and serum TNF-α, and time-dependent significant increase in lipid peroxidation, protein carbonylation, NO and MPO release when compared to age-and gender-matched controls. The mRNA expression of the tumor suppressor gene p53, its primary regulator Mdm2, and the DNA repair genes Brca2 and Ape1 were significantly elevated, but the corresponding protein levels remained largely unaltered. In conclusion, treatment with nicotine caused oxidative stress and inflammation which can cause widespread cellular damage from the very onset of treatment, without subverting the tumor suppressor and DNA repair responses.Electronic supplementary materialThe online version of this article (10.1007/s12291-020-00903-8) contains supplementary material, which is available to authorized users. 相似文献
7.
Lead poisoning presents a common acquired as well as congenital environmental threat to children’s health today. An unusual case of severe lead poisoning in breast fed male infant is presented here. The objective of the study is to describe a patient who developed clinical lead intoxication with an uncommon source of poisoning. A 6 months old male baby presented with gradual loss of weight, not feeding well and persistent vomiting. Laboratory investigation revealed that he was having anemia (Hb level 5.4 gm/dl), abnormal liver enzymes (including elevated transaminase activity) and high blood lead value (83 μg/dl). RBC morphology showed basophilic stippling with cabot ring, suggestive of a case of lead poisoning. A course of chelation treatment using calcium versenate (EDTACaNa2) was prescribed following which a radical solution for mobilization of lead from his systems was observed. 相似文献
8.
There are a plethora of approaches to construct microtissues as building blocks for the repair and regeneration of larger and complex tissues. Here we focus on various physical and chemical trapping methods for engineering three-dimensional microtissue constructs in microfluidic systems that recapitulate the in vivo tissue microstructures and functions. Advances in these in vitro tissue models have enabled various applications, including drug screening, disease or injury models, and cell-based biosensors. The future would see strides toward the mesoscale control of even finer tissue microstructures and the scaling of various designs for high throughput applications. These tools and knowledge will establish the foundation for precision engineering of complex tissues of the internal organs for biomedical applications. 相似文献
9.
Library data in the form of holdings, expenditures, and transactions continues to be collected. Recently emphasis is being placed on connecting library usage data to student success indicators for purposes of indicating impact. This article describes how one library involved in a large-scale, student success assessment project analyzed usage data linked to unique student IDs prior to connecting data to student academic information. Results revealed a trove of useful information that led to a more robust understanding of how students interacted with library services over the course of a year and are discussed in relation to process improvement. 相似文献
10.
Ipsita Choudhury Mona A. Tilak Arun Kumar Patra 《Indian journal of clinical biochemistry : IJCB》2014,29(1):101-106
Mucopolysaccharidosis are a group of rare metabolic disorders of the lysosomal storage disease family caused by the absence or malfunctioning of lysosomal enzymes responsible for their breakdown. It encompasses disorders in which undegraded or partly degraded glycosaminoglycans accumulate in the lysosomes of many tissues owing to a deficiency of specific lysosomal enzymes. Here we report a case of a 7 years old child displaying the symptoms of Morquio’s disease (Mucopolysaccharidosis type IV). Urine screening tests were performed which gave contrasting results. 相似文献