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1.
K. Pratibha T. Seenappa K. Ranganath 《Indian journal of clinical biochemistry : IJCB》2007,22(2):158-161
Alkaptonuria, a metabolic disorder characterized by a triad of homogentisic aciduria, arthritis and ochronosis is one of the
first conditions in the charter of group of inborn errors of metabolism proposed to have Mendelian recessive inheritance.
It is due to the deficiency of the enzyme homogentisic acid oxidase which catalyzes the conversion of homogentisic acid to
maleylacetoacetic acid in the catabolism of tyrosine. Homogentisic acid thus accumulates in cells and body fluids and its
oxidized polymers bind to collagen, leading to progressive deposition of grey to bluish black pigment resulting in degenerative
changes in cartilage, intervertebral disc and other connective tissues, leading to arthritis which is the only disabling effect
in an affected older individual. However the diagnosis can be made in neonates when blackish stain is noticed in an unwashed
diaper. Alkaptonuria is treated symptomatically, surgical intervention necessitates in advanced stages, treatment with ascorbic
acid (Vitamin C) and dietary restrictions of food containing phenylalanine and tyrosine have proved to be successful in alleviating
the symptoms. 相似文献
2.
K. Pratibha Usha Anand Rajni Agarwal 《Indian journal of clinical biochemistry : IJCB》2004,19(2):128-131
Serum adenosine deaminase (ADA), 5′ nucleotidase (5′NT) and malondialdehyde (MDA) were estimated in patients with acute infective
hepatitis (AIH) along with the routine parameters of liver disease. Present study is done to evaluate these special parameters
in patients with clinical history of AIH and to assess the utility of these parameters as diagnostic/ prognostic indices of
liver function and to correlate special parameters with routine live function tests (LFT). ADA, 5′NT and MDA along with routine
LFT was estimated in 25 patients with AIH and 25 samples from healthy voluntary blood donars served as the control group.
Routine LFT was estimated by standard clinical chemistry procedures on dade behring analyser and ADA, 5′NT and MDA were estimated
by berthlot reaction, fiske and subbarao method and thiobarbituric acid method respectively.
Statistical analysis showed that serum ADA, 5′NT and MDA were significantly higher in patients as compared with the controls.
There was a significant positive correlation between ADA and total bilirubin and MDA and total bilirubin. Hence we can conclude
that these tests would be more sensitive to diagnose the patients with AIH and that the raised bilirubin levels could be looked
upon, as a protective mechanism which the liver has evolved in order to combat oxidative stress. 相似文献
3.
Vandana Dixit Ashok V. Kurup A K Gupta O M Kataria G B K S Prasad 《Indian journal of clinical biochemistry : IJCB》1997,12(1):39-43
Lymphatic filariasis caused byWuchereria bancrofti is a major health problem next only to malaria. A study had been conducted to estimate the prevalence of microfilaraemia in a rural endemic community near Raipur. The incidence of microfilaramia in the community was found to be about 14% when studied by night finger prick method. The incidence appears to be more in males as compared to females. The infection rate in vector population i.e.,Culex quinquefasciatus was recorded at a rate of 10%. No relationship could be drawn between the rates of vector and human filarial infections or between the density of vector population and the rate of vector/human infection(s). Prior health education is essential before taking up control and preventive measures in given endemic zone. 相似文献
4.
Venkateshwari A Sri Manjari K Krishnaveni D Nallari P Vidyasagar A Jyothy A 《Indian journal of clinical biochemistry : IJCB》2011,26(2):136-139
Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine
and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase
9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and
basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic
pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched
healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance
of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared
to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard
to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the
pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may
act as a susceptibility factor for the development of chronic pancreatitis. 相似文献
5.
The cellular manufacturing （CM） has been proved as a well-known manufacturing strategy that helps to improve manufacturing efficiency and productivity by utilizing the philosophy of group technology. Large num- ber of papers has been published in the area of design issues of CM system. Unfortunately, the issues related to acceptability of CM in Indian industries are typically not examined rigorously as technical issues. This paper pre- sents the results of a survey carded out to find the status, enabler and barrier of implementing CM system in Indian industries. 相似文献
6.
Pratibha?GheewalaEmail author 《International journal for the advancement of counseling》2004,26(4):407-413
In a culture where high premium is placed on marriage, a divorced mother faces many challenges. Striving for shelter and economic security is harder due to lack of social acceptance, support and inadequate services. For a counsellor the social realities are as important as the psychological ones.This article is based on the observations and experiences of the author who has been a marriage counsellor at the first Family Court in India. 相似文献
7.
8.
Pratibha Dixit Shally Awasthi Nutan Maurya Sarita Agarwal M. Srinivasan 《Indian journal of clinical biochemistry : IJCB》2015,30(1):35-42
Cystic Fibrosis Trans membrane conductance regulator (CFTR) gene is an asthma susceptibility gene. In the present study we investigated the possible association of CFTR gene mutations in Indian asthmatic children as compared to controls. The study included 250 asthmatics and 250 age and sex matched controls. Case to control ratio for sample size was 1:1. Genotyping was performed for 24 CFTR gene mutations by ARMS-PCR and PCR–RFLP method. Among 24 CFTR gene mutations, heterozygous allele of R553X mutation was found in 4 (1.6 %) asthmatic cases and 2 (0.8 %) controls. Value of FVC and FEV1/FVC ratio were significantly lower in heterozygous individuals (p value <0.05). No significant difference was observed in the genotype and allele frequency of R553X mutation (OR = 1.339, 95 % CI = 0.755–2.374, p value = 0.685). Furthermore, all wild type homozygous alleles were observed in remaining 23 CFTR gene mutations. Our data concludes that R553X mutation was not significantly associated in Indian asthmatic children. 相似文献
9.
HS Batra Ashwini Kumar TK Saha Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2015,30(2):230-233
To establish utility of single enzymatic marker for the diagnosis of acute pancreatitis. This is a cohort study. Tertiary care centre proven cases of acute pancreatitis (n = 50) admitted in surgery ward between December 2011 and May 2013 were included in the study. Serum amylase and lipase were performed along with many analytes. All relevant data including serum lab values and imaging were collected. All 50 patients included in the study had raised serum lipase, 42 patients had both amylase and lipase raised, 8 patients had amylase normal but lipase raised. In smaller hospitals where limited lab and radiological facilities are available, estimation of serum lipase will be a better choice over serum amylase in diagnosis of acute pancreatitis. 相似文献
10.
N. Pattanaik Ajita V Singh R. S. Pandey B. S. Singh Mohan Kumar S. K. Dixit Yamini B. Tripathi 《Indian journal of clinical biochemistry : IJCB》2003,18(2):181-189
Free radicals are implicated in various chronic diseases. There has always been a search for new antioxidants. In this paper
we have investigated Tamra bhasma, a metallic ayurvedic preparation. It is a time-tested medicine in Ayurveda and is in clinical
use for various ailments specifically the free radical mediated diseases. Our results show that Tamra bhasma inhibits lipid
peroxidation (LPO), prevents the rate of aerial oxidation of reduced glutathione (GSH) content and induces the activity of
superoxide dismutase (SOD) in rat liver homogenate in the bi-phasic manner. The drug was orally given for 7, 15 and 30 days
in different doses. Best protective response was found at the dose of 0.5mg/100g body weight in albino rats, although it showed
some histopathological changes at the dose of 20mg/100g body weight. The results suggest that this Ayurvedic preparation is
not merely a source of copper metal, but it is a strong anti-oxidant with no detectable adverse effect in lower doses of therapeutic
range. 相似文献