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Merin Iype Subramanya Upadhya Sharmila Upadhya Gopalakrishna Bhat 《Indian journal of clinical biochemistry : IJCB》2008,23(4):401-403
Experimental model of chronic renal failure in rats have been described by many authors and has also been widely used in various
studies. Many of these methods used highly sophisticated instruments which was difficult in our settings. The resection model
was ideal in our experimental set-up, but this model had the risk of excessive bleeding and hypovolemia. In our study we used
a combination of partial resection and ligation of the renal artery to create two models of stable uremia A and Moderate uremia
B. Severe uremia. Both these models were compared with a sham operated group which served as controls. Following surgical
procedure, the development of uremia was monitored by serial estimation of blood urea and serum creatinine levels that were
measured at regular intervals (bi-weekly). From two weeks onwards the animals in the experimental group showed a significant
elevation in the serum urea levels and a consistent elevation in the serum creatinine levels upto eight weeks when compared
to the animals in the sham operated group. We established a modified method of producing renal failure which can be maintained
for a period of six weeks. This model is simple, reproducible and less complicated that can be used for several studies relating
to renal failure in the field of research. 相似文献
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Sharmila Upadhya Subramanya Upadhya D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(1):46-51
The study was designed to evaluate the significance of tissue polypeptide specific antigen (TPS) in patients with histologically
proven ovarian and colorectal cancer following treatment along with CA125 (in ovarian cancer) and CEA (in colorectal cancer).
Patients were grouped as follows:
In patients with ovarian and colorectal cancer, the mean TPS levels were significantly higher in patients of group II compared
to group I. The percentage of patients above cut-off levels for TPS were 17.4% in group I and 95.5% in group II. Similar results
were observed with the mean levels of CA125. In colorectal cancer patients, the percentage of patients above cut-off levels
for CEA and TPS were 70% and 30% in group I and 100% in group II for both the markers. Our observations indicate that TPS
may be used as a common marker to indicate metastases in patients with ovarian and colorectal cancer. 相似文献
| Group I | : Patients with stable disease |
| Group II | : Patients with metastasis and relapse |
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Sharmila Upadhya Subramanya Upadhya S. Krishna Mohan K. Vanajakshamma Mamatha Kunder Seema Mathias 《Indian journal of clinical biochemistry : IJCB》2004,19(2):80-83
Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels
were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of
radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared
with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels
in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were
no statistically significant differences in all the parameters studied. 相似文献
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Sharmila Upadhya Subramanya Upadhya K. S. Prabhu 《Indian journal of clinical biochemistry : IJCB》2002,17(1):20-24
The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer.
Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All
the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid
levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03).
Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared
to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia,
as serum ceruloplasmin (an acute phase reactant) is also increased in these patients. 相似文献
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Bhaskar S Veena Sharmila Upadhya Satish Kumar Adiga Kumar N Pratap 《Indian journal of clinical biochemistry : IJCB》2008,23(2):186-190
The objective of the study was to estimate the serum concentrations of oxidative stress markers-lipid hydroperoxide (MDA-Malondialdehyde),
lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) — a measure of total antioxidant capacity
in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile
women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum
MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing
to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested
that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant
difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia. 相似文献
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