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Biomicrofluidics is an emerging field at the cross roads of microfluidics and life sciences which requires intensive research efforts in terms of introducing appropriate designs, production techniques, and analysis. The ultimate goal is to deliver innovative and cost-effective microfluidic devices to biotech, biomedical, and pharmaceutical industries. Therefore, creating an in-depth understanding of the transport phenomena of cells and biomolecules becomes vital and concurrently poses significant challenges. The present article outlines the recent advancements in diffusion phenomena of cells and biomolecules by highlighting transport principles from an engineering perspective, cell responses in microfluidic devices with emphases on diffusion- and flow-based microfluidic gradient platforms, macroscopic and microscopic approaches for investigating the diffusion phenomena of biomolecules, microfluidic platforms for the delivery of these molecules, as well as the state of the art in biological applications of mammalian cell responses and diffusion of biomolecules. 相似文献
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Paola Uccelli Özlem Ece Demir-Lira Meredith L. Rowe Susan Levine Susan Goldin-Meadow 《Child development》2019,90(5):1650-1663
This study examines whether children's decontextualized talk—talk about nonpresent events, explanations, or pretend—at 30 months predicts seventh-grade academic language proficiency (age 12). Academic language (AL) refers to the language of school texts. AL proficiency has been identified as an important predictor of adolescent text comprehension. Yet research on precursors to AL proficiency is scarce. Child decontextualized talk is known to be a predictor of early discourse development, but its relation to later language outcomes remains unclear. Forty-two children and their caregivers participated in this study. The proportion of child talk that was decontextualized emerged as a significant predictor of seventh-grade AL proficiency, even after controlling for socioeconomic status, parent decontextualized talk, child total words, child vocabulary, and child syntactic comprehension. 相似文献
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Ingrid Vilà-Giménez Natalie Dowling Ö. Ece Demir-Lira Pilar Prieto Susan Goldin-Meadow 《Child development》2021,92(6):2335-2355
A longitudinal study with 45 children (Hispanic, 13%; non-Hispanic, 87%) investigated whether the early production of non-referential beat and flip gestures, as opposed to referential iconic gestures, in parent–child naturalistic interactions from 14 to 58 months old predicts narrative abilities at age 5. Results revealed that only non-referential beats significantly (p < .01) predicted later narrative productions. The pragmatic functions of the children’s speech that accompany these gestures were also analyzed in a representative sample of 18 parent-child dyads, revealing that beats were typically associated with biased assertions or questions. These findings show that the early use of beats predicts narrative abilities later in development, and suggest that this relation is likely due to the pragmatic–structuring function that beats reflect in early discourse. 相似文献
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Meltem Ö. Gürel 《The International Journal of Art & Design Education》2010,29(2):184-199
This article argues that a design studio can be a dynamic medium to explore the creative potential of the complexity of sustainability from its technological to social ends. The study seeks to determine the impact of an interior design/architecture studio experience that was initiated to teach diverse meanings of sustainability and to engage the participants with refined design applications that used sustainable choices. A teaching scheme that utilised a team of instructors with varying degrees of knowledge and competence in different aspects of the topic, mediated the education of both the students and the instructors themselves. The results were documented through observing the students and, later, a survey of the graduates. The study revealed that this studio experience developed a heightened awareness of sustainability as a multidimensional concept that requires critical thought processes, and greatly influenced the recognition of environmentally responsible design as an imperative in education. The findings also suggested that, ideally, sustainability should be addressed earlier, at lower levels, and needs to be woven into every aspect of a curriculum. 相似文献
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Eren-Şişman Ece N. Çiğdemoğlu Ceyhan Kanlı Uygar Köseoğlu Fitnat 《Science & Education》2020,29(5):1255-1290
Science & Education - The purpose of this study is twofold: first, to delve into professional development (PD) of science teachers’ views about nature of science (NOS) throughout... 相似文献
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Sinem Aslan Nese Alyuz Eda Okur Sinem Emine Mete Ece Oktay Asli Arslan Esme 《Educational technology research and development : ETR & D》2018,66(6):1399-1413
The goal of this research is to investigate the effect of emotion-aware interventions on students’ behavioral and emotional states. To this end, we collected data from 12 students in the 9th grade in a high school in Turkey. The data collection took place in two sessions of an English Course. While the students were reading articles and solving relevant questions, our data collection application running in the background recorded the videos of the individual students through a camera and captured students’ screens in a non-intrusive manner. In total, we had 12.5 h of student data. We employed the human expert labeling process (HELP) (Aslan et al. in Workshop proceedings at international conference on intelligent tutoring systems (ITS), pp 156–165, 2016) to have the data labeled (150 h of data labeling in total). The data collection application was designed in a way that it also collected emotional self-labels (i.e., emotional states as self-reported by students at any time of learning). We leveraged emotional self-label information to suggest various real-time interventions for the students. The results obtained using the final expert labels showed that the percentage of the students’ Satisfied state was significantly higher after interventions. The results also demonstrated that although the interventions were triggered by the emotional states as self-labeled by the students and tailored to improve such states, there was a major positive impact of these interventions on students’ behavioral states. This preliminary study showed that even with a limited set of emotion-aware interventions based on self-labels, students’ states could be impacted positively. Conducting large-scale pilots leveraging more advanced interventions is a future direction for our research. 相似文献
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The objective of this study was to examine the effects of the flipped classroom method on the academic achievement of medical students in the Good Medical Practice Program, collect data on the students’ opinions of this method, and offer solutions to some of the most commonly cited problems in the literature regarding its use. The research design of the study involves a quasi-experimental pretest-posttest design with a control group, and the qualitative research method for answers to follow-up questions. Participants in the study were 38 first-year students from the Faculty of Medicine of Hacettepe University. An academic achievement test and a semi-structured interview form were used as data collection instruments. Findings of the study show that the students taught using the flipped classroom model have higher levels of achievement compared with the students taught using the traditional method. Interviews conducted with the experimental group showed that these students had positive views regarding the flipped classroom method, and it was concluded that solutions offered to deal with the problems, commonly viewed as the disadvantages of the method, were effective. 相似文献
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Libraries and archives are increasingly under pressure to justify the cost of preserving the recorded heritage. This paper addresses the real need to identify and measure the benefits of preservation of the recorded heritage in the UK.
Stated preference techniques are well established in the field of environmental economics, and they are also appropriate for the valuation of cultural heritage. The authors develop and test a methodology to estimate people's preferences for the preservation of the recorded heritage through two stated preference case (pilot) studies.
All library and archive materials supporting the written and documentary heritage of the chosen case studies have been considered. The benefits of preservation are identified as those associated with the use of the recorded heritage (for example, by schools, commercial organisations, academics and other interested parties), the option of using it in the future, and the value placed on its existence by the general public, even if they have no intention of using it.
The main advantage of estimating the benefits of preservation in monetary terms is that these can be compared with the costs of preservation to determine whether any given project or policy is worthwhile, or indeed to choose among competing projects for the allocation of funds. 相似文献
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Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response
Ecem Saygili Ece Yildiz-Ozturk Macauley J. Green Amir M. Ghaemmaghami Ozlem Yesil-Celiktas 《Biomicrofluidics》2021,15(2)
Respiratory viral infections are leading causes of death worldwide. A number of human respiratory viruses circulate in all age groups and adapt to person-to-person transmission. It is vital to understand how these viruses infect the host and how the host responds to prevent infection and onset of disease. Although animal models have been widely used to study disease states, incisive arguments related to poor prediction of patient responses have led to the development of microfluidic organ-on-chip models, which aim to recapitulate organ-level physiology. Over the past decade, human lung chips have been shown to mimic many aspects of the lung function and its complex microenvironment. In this review, we address immunological responses to viral infections and elaborate on human lung airway and alveolus chips reported to model respiratory viral infections and therapeutic interventions. Advances in the field will expedite the development of therapeutics and vaccines for human welfare. 相似文献