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1.
Mamatha T. Shenoy Benedicta D’Souza Lalesh Naik Akshatha Vivian D’Souza Madan Gopal Rajan 《Indian journal of clinical biochemistry : IJCB》2015,30(3):360-362
Tumor lysis syndrome has been observed in patients with malignancies with high cellular burden and high cell turnover, tumor sensitive to therapy, especially after initiating medical treatment. It very rarely occurs spontaneously. The case described here is of 6 months male infant who presented with fever since 1 month and loose stools associated with blood since 15 days. The laboratory investigations showed lactate dehydrogenase (LDH) of 6,192 IU/L and serum uric acid 18.2 mg/dl along with pancytopenia. The infant presented with electrolyte abnormalities and renal failure. 相似文献
2.
Amitabha Ray Anil Kumar Bahadur S. L. Dayalu Naik Bhuvnesh Kumar Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(2):199-202
Endogenous oestrogens are thought to be involved in breast cancer, but few studies could show the direct relationship between
hormones and pathological process of the disease. In the present study, oestradiol was estimated in the serum of pre-and postmenopausal
breast cancer patients along with normal healthy controls and patients with carcinoma of the uterine cervix which is not dependent
on oestrogens. Premenopausal patients with breast cancer showed higher levels of oestradiol as compared to premenopausal control
women as well as cervical cancer patients. Whereas, no statistically significant differences were observed in serum oestradiol
levels amongst postmenopausal groups of breast cancer, cervical cancer and normal women. The result of the study reflects
the association of oestradiol as well as its difference in the pathological events of pre and postmenopausal breast cancer. 相似文献
3.
Bhanu P. Singh Banani Banerjee Puspanita Naik Jordan N. Fink Viswanath P. Kurup 《Indian journal of clinical biochemistry : IJCB》2006,21(2):20-27
The ubiquitous fungus Aspergillus fumigatus causes allergic rhinitis, asthma, sinusitis and allergic bronchopulmonary aspergillosis.
A number of major allergens from A. fumigatus are purified, but their structure-function role in the pathogenesis of disease
is not known. Such information is essential for devising alternative therapy of fungal allergic diseases. In the present study,
N-terminal and C-terminal deletion mutants ofAsp f 3 were constructed and their immunopathological responses studied in a mice model of allergy. Three mutants viz,Asp f 3 (aa 33–168), (aa 1–142), and (aa 23–142) were made by deleting certain amino acids from epitopic regions of full lengthAsp f 3, a major allergen of A. furnigatus. TheAsp f 3 and three mutated proteins were expressed in pET vector. The C-terminal deletion mutantAsp f 3 (aa 1–142) induced elevated IFN-γ but low levels of IL-4 by spleen cells. This mutant also showed significant downregulation
of peripheral blood eosinophils and lung inflammation in immunized mice. The N-terminal deletion mutantAsp f 3 (aa 33–168) also exhibited an immuno-suppressive effect in terms of IgE production and induction of Th2 cytokine. The results
indicate thatrAsp f 3 and its deletion mutants induced distinct immune-inflammatory responses in mice on challenge with these proteins. The non-IgE
binding deletion mutants ofAsp f 3 (aa 1–142 and aa 33–168) could deviate Th2 immune response with a concomitant reduction in airway inflammation and infiltration
of inflammatory cells. 相似文献
4.
India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life
span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis
in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1)
to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women
and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy
(alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically
diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited
as control. Mean bone mineral density T score and Z score was significantly decreased (P < 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of
BMD—T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels
were significantly increased (P < 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P < 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor
of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of
osteoporosis and for monitoring responses to antiresorptive therapy. 相似文献
5.
Meera S. Ghadge Purva P. Naik Bijaynath P. Tiwari Ruprekha M. Hegde Tanaji J. Matale 《Indian journal of clinical biochemistry : IJCB》2012,27(1):97-99
Breast cancer is one of the most frequent malignancies in the world. Available staging procedures to detect breast cancer
are bone scan, chest X-ray, liver ultrasonography, computerized tomography, estimation of tumor markers like carbohydrate
antigen (CA15-3) and carcino embryonic antigen. These procedures are expensive and may not be required in all cases. Out of
70 patients studied, 55 had normal CA15-3 and 15 had elevated levels of Ca15-3. Eight (14.5%) of the 55 patients with normal
CA15-3 had abnormal bone scan. Fifteen patients had CA15-3 levels above the normal range and among these 9 (60%) had abnormal
bone scan. While prime facie it would appear that a high level of CA15-3 correlate with abnormal bone scan, it is also true
that the numbers are small at present and conclusions about the validity of CA15-3 as marker of bone metastasis may be premature. 相似文献
6.
Chad D. Ellett Karen S. Loup Nitin S. Naik Sheila W. Chauvin Joseph G. Claudet 《Journal of Personnel Evaluation in Education》1994,8(4):349-375
Wheeling Jesuit College 相似文献
7.
C. I. Jhala U. V. Shah T. K. Shah B. K. Naik J. D. Dafda 《Indian journal of clinical biochemistry : IJCB》1998,13(1):1-7
Fasting samples of 1329 apparently healthy vegetarian Gujarati population were tested for total cholesterol, triglycerides
and three major fractions of lipoproteins, i.e. high density lipoproteins, low density lipoproteins and very low density lipoproteins.
All the values showed marked increase with the age. Except for serum triglycerides, values differ in males and females in
the age group of above 45 years. Compared to Northern Indian population low density lipoprotein and high density lipoprotein
values were higher, but values of triglycerides and very low density lipoproteins were lower. There is no significant difference
in total cholesterol values. Compared to Southern Indian population low density lipoprotein and very low density lipoprotein
values were higher but values of triglycerides, total cholesterol and high density lipoprotein were lower. All serum lipid
values were significantly lower than the Westem population. The range of values for both the sexes is presented for different
age groups. 相似文献
8.
The relationship between bowling action classification and three-dimensional lower trunk motion in fast bowlers in cricket 总被引：1，自引：1，他引：0
Lower back injuries, specifically lumbar stress fractures, account for the most lost playing time in professional cricket. The aims of this study were to quantify the proportion of lower trunk motion used during the delivery stride of fast bowling and to examine the relationship between the current fast bowling action classification system and potentially injurious kinematics of the lower trunk. Three-dimensional kinematic data were collected from 50 male professional fast bowlers during a standing active range of motion trial and three fast bowling trials. A high percentage of the fast bowlers used a mixed bowling action attributable to having shoulder counter-rotation greater than 30 degrees. The greatest proportion of lower trunk extension (26%), contralateral side-flexion (129%), and ipsilateral rotation (79%) was used during the front foot contact phase of the fast bowling delivery stride. There was no significant difference in the proportions of available lower trunk extension, contralateral side-flexion, and ipsilateral rotation range of motion used during fast bowling by mixed and non-mixed action bowlers. Motion of the lower trunk, particularly side-flexion, during front foot contact, in addition to variables previously known to be related to back injury (e.g. shoulder counter-rotation), should be examined in future cross-sectional and prospective studies examining the fast bowling action and low back injury. 相似文献
9.
In the recent years, two significant changes have taken place in an effort to address rural poor: Businesses have started recognizing potential of rural markets and governments have started using telecenters for providing G2C services to rural citizens. In India, the national and sub-national governments have supported businesses to establish telecenters in rural areas to provide information technology enabled services. However, the focus so far has been mostly on B2C services and viability of telecenters is being questioned. We argue that sustainability of these centers can be enhanced considerably if government services are embedded. Also, designing these telecenters with embedded G2C services would significantly improve effectiveness of their delivery and strengthen government information network, to foster inclusive growth. 相似文献
10.