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Despite the myriad of soft lithography based micropatterning methods available to researchers, it is still challenging to define small features (10–100 μm) that are spaced far apart (1–10 mm). In this report, we describe a combined microfluidic-microstencil patterning method that can produce multifunctional substrates of small features, O(10 μm), with a large pitch, O(1 mm). In that, we fabricate microstencils using an UV curable polyurethane (Norland Optical Adhesive 81) with dense arrays of 10–100 μm holes. Overlaying arrays of microfluidic channels over these microstencils allow for the control of the spacing between features and the ability to pattern multiple substrates. We show that this method is capable of patterning soluble proteins, fibrillar insoluble collagen, liposomes, cells, and nanoparticles. We demonstrate the utility of the method by measuring platelet adhesion under flow to three adhesive proteins (insoluble fibrillar collagen, laminin, and reconstituted acid solubilized collagen fibers) in a single assay. 相似文献
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Gurpreet K Rana Doreen R Bradley Stanley J Hamstra Paula T Ross Robert E Schumacher John G Frohna Hilary M Haftel Monica L Lypson 《Journal of the Medical Library Association》2011,99(1):77-81
Objective:
The objective of this study was to validate an assessment instrument for MEDLINE search strategies at an academic medical center.Method:
Two approaches were used to investigate if the search assessment tool could capture performance differences in search strategy construction. First, data from an evaluation of MEDLINE searches from a pediatric resident''s longitudinal assessment were investigated. Second, a cross-section of search strategies from residents in one incoming class was compared with strategies of residents graduating a year later. MEDLINE search strategies formulated by faculty who had been identified as having search expertise were used as a gold standard comparison. Participants were presented with a clinical scenario and asked to identify the search question and conduct a MEDLINE search. Two librarians rated the blinded search strategies.Results:
Search strategy scores were significantly higher for residents who received training than the comparison group with no training. There was no significant difference in search strategy scores between senior residents who received training and faculty experts.Conclusion:
The results provide evidence for the validity of the instrument to evaluate MEDLINE search strategies. This assessment tool can measure improvements in information-seeking skills and provide data to fulfill Accreditation Council for Graduate Medical Education competencies.Highlights
- The University of Michigan MEDLINE Search Assessment tool can be used to assess search skills in residency education.
- Five elements were identified as critical elements in the development of an effective MEDLINE search strategy: inclusion of all search concepts, appropriate use of Medical Subject Headings, appropriate use of search limits, successful combination of all concepts, and search efficiency.
Implications
- This validated assessment tool can serve as an effective means to measure improvements in residents'' information-seeking skills and provide data to fulfill Accreditation Council for Graduate Medical Education competencies.
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Minds Under Siege: Cognitive Signatures of Poverty and Trauma in Refugee and Non-Refugee Adolescents
Alexandra Chen Catherine Panter-Brick Kristin Hadfield Rana Dajani Amar Hamoudi Margaret Sheridan 《Child development》2019,90(6):1856-1865
The impacts of war and displacement on executive function (EF)—what we might call the cognitive signatures of minds under siege—are little known. We surveyed a gender-balanced sample of 12- to 18-year-old Syrian refugees (n = 240) and Jordanian non-refugees (n = 210) living in Jordan. We examined the relative contributions of poverty, trauma exposure, posttraumatic stress, and insecurity to variance in inhibitory control and working memory. We observed associations between poverty and WM, suggesting that, even in populations exposed to substantial violence and fear, poverty is a specific pathway to WM deficit. We did not, however, find associations between EFs and exposures to trauma. Careful distinction between childhood adversities may illuminate which neurocognitive pathways matter for measures of cognitive function. 相似文献
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Resilience in Context: A Brief and Culturally Grounded Measure for Syrian Refugee and Jordanian Host‐Community Adolescents 
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下载免费PDF全文 Catherine Panter‐Brick Kristin Hadfield Rana Dajani Mark Eggerman Alastair Ager Michael Ungar 《Child development》2018,89(5):1803-1820
Validated measures are needed for assessing resilience in conflict settings. An Arabic version of the Child and Youth Resilience Measure (CYRM) was developed and tested in Jordan. Following qualitative work, surveys were implemented with male/female, refugee/nonrefugee samples (N = 603, 11–18 years). Confirmatory factor analyses tested three‐factor structures for 28‐ and 12‐item CYRMs and measurement equivalence across groups. CYRM‐12 showed measurement reliability and face, content, construct (comparative fit index = .92–.98), and convergent validity. Gender‐differentiated item loadings reflected resource access and social responsibilities. Resilience scores were inversely associated with mental health symptoms, and for Syrian refugees were unrelated to lifetime trauma exposure. In assessing individual, family, and community‐level dimensions of resilience, the CYRM is a useful measure for research and practice with refugee and host‐community youth. 相似文献
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Rana Duncan-Daston Maude Hunter-Sloan Elise Fullmer 《Ethics and Information Technology》2013,15(1):35-43
The ethical implications of the explosion of social media outlets for social work education are explored in this paper. Given that social work education has a dual focus, both of educating students and of socializing practitioners into the profession, the issue of the blurring between what is social and what is professional gains particular salience for both educators and students. Recommendations for educators to ethically address the need to maintain a consistent professional presence online and to avoid potentially harmful dual relationships with students are presented. These recommendations include: abstain from using social media or use only a static professional profile; use only university protected sites to promote collaboration with students in the classroom including all students to avoid any appearance of impropriety; use social media with the utmost discretion mindful of all the risks by creating a very select circle of friends, separating one’s personal site from one’s professional site; develop policies which include not friending any individual student or any current student and inform students about the policies. 相似文献
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Evolving developments in psychodynamic theory have strengthened it as an evidence-based approach and have made it concordant with social work’s strengths-based, multicultural perspective. An elective focused on teaching fundamental concepts of psychodynamic psychotherapy was developed for graduate social work students based on Kolb’s theory of experiential learning, applied to Summers and Barber’s pragmatic model of psychodynamic psychotherapy. Data were collected based on students’ experienced self-efficacy with specific competencies in psychodynamic psychotherapy in the first, sixth, and last class. Outcomes were positive, and the data were used to make specific suggestions to strengthen course outcomes. 相似文献
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Second law of thermodynamics can be apparently violated in systems whose dynamics depend on information acquired by measurement. However, when one considers measurement and erasure together with the system, it saves the second law. We consider the simple example of an information machine, where information is used as a resource to increase the machine’s performance. The system is connected to two baths, a work source, and a moving tape which is used as an information reservoir. The performance of the device is autonomous. The system acts as an engine, erasure or refrigerator. Even combination of any two is possible. All these possibilities are allowed by the generalized second law. 相似文献
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