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The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections. Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however, role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma.  相似文献   
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International Journal for Educational and Vocational Guidance - The present study discusses a pilot intervention for youth in a predominantly Latinx rural community in the U.S. The intervention...  相似文献   
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Distance education has grown rapidly in the United States in recent years. Both private‐ and public‐sector organizations have embraced the practice of reaching their clients, employees, and students at a distance via new technologies afforded them by the telecommunication and computer nexus. Distance education is grounded on technology, and its practice would be difficult, if not impossible, without it. However, reducing the idea to its technological foundations, and losing sight of its social science base has led to a conceptual confusion in the field. This article will illustrate the growth of distance education in the United States, describe the social science paradigm of distance education, demonstrate the empirical evidence of this paradigm, and analyze its ramifications for the field in general, as well as for students, educational organizations, and instructors.  相似文献   
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In this paper, we examine the role of reflection in teacher preparation, specifically within a mentoring relationship between cooperating and preservice teacher. We report findings from a case analysis of this pair who engaged in problem-posing dialogue within pre- and post-conferences around practice over one year of their work together in an elementary-level classroom. The context is an innovative programme in which cooperating teachers pursue their Master’s degree while undergraduates (preservice teachers) complete their elementary education degrees. Our analysis of talk about teaching during six coaching cycles as well as supporting documents illustrates how Jane’s mentoring supported reflective practices and disrupted a notion of a field experience as simply a place to ‘practice’ pedagogical knowledge with corrective feedback. Additionally, we explore the tensions in this approach to mentoring. This case study has implications for teacher educators who seek to bolster teacher preparation through the support of mentoring relationships.  相似文献   
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The study described in this article takes the view that distance education programs are dynamic systems with multiple constituencies. Literature on distance education programs as complex systems and on the critical constituency approach to program evaluation was used to guide the development of a questionnaire designed to assess the components of a distance education program. Instrument development was conducted in four phases using both quantitative and qualitative methods. The data from this study suggest that there are four major components of effectiveness in distance education programs: instruction, management, telecommuting, and support. Within each of these components there are from two to five subcomponents, 14 components in all, which can be used to assess distance education programs. The assessment scale which was developed measures these four components and their subcomponents.  相似文献   
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This paper provides a foundational framework to bring into conversation indigenous world views in reimagining universities. Highlighting a specific indigenous world view, the university is presented as a site for critical conversation and transformative praxis. We discuss the workplace experiences of indigenous staff in a university and infer from these how management practices related to indigenous staff could be enhanced. Building on our study of Māori academic and administrative staff in a New Zealand university, an indigenous typology and a Wero or challenge matrix is offered, which locates different positions and actions that universities adhere to or seek to emulate. The paper argues for universities to reimagine their policies and practices by drawing from the complex richness of indigenous world views.  相似文献   
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