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Kadam DP Suryakar AN Ankush RD Kadam CY Deshpande KH 《Indian journal of clinical biochemistry : IJCB》2010,25(4):388-392
Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various
exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently,
it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system
may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity
was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects)
and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant
enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects.
As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with
decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis
suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and
decreased antioxidant potential in psoriasis. 相似文献
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Jerry Joseph Emanuel Dickson M. B. Kadam P. K. Joseph 《Indian journal of clinical biochemistry : IJCB》1991,6(1):27-29
Rats were fasted for 8 hours and then fed 3 ml of 25% (v/v) ethanol per 100g body weight and subsequently sacrificed 18 hours
later. The levels of triacylglycerols and total cholesterol were significantly raised in serum and liver of alcohol fed rats.
However, when rats were fed on aqucous extract of onions (300 mg per 100g body weight) with 25% ethanol, no rise in serum
and liver lipids was observed. Alcohol fed to the fats with or without onion extract had no effect on serum, AST, ALT and
alkaline phosphatase levels. The increase in serum urea in ethanol-fed rats was not altered in rats fed a mixture of alcohol
and onion extracts. Values of liver MDA was lower in rats fed ethanol with or without onion extract compared to controls.
Onion extract seemed to show a hypolipidemic effect in alcohol fed rats. 相似文献
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Suchitra Surve Shahina Begum Beena Joshi M. Ikram Khatkhatay Seema Kadam Sanjay Chauhan 《Indian journal of clinical biochemistry : IJCB》2021,36(2):167
Despite ample sunshine, 50–90% Indian children have Vitamin D deficiency (VDD). This enigma of widespread VDD needs exploration especially among under-fives as physiological variations in Vitamin D Binding Protein (VDBP) levels could be potential confounders in the interpretation of total 25-hydroxyvitamin D [25(OH)D]. However, there is scarce information about relevance of VDBP levels in under-five age group. We therefore, explored association of VDBP levels among 1–5 year old children with VDD. Serum levels of 25(OH)D, VDBP, calcium, parathyroid hormone (PTH) and alkaline phosphatase were estimated in 210 apparently healthy children in the age group of 1–5 years. VDD was defined as serum 25(OH)D levels < 20 ng/ml as per the IOM classification. VDBP levels were classified as low if levels were < 168 μg/ml as per the kit. The prevalence of VDD was 79.5% (n = 167) and VDBP levels were low in 48.6% (n = 102) of children. 25(OH)D levels correlated positively with VDBP (r = 0.298, p = 0.0001). A significant number of children (52.7%) with VDD had low VDBP (p = 0.015). and despite adequate sun exposure, 43% of children showed VDD and 56.6% had low VDPB levels. The low VDBP levels largely explain low 25OHD levels without necessarily implying VDD. It may add a new dimension for better understanding of widespread VDD among under-five children. It thus, points towards the need for redefining cut offs and complete evaluation of vitamin D status among under-fives including VDBP. 相似文献
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