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Abstract

Thirty-six male rats were used; divided into 6 groups (n = 6): saline; creatine (Cr); eccentric exercise (EE) plus saline 24 h (saline + 24 h); eccentric exercise plus Cr 24 h (Cr + 24 h); eccentric exercise plus saline 48 h (saline + 48 h); and eccentric exercise plus Cr 48 h (Cr + 48h). Cr supplementation was administered as a solution of 300 mg · kg body weight?1 · day?1 in 1 mL water, for two weeks, before the eccentric exercise. The animals were submitted to one downhill run session at 1.0 km · h?1 until exhaustion. Twenty-four and forty-eight hours after the exercise, the animals were killed, and the quadriceps were removed. Creatine kinase levels, superoxide production, thiobarbituric acid reactive substances (TBARS) level, carbonyl content, total thiol content, superoxide dismutase, catalase, glutathione peroxidase, interleukin-1b (IL-1β), nuclear factor kappa B (NF-kb), and tumour necrosis factor (TNF) were analysed. Cr supplementation neither decreases Cr kinase, superoxide production, lipoperoxidation, carbonylation, total thiol, IL-1β, NF-kb, or TNF nor alters the enzyme activity of superoxide dismutase, catalase, and glutathione peroxides in relation to the saline group, respectively (P < 0.05). There are positive correlations between Cr kinase and TBARS and TNF-α 48 hours after eccentric exercise. The present study suggests that Cr supplementation does not decrease oxidative stress and inflammation after eccentric contraction.  相似文献   
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This paper describes a study of “Word Score”, a serious game designed to extend the vocabulary of pupils in upper primary school in the Netherlands. Word Score was used in one school community as part of the national project “Educational Time Extension” (ETE). In ETE class time is extended beyond normal school hours with the aim of improving the learning outcomes of under-performing pupils. The study showed that the use of Word Score can be effective during ETE. The vocabulary of the pupils who played the game outside the regular class time significantly increased. The experiences of both pupils and teachers were very positive. The pupils liked playing Word Score and the teachers were very enthusiastic about the game and the pupils’ results.  相似文献   
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The predicaments which the industrial age of the twentieth century has left with us are briefly discussed, namely nature in peril, man in crisis and nation at risk. It is argued that these predicaments are brought upon us by the predominantly analytic thinking of the past century represented in the various forms of dichotomize such as mind and matter, man and nature, East and West, etc. It is, then, asserted that the twenty-first century should an age of synthesis, which the education for synthesis are specifically highlighted and discussed: the philosophy of the whole person, the building of sequentially broader self-identities, and strategies of conflict solution. Editor’s note Address presented at the First International Conference Editor’s note Address presented at the First International Conference Editor’s note Address presented at the First International Conference Editor’s note Address presented at the First International Conference Editor’s note Address presented at the First International Conference  相似文献   
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