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Hajar Eftekhari Maryam Pilehchian Langroudi Ali Banihashemi Mandana Azizi Reza Youssefi Kamangar Haleh Akhavan-Niaki 《Indian journal of clinical biochemistry : IJCB》2018,33(2):231-234
α-Thalassemia (α-thal) is considered as the most common inherited hemoglobin disorder worldwide. The present study describes the first observation of a combination of rare α-chain variants, and β-globin gene cluster deletion. A 21-year-old woman with thalassemia trait, marked microcytosis, mild anemia, and normal range of Hb F was referred to Amirkola genetic center in the North of Iran for routine molecular test of thalassemia in the context of carrier detection and prevention of thalassemia major birth. Nucleotide sequencing revealed a novel compound heterozygosity status for two non-deletional mutations on HBA2, Hb O Indonesia (α116(GH4)Glu → Lys), and Hb Matsue–Oki (α75 (EF4) Asp → Asn), together with heterozygosity for the sicilian (δβ)0-thal mutation. This finding highlights the necessity of deep molecular investigation of thalassemia in regions where thalassemia is abundant, and present highly heterogeneous population. 相似文献
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Sadegh Fattahi Mohammad Karimi Alivije Farhang Babamahmoodi Masomeh Bayani Mahmoud Sadeghi Haddad Zavareh Mohsen Asouri Maryam Lotfi Galia Amirbozorgi Haleh Akhavan-Niaki 《Indian journal of clinical biochemistry : IJCB》2018,33(4):467-472
Hepatitis B virus (HBV) infection is a worldwide health concern which is associated with significant morbidity and mortality. Both viral and host factors have a significant effect on infection, replication and pathogenesis of HBV. The aim of this study was to investigate the effect of CYP2E1 and CYP1A1 genetic variants on susceptibility to HBV. 143 individuals including 54 chronic HBV patients and 89 healthy controls were enrolled in the genotyping procedure. rs2031920 and rs3813867 at CYP2E1 as well as rs4646421 and rs2198843 at CYP1A1 loci were studied in all subjects using PCR–RFLP (restriction fragment length polymorphism) analysis. Both variants at CYP2E1 locus were monomorphic in all studied subjects. Genotype frequency of rs4646421 was significantly different between chronic HBV patients and healthy blood donors (P = 0.04, OR 4.31; 95% CI 1.04–17.7). Furthermore, individuals carrying at least one C allele (CC or CT genotypes) for rs4646421 seemed to have a decrease risk of hepatitis in comparison with TT genotype (P = 0.039). Our results showed a relationship between rs4646421 TT genotype (rare genotype) and the risk for developing chronic HBV infection (four times higher). Further studies are needed to examine the role of CYP1A1 polymorphism in susceptibility to chronic HBV infection. 相似文献
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International Trends in Health Science Librarianship Part 18: The Middle East (Iran,Qatar and Turkey) 
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下载免费PDF全文 Kimia Zeraatkar Haleh Ayatollahi Tracy Havlin Karen Neves Mesra Şendir 《Health information and libraries journal》2016,33(2):156-160
This is the 18th in a series of articles exploring international trends in health science librarianship in the 21st century. The focus of the present issue is the Middle East (Iran, Qatar and Turkey). The next feature column will investigate trends in the Balkan States JM 相似文献
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Children generally favor individuals in their own group over others, but it is unclear which dimensions of the out-group affect this bias. This issue was investigated among 7- to 8-year-old and 11- to 12-year-old Iranian children (N = 71). Participants evaluated in-group members and three different out-groups: Iranian children from another school, Arab children, and children from the United States. Children’s evaluations closely aligned with the perceived social status of the groups, with Americans viewed as positively as in-group members and Arabs viewed negatively. These patterns were evident on measures of affiliation, trust, and loyalty. These findings, which provide some of the first insights into the social cognition of Iranian children, point to the role of social status in the formation of intergroup attitudes. 相似文献
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Jonathan K. Fernand Haleh Amanieh David J. Cox Nicole R. Dorey 《Learning & behavior》2018,46(4):472-478
The reverse-reward contingency (RRC) task involves presenting subjects with a choice between one plate containing a large amount of food and a second plate containing a small amount of food. Subjects are then required to select the smaller of the two options in order to receive the larger-magnitude reward. The RRC task is a commonly used paradigm for assessing complex cognition, such as inhibitory control, in subjects. To date, the RRC task has not been tested with pet dogs as subjects, and it may provide insights to their ability to perceive quantities of differing magnitudes. Nine dogs were tested in an RRC task involving three conditions. In Condition 1, plates of food were presented, and the dogs were allowed to consume their choice. In Condition 2, plates with different-sized symbols resembling the quantities of food in Condition 1 were presented, and dogs received food quantities of the same size as their choice (e.g., a larger-magnitude reward for selecting the plate with the larger shape). In Condition 3, the same plates were presented, but dogs received a reverse-sized quantity of food, relative to their choice (e.g., a smaller-magnitude reward for selecting the plate with the larger shape). A novel addition here to the traditional RRC task was the inclusion of a third, empty (control) plate that was present throughout all conditions, and no programmed consequences were provided when that plate was selected. Our results were consistent with the previous RRC literature: All dogs developed and maintained a preference for the larger stimulus option across conditions. The use of symbolic representations did not ameliorate performance on the RRC task. Applied implications are discussed. 相似文献
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Mohammad Allahbakhsh Haleh Amintoosi Behshid Behkamal Amin Beheshti Elisa Bertino 《Journal of Informetrics》2021,15(2):101127
In collaborative content generation (CCG), such as publishing scientific articles, a group of contributors collaboratively generates artifacts available through a venue. The main concern in such systems is the quality. A remarkable range of research considers quality metrics partially when dealing with the quality of artifacts, contributors, and venues. However, such approaches have several drawbacks. One of the most notable ones is that they are not comprehensive in terms of the metrics to evaluate all entities, including artifacts, contributors, and venues. Also, they are vulnerable to potential attacks.In this paper, we propose a novel iterative definition in which the quality of artifacts, collaborators, and venues are defined interconnectedly. In our framework, the quality of an artifact is defined based on the quality of its contributors, venue, references, and citations. The quality of a contributor is defined based on the quality of his artifacts, collaborators, and the venues. Quality of a venue is defined based on both quality of artifacts and contributors. We propose a data model, formulations, and an algorithm for the proposed approach. We also compare the robustness of our approach against malicious manipulations with two well-known related approaches. The comparison results show the superiority of our method over other related approaches. 相似文献
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