Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Should Gender Differences be Considered When Assessing Student Satisfaction in the Online Learning Environment for Millennials?          下载免费PDF全文

Heather Lea Harvey  Sanjai Parahoo  Mohammad Santally 《Higher Education Quarterly》2017,71(2):141-158

The majority of today's students in online higher education are millennials and have grown up using technology. Therefore, there is a need to determine if their expectations from online learning are different from previous contextual studies and whether or not these vary across gender. This study used a mixed method approach, using focus groups, followed by online surveys of 834 undergraduate students from the University of Mauritius enrolled in an online course. Using factor analysis and structural equation modelling, the study found no significant differences based on gender for millennials, but identified three significant antecedents of student satisfaction for both males and females: university reputation; physical facilities; and instructor empathy.  相似文献   

Reaching Out to Veteran Teachers     

Masami Matoba  Yoshiaki Shibata  Mohammad Reza Sarkar Arani 《TechTrends》2007,51(3):21-29

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How online career counseling changes career development: A life design paradigm     

Nooshin Pordelan  Ahmad Sadeghi  Mohammad Reza Abedi  Marjan Kaedi 《Education and Information Technologies》2018,23(6):2655-2672

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Exploring and evaluating differentiated assessment practices of in-service teachers for components of differentiation     

Amrita Kaur  Mohammad Noman  Rosna Awang-Hashim 《Teaching Education》2019,30(2):160-176

Classroom assessment is central to effective teaching and learning, making assessment literacy a core component for teacher education. The present study explores self-reported, differentiated assessment practices of Malaysian in-service teachers. The practices were evaluated using an analytic framework that was developed based upon the existing literature on components of differentiation. Data were collected from 32 in-service teachers using open-ended survey questionnaires. Twelve of the teachers also participated in in-depth interviews. Documents provided by the teachers were also analyzed. Data from the open-ended survey were analyzed using NVivo11 to develop codes for the analytic framework. The findings offer insights into teachers’ knowledge, application, and interpretation of differentiated assessment practices. The discussion explores teachers’ explanations of their own practices and, further, recommends ways to improve knowledge and application of differentiated assessment. The implications of the findings are discussed for assessment literacy-related professional development for teachers, school management and policies to facilitate implementation of differentiated assessment.  相似文献   

Understanding divergent domestication traits from the whole-genome sequencing of swamp- and river-buffalo populations     

Xier Luo  Yu Zhou  Bing Zhang  Yi Zhang  Xiaobo Wang  Tong Feng  Zhipeng Li  Kuiqing Cui  Zhiqiang Wang  Chan Luo  Hui Li  Yanfei Deng  Fenghua Lu  Jianlin Han  Yongwang Miao  Huaming Mao  Xiaoyan Yi  Cheng Ai  Shigang Wu  Alun Li  Zhichao Wu  Zijun Zhuo  Do Da Giang  Bikash Mitra  Mohammad Farhad Vahidi  Shahid Mansoor  Sahar Ahmed Al-Bayatti  Eka Meutia Sari  Neena Amatya Gorkhali  Sigit Prastowo  Laiba Shafique  Guoyou Ye  Qian Qian  Baoshan Chen  Deshun Shi  Jue Ruan  Qingyou Liu 《国家科学评论(英文版)》2020,7(3):686

Domesticated buffaloes have been integral to rice-paddy agro-ecosystems for millennia, yet relatively little is known about the buffalo genomics. Here, we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals (132 swamp buffaloes and 98 river buffaloes) sampled from across Asia and Europe. Beyond the many actionable insights that our study revealed about the domestication, basic physiology and breeding of buffalo, we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior, digestion metabolism, strengths and milk production.  相似文献   

Provenance study of ancient Iranian luster pottery using PIXE multivariate statistical analysis     

Davoud Agha-Aligol  Parvin Oliaiy  Mohammad Mohsenian  Mohammad Lamehi-Rachti  Farah Shokouhi   《Journal of Cultural Heritage》2009,10(4):487-492

Although luster potteries are frequently excavated at archeological sites in Iran, a thorough scientific study of their provenance has not yet been performed. In this work, 43 pieces of Iranian luster pottery (bowl, dish and tile) excavated from Rayy, Kashan, Maragheh, Alamoot, Takht-i-Sulayman and Jiroft were analyzed in order to investigate their origin. The luster shards which belong to Seljuks and Il-Khanids dynasties (12th–13th centuries) were analyzed using proton induced X-ray emission (PIXE) technique. To classify the fragments according to their location and origin, principal component analysis (PCA) and hierarchical cluster analysis (HCA) were applied to the chemical compositions of the body of the shards. We were able to classify the samples into three distinct groups using PIXE.  相似文献   

Investigation of the Effects of Inulin and β-Glucan on the Physical and Sensory Properties of Low-Fat Beef Burgers Containing Vegetable Oils: Optimisation of the Formulation Using D-Optimal Mixture Design     

Roya Afshari  Hedayat Hosseini  Ramin Khaksar  Mohammad Amin Mohammadifar  Zohre Amiri  Rozita Komeili  Amin Mousavi Khaneghah 《Food Technology and Biotechnology》2015,53(4):436-445

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Determination of Biological Variance and Validation of a Fluorometric Assay for Measurement of α-l-Iduronidase Activity in Dried Blood Spots Samples: The First Experience in Iran     

Mohammad Abdi  Mohammad Said Hakhamaneshi  Mohammad Reza Alaei  Namam-Ali Azadi  Rahim Vakili  Daniel Zamanfar  Mohammad Taghikhani  Shohreh Khatami 《Indian journal of clinical biochemistry : IJCB》2015,30(3):318-322

Methods for assaying lysosomal diseases in dried blood samples are very useful today due to its several advantages related to the stability of samples, its transportation, handled and analysis, and its potential use for newborn screening compared to traditional methods in leucocytes samples. For this reason, it is important to validate these assays before being used in routine laboratory. Because of different in biological markers based on ethnicity, we aimed this study to validation a DBS-based fluorometric assay for measurement of α-l-Iduronidase activity for diagnosis of MPS I patients in Iran. DBS samples were collected from 15 MPS I patients and 60 healthy age matched subjects. Diagnostic value, biological variance and α-l-Iduronidase activity were determined. DBS α-l-Iduronidase activity was significantly higher in male subjects than in female group. Using a cut-off level of 1.08 µmol/spot 20 h, sensitivity and specificity were 100 and 98 %. The linearity of test was proved and we showed that within-run and between run precision were 5.6 and 14.66 %. Measurement of α-l-Iduronidase activity in DBS samples is an accurate test for diagnosis of MPS I and because of its rapid shipping and simplicity to keeping, DBS-based enzyme activity could be considered as a useful diagnostic tool in this disease.  相似文献   

The Effect of Group Logotherapy on Meaning in Life and Depression Levels of Iranian Students     

Somaye Robatmili  Faramarz Sohrabi  Mohammad Ali Shahrak  Siavash Talepasand  Mostafa Nokani  Mohaddese Hasani 《International journal for the advancement of counseling》2015,37(1):54-62

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