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Oxygen and glucose supply is one of the important factors for the growth and viability of the cells in cultivation of tissues, e.g., spheroid, multilayered cells, and three-dimensional tissue construct. In this study, we used finite element methods to simulate the flow profile as well as oxygen and glucose supply to the multilayered cells in a microwell array chip for static and perfusion cultures. The simulation results indicated that oxygen supply is more crucial than glucose supply in both static and perfusion cultures, and that the oxygen supply through the wall of the perfusion culture chip is important in perfusion cultures. Glucose concentrations decline with time in static cultures, whereas they can be maintained at a constant level over time in perfusion cultures. The simulation of perfusion cultures indicated that the important parameters for glucose supply are the flow rate of the perfusion medium and the length of the cell culture chamber. In a perfusion culture chip made of oxygen-permeable materials, e.g., polydimethylsiloxane, oxygen is hardly supplied via the perfusion medium, but mainly supplied through the walls of the perfusion culture chip. The simulation of perfusion cultures indicated that the important parameters for oxygen supply are the thickness of the flow channel and the oxygen permeability of the walls of the channel, i.e., the type of material and the thickness of the wall. 相似文献
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Qinglei Wang Yanan Qian Ruihua Song Zhicheng Dou Fan Zhang Tetsuya Sakai Qinghua Zheng 《Information Retrieval》2013,16(4):484-503
Web search queries are often ambiguous or faceted, and the task of identifying the major underlying senses and facets of queries has received much attention in recent years. We refer to this task as query subtopic mining. In this paper, we propose to use surrounding text of query terms in top retrieved documents to mine subtopics and rank them. We first extract text fragments containing query terms from different parts of documents. Then we group similar text fragments into clusters and generate a readable subtopic for each cluster. Based on the cluster and the language model trained from a query log, we calculate three features and combine them into a relevance score for each subtopic. Subtopics are finally ranked by balancing relevance and novelty. Our evaluation experiments with the NTCIR-9 INTENT Chinese Subtopic Mining test collection show that our method significantly outperforms a query log based method proposed by Radlinski et al. (2010) and a search result clustering based method proposed by Zeng et al. (2004) in terms of precision, I-rec, D-nDCG and D#-nDCG, the official evaluation metrics used at the NTCIR-9 INTENT task. Moreover, our generated subtopics are significantly more readable than those generated by the search result clustering method. 相似文献
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Takako Yuki Keiko Mizuno Keiichi Ogawa Sakai Mihoko 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2013,59(1):47-66
Many girls are not sent to school in Yemen, despite basic education being free as well as compulsory for all children aged 6–15. Aiming to improve girls’ enrolment by increasing parental and community involvement, the Japan International Cooperation Agency (JICA) offered a technical cooperation project in June 2005 called Broadening Regional Initiative for Developing Girls’ Education (BRIDGE). Phase 1 of this project ran for three and a half years, piloting a participatory school management model supported by school grants in six districts of the Taiz Governorate in the Southwest of Yemen. To find out how successful this approach has been in a traditional society, the authors of this paper analysed the gender parity index (GPI) of the project’s pilot schools. Based on data collected at three points in time (in the initial and final years of the project, and two years after the project’s end), their findings suggest that interventions in school management which strongly emphasise girls’ education can be effective in improving gender parity rather quickly, regardless of the schools’ initial conditions. However, the authors also observe that the pilot schools’ post-project performance in terms of gender parity is mixed. While the local government allocated budgets for school grants to all pilot schools even after the project’s end, training and monitoring activities were cut back. The authors further observe that the variation in performance appears to be significantly correlated with school leaders’ initial perceptions of gender equality and with the number of female teachers employed. These findings point to the importance of providing schools with continuous long-term guidance and of monitoring those which implement school improvement programmes. 相似文献
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James V. Devine Luther C. Jones Janice W. Neville Dilys J. Sakai 《Learning & behavior》1977,5(1):57-62
Two experiments were performed to determine the effect of sample duration (0.1, 2, and 4 sec), delay interval (.03, 4, 8, 16, and 32 sec), and type of stimulus (color and shape) on the matching performance of rhesus monkeys. In Experiment 1, the 15 possible delay-duration combinations were randomly presented in blocks of 15 trials. In Experiment 2, each duration was held constant and the five delays randomly presented. Then each delay interval was held constant with the three durations randomly varied. Matching performance increased as sample duration increased (ps < .01 and .005), while length of delay did not significantly affect performance. The type of stimuli paired in the matching test significantly affected performance (ps < .05 and .10) with the shape/shape choices leading to the poorest performance. Stimulus discriminability and amount of training with brief sample durations were implicated as significant determinants of matching performance. 相似文献
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In rapid interceptive actions such as hitting a baseball, cricket ball or tennis ball, ball speed varies between trials, and players have to compensate the time lag by controlling the moment of movement onset and movement duration. Previous studies have found that these two variables can flexibly co-vary and are robustly influenced by target speed (i.e. velocity-coupling effect: faster movement for faster target). However, some studies reported an interpersonal variability in the timing control strategy and the relationship between the strategy and temporal accuracy in rapid interception is unclear. We used a baseball-simulated rapid interceptive task to assess this issue. Under relatively easy time constraints, there was a large interpersonal variability, and participants were distinctively divided into two groups: those who mainly modulated their movement duration and those who mainly controlled their movement onset. When the time constraint became severe, the second strategy shifted to the first strategy in most of the second group participants. In the both cases, being able to mainly control movement onset resulted in higher temporal accuracy. These results suggest that minimising the velocity-coupling effect is an important factor to achieve high temporal accuracy in rapid interception. 相似文献
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This meta-analytic study estimated the correlations among metacognition, intelligence, and academic performance. Metacognition is higher order cognition and one of the most significant predictors of academic performance. The purpose of this study was to examine the degree to which metacognition predicted academic performance when controlling for intelligence. The analysis of 149 samples from 118 articles revealed that, overall, metacognition weakly correlated with both academic performance and intelligence, and that these relationships were moderated by the type of measurement of metacognition. Furthermore, it was found that metacognition predicted academic performance when controlling for intelligence. Our findings indicate the importance of metacognition in educational practice and provide guidance for assessing metacognition in future research. 相似文献
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Tetsuya Kobayashi 《Higher Education》1980,9(6):681-692
This article discusses the role of the university in Japan's technological and industrial development. In the first part the historical development of the university in terms of technological and industrial development is treated in four sections, as follows:
- 1868–1886 - higher education and Westernization;
- 1886–1914 - Japan's industrial revolution and the university;
- 1914–1945 - industrial development between the wars and the expansion of the university;
- 1945-the present - the new university system and post-war industrial progress.
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Counseling development models have many of the same purposes and address many of the same phenomena as the cognitive science models of expertise. But these two model types have been developed independently and each has drawn only minimally from the other. The purpose of this article is to point out some of the similarities and differences between the model types. 相似文献