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1.
A. Supriya Simon D. Dinesh Roy V. Jayapal T. Vijayakumar 《Indian journal of clinical biochemistry : IJCB》2010,25(2):164-168
Cardiometabolic syndrome is one of the major public health issues of this century which describes a cluster of clinical characteristics.
Seventy two patients with coronary artery disease (CAD) and cardiometabolic syndrome and forty healthy age and sex matched
normal controls were selected for this study. Detailed clinical epidemiological and anthropometric characteristics were noted.
Lipid profile and Cytokinesis-block micronuclei (CBMN) assay using cytochalasin B were carried out in all the subjects. Serum
total cholesterol, triglyceride and LDL-cholesterol was significantly higher and HDL cholesterol was significantly lower in
patients compared to their normal counter-parts (P<0.05). CBMN frequency of the patients was significantly higher at all ages
compared to their normal counter parts (P<0.05). Various risk factors like diabetes, hypertension, dyslipidemia, abdominal
obesity, smoking and alcoholism were found influenced the CBMN frequency; but the changes were not significant. From this
study it can be concluded that DNA damage was found to be higher in patients with cardiometabolic syndrome which may be attributed
to the generation of free radicals associated with alcohol consumption, tobacco use, dyslipidemia and glucose intolerance
and the accumulation of free radicals with increase in age. 相似文献
2.
Most of the Indian University Libraries are accessible not only to the academic and research communities but also to the general public. In this paper, an attempt is made to describe the effects of ICT developments on Indian University Libraries, how much they have been able to catch up with more developed institutions and what the future agenda for connecting knowledge and communities will be. This paper gives an idea about ICT developments in India, ICT applications in Indian University Libraries, and the role of INFLIBNET and future programs. 相似文献
3.
C. S. Parameswari B. Vijayageetha R. Vijayakumar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):131-136
The oxidative modification of lipoprotein especially low density lipoprotein (LDL) plays a key role in the initiation and
progression of atherosclerosis. Serum apolipoproteinB (apoB) level is found to be an important marker for atherosclerosis.
The present paper focuses on the measurement of serum apoB levels and the effect of Vitamin E, Vitamin C and reduced glutathione
on the copper ion induced oxidation of LDL + VLDL (VLDL-Very Low Density Lipoprotein) lipoprotein fraction isolated from the
serum of chronic renal failure (CRF) and renal transplanted patients. The level of apoB is significantly higher in the serum
of transplanted patients when compared to CRF patients and normal subjects. The level of TBARS formed in oxidized LDL + VLDL
lipoprotein fraction of CRF and renal transplanted patients are significantly increased than normal even in the presence of
antioxidants but the level of TBARS produced, with antioxidants is comparatively lesser than that produced by oxidized lipoprotein
fraction without antioxidants. It may be concluded than that produced by oxidized lipoprotein fraction without antioxidants.
It may be concluded that oxidation of LDL can be prevented at an earlier stage by Vitamin E supplementation. The supplementation
with Glutathione serves as the best method of preventing the lipoprotein oxidation among the renal diseased patients. 相似文献
4.
5.
J.K Vijayakumar Manju Vijayakumar 《International Information and Library Review》2013,45(2-4):375-382
Most of the Indian University Libraries are accessible not only to the academic and research communities but also to the general public. In this paper, an attempt is made to describe the effects of ICT developments on Indian University Libraries, how much they have been able to catch up with more developed institutions and what the future agenda for connecting knowledge and communities will be. This paper gives an idea about ICT developments in India, ICT applications in Indian University Libraries, and the role of INFLIBNET and future programs. 相似文献
6.
Functional ovarian hyperandrogenism (FOH) is a form of polycystic ovary syndrome (PCOS) characterized by elevated circulating levels of androgens derived from the ovary. Insulin resistance (IR) is the most common etiological factor in women with FOH. IR causes the generation of increased oxidative stress (OS) and diminished antioxidant status. OS is directly correlated with both IR and testosterone levels, which consequently contribute to endocrine and biochemical alterations in FOH women. In the current study, elevations in total testosterone, free testosterone and luteinizing hormone (LH) levels accompanied by a decrease in follicle stimulating hormone (FSH) level leading to higher LH:FSH ratio were the prominent endocrine changes observed in women with FOH. A significant increase in fasting blood levels of glucose and insulin, as well as an elevated IR were also seen in FOH women, as compared to their age matched controls. Women with FOH have higher pro-oxidant and lower anti-oxidant levels in blood than their age matched controls. In FOH women, elevations in LH:FSH ratio and OS are correlated more with hyperandrogenemia than with IR. Of the androgens, free rather than total testosterone has better positive correlations with elevated LH:FSH ratio and OS, and hence, the former is a better predictive marker for the development of biochemical PCOS in women with FOH. 相似文献
7.
D. Vijayakumar K. Suresh S. Manoharan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):52-55
The present study has investigated the levels of lipids, lipoprotein cholesterol (HDL and LDL cholesterol), thiobarbituric
acid reactive substances (TBARS) and vitamin E in plasma and erythrocyte membranes of twenty two clinically diagnosed adult
rheumatoid arthritis patients and an equal number of age matched healthy subjects. The levels of lipids and lipoprotein cholesterol
were markedly reduced in patients with rheumatoid arthritis as compared to healthy subjects. The altered lipid pattern may
be related to decreased lipoprotein cholesterol, fatty acids and impairment in antioxidant defence mechanism. 相似文献
8.
Saroja Kumar Panda Vijayakumar Mallappa 《Journal of Interlibrary Loan, Document Delivery & Electronic Reserve》2013,23(3-5):133-147
Resource-sharing normally follows a network of libraries with decent rules and regulations and provides a common platform for libraries and library staffs to come together, communicate, and extend help to enhance access to information and fulfill the unexpected demands of users. This article studies the use of interlibrary loan and document delivery service at the Information and Library Network Centre under the UGC-Infonet Digital Library Consortium program. Universities that come under the purview of the University Grants Commission (UGC), Government of India, become members of UGC-Infonet Digital Library Consortium. The article discusses the recent literature on resource-sharing through interlibrary loan and document delivery service practice in the Indian context. This article suggests improvement of J-Gate Plus discovery and resource-sharing service to enhance access to information resources and for better document delivery. 相似文献
9.
Supriya Simon A Dinesh Roy D Jayapal V Vijayakumar T 《Indian journal of clinical biochemistry : IJCB》2011,26(1):50-56
Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus. Even
though many ethological factors have been attributed for the pathogenesis of this disease no attempts were made to correlate
DNA damage as a causative factor. Hence the present study was undertaken to asses the extent of somatic DNA damages by cytokinesis-block
micronuclei assay (CBMN). An attempt is also being made to correlate the habits and/or risk factors and socioeconomic status
with CAN. The CBMN frequency of 46 patients suffering from autonomic neuropathy was compared with that of 25 healthy age and
sex matched controls. All the subjects were suffering from type 2 diabetes for at least 8 years and have varying degrees of
coronary artery diseases. The mean CBMN frequency of the patients was statistically higher than that of the healthy control
subjects (P < 0.05). The CBMN frequency was found to be significantly altered in CAN patients who where physical inactivity and smoking.
A significant correlation could also be observed between CAN and smoking, diabetes mellitus, hypertension, dyslipidemia, abdominal
obesity, and physical activity. 相似文献
10.
Srinivas Narasimhachar Chakravarthy Satish Ramanathan Smitha Menon Vijayakumar Valappil Mathivanan Durairaj Jayarani Arokia 《Indian journal of clinical biochemistry : IJCB》2018,33(1):113-116
Paraproteinemia is characterised by clonal proliferation of plasma cells. A common laboratory finding in paraproteinemia being a monoclonal peak in serum protein electrophoresis (M band). But there are factors which produce a peak similar to M spike in serum protein electrophoresis and these factors are known as pseudoparaproteins. This case report discusses a rare cause of pseudo M spike in a known case of autoimmune hemolytic anaemia due to administration of drug-Rituximab, a monoclonal antibody by itself. 相似文献